The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons.

abstract：:Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervic...

journal_title：Neuroscience research

authors： Soinila S,Lakshmanan J,Lahtinen T

更新日期：1988-12-01 00:00:00

abstract：:A mixture of peptidase inhibitors increased the magnitude of the saphenous nerve-evoked slow depolarization of a lumbar ventral root and prolonged the similarly evoked inhibition of monosynaptic reflex (MSR) in the isolated spinal cord of the newborn rat in the presence of naloxone. The saphenous nerve-evoked MSR inhi...

journal_title：Neuroscience research

authors： Yanagisawa M,Yoshioka K,Kurihara T,Saito K,Seno N,Suzuki H,Hosoki R,Otsuka M

更新日期：1992-12-01 00:00:00

abstract：:In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...

journal_title：Neuroscience research

authors： Yoshida M,Satoh T,Nakamura KC,Kaneko T,Hata Y

更新日期：2009-05-01 00:00:00

abstract：:Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former ...

journal_title：Neuroscience research

authors： Tomimoto H

更新日期：2011-11-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between the increase in local cerebral blood flow during neuronal activation (evoked LCBF) and the baseline flow level. We measured the hemodynamics in alpha-chloralose-anesthetized rats using laser-Doppler flowmetry during somatosensory stimulation under the...

journal_title：Neuroscience research

authors： Matsuura T,Fujita H,Kashikura K,Kanno I

更新日期：2000-12-01 00:00:00

abstract：:To elucidate the molecular mechanisms that regulate the maturation of action potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in thi...

journal_title：Neuroscience research

authors： Wakazono Y,Kurahashi T,Nakahira K,Nagata I,Takayama C,Inoue Y,Kaneko A,Ikenaka K

更新日期：1997-12-01 00:00:00

abstract：:In rat hippocampal CA1 neurons recorded intracellularly from tissue slices, a rapid depolarization occurred approximately 5 min after application of ischemia-simulating medium. In extracellular recordings obtained from CA1 region, a rapid negative-going DC potential (rapid DC potential) was recorded, corresponding to ...

journal_title：Neuroscience research

authors： Uchikado H,Tanaka E,Yamamoto S,Isagai T,Shigemori M,Higashi H

更新日期：2000-02-01 00:00:00

abstract：:We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

journal_title：Neuroscience research

authors： Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

更新日期：2009-01-01 00:00:00

abstract：:Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...

journal_title：Neuroscience research

authors： Muramatsu R,Yamashita T

更新日期：2014-01-01 00:00:00

abstract：:The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

journal_title：Neuroscience research

authors： Oohira A,Katoh-Semba R,Watanabe E,Matsui F

更新日期：1994-09-01 00:00:00

abstract：:In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of anaesthetised rats, whilst simultaneously recording activity of sensory afferents on the adventitial surface of femoral arteries and veins. Bradykinin (0.9 nmol...

journal_title：Neuroscience research

authors： Smith PJ,McQueen DS

更新日期：2004-11-01 00:00:00

abstract：:Spinal reflex arcs mediated by low threshold afferents between the brachioradialis (BR) and flexor carpi radialis (FCR) were studied in eleven healthy human subjects using a post-stimulus time-histogram method. Electrical conditioning stimuli (ES) to the radial nerve branch innervating BR with the intensity below the ...

journal_title：Neuroscience research

authors： Kobayashi S,Hayashi M,Shinozaki K,Nito M,Hashizume W,Miyasaka T,Shindo M,Naito A

更新日期：2016-09-01 00:00:00

abstract：:Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...

journal_title：Neuroscience research

authors： Amino T,Uchihara T,Tsunekawa H,Takahata K,Shimazu S,Mizusawa H,Orimo S

更新日期：2008-03-01 00:00:00

abstract：:l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in schizophrenia or related psychiatric conditions. Here we repo...

journal_title：Neuroscience research

authors： Ozeki Y,Pickard BS,Kano S,Malloy MP,Zeledon M,Sun DQ,Fujii K,Wakui K,Shirayama Y,Fukushima Y,Kunugi H,Hashimoto K,Muir WJ,Blackwood DH,Sawa A

更新日期：2011-02-01 00:00:00

abstract：:In order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (LH) concentrations were measured in female rats after making lesions in this nucleus (DRL) and/or treatment with 5-hydroxytryptamine (5-HT) receptor...

journal_title：Neuroscience research

authors： Maekawa F,Tsukahara S,Tsukamura H,Maeda KI,Yamanouchi K

更新日期：1999-12-30 00:00:00

abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...

journal_title：Neuroscience research

authors： Yamaguchi Y

更新日期：2018-04-01 00:00:00

abstract：:Excitatory synaptic connections between rat hippocampal neurons were established in tissue culture. The electrophysiological and pharmacological properties of these synapses were studied with the use of the tight-seal whole-cell recording technique. The excitatory postsynaptic current (EPSC) in a dissociated CA1 neuro...

journal_title：Neuroscience research

authors： Ozawa S,Iino M,Abe M

更新日期：1991-10-01 00:00:00

abstract：:Acute exposure to kainic acid (KA) induces neurochemical changes in dopaminergic systems in the brain and the aim of the present study was to investigate the acute toxicity of KA upon dopamine D2 receptors. Adult rats were injected intraperitoneally with either saline or 16 mg/kg KA. Brains were removed after 4 h. Mem...

journal_title：Neuroscience research

authors： Ridd MJ,Kitchen I,Fosbraey P

更新日期：1998-03-01 00:00:00

abstract：:TDP-43 pathology in motor neurons is a hallmark of ALS. In addition, the reduced expression of an RNA editing enzyme, adenosine deaminase acting on RNA 2 (ADAR2), increases the expression of GluA2 with an unedited Q/R site in the motor neurons of patients with sporadic ALS. As the occurrence of these two disease-speci...

journal_title：Neuroscience research

authors： Yamashita T,Hideyama T,Teramoto S,Kwak S

更新日期：2012-06-01 00:00:00

abstract：:This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...

journal_title：Neuroscience research

authors： Day AS,Wen CY,Shieh JY,Sun WZ,Lue JH

更新日期：2001-08-01 00:00:00

abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...

journal_title：Neuroscience research

authors： Koike T,Kan S,Misaki M,Miyauchi S

更新日期：2011-04-01 00:00:00

abstract：:Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the β- and γ-secretases generates Aβ peptides; however, the alternate cleavage of APP by the α- and γ-secretases decreases Aβ production. We previously reported th...

journal_title：Neuroscience research

authors： Yoshida H,Meng P,Matsumiya T,Tanji K,Hayakari R,Xing F,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Imaizumi T

更新日期：2014-02-01 00:00:00

abstract：:Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...

journal_title：Neuroscience research

authors： Lévesque M,Wallman MJ,Parent R,Sík A,Parent A

更新日期：2007-03-01 00:00:00

abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...

journal_title：Neuroscience research

authors： Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres A

更新日期：2008-07-01 00:00:00

abstract：:The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...

journal_title：Neuroscience research

authors： Sun S,Ohta A,Kuhara A,Nishikawa Y,Kage-Nakadai E

更新日期：2020-01-01 00:00:00

abstract：:A single-pulse TMS to the human motor cortex (M1) influences reaction time (RT). We may summarize from previous studies where different groups of subjects participated in various types of RT tasks that TMS above motor threshold (MT) delays RT, whereas TMS below MT shortens RT and that these RT changes depends on TMS t...

journal_title：Neuroscience research

authors： Hashimoto T,Inaba D,Matsumura M,Naito E

更新日期：2004-12-01 00:00:00

abstract：:Concurrent eye and hand movements toward a common visual target require different motor programs based on identical visual input. We used event-related brain potentials (ERP) to determine if and when the processing of the visual target differs for the two motor systems. The N2, an index for target evaluation, was more...

journal_title：Neuroscience research

authors： Wehrspaun CC,Pfabigan DM,Sailer U

更新日期：2013-09-01 00:00:00

abstract：:The responses of slice-cultured Purkinje cells to trans-DL-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD) were examined by intracellular recording techniques and fura-2 microfluorometry. Bath-application of t-ACPD (100 microM, 30 s), a selective agonist of metabotropic glutamate receptors (mGluRs), to Purkinje cel...

journal_title：Neuroscience research

authors： Vranesic I,Staub C,Knöpfel T

更新日期：1993-03-01 00:00:00

abstract：:Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...

journal_title：Neuroscience research

authors： Ito Y,Honda A,Igarashi M

更新日期：2018-03-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) is a major component of the cell wall of gram negative bacteria contributing to the pathogenesis of bacterial infection, in particular in those diseases affecting central nervous system and reproductive tissues. The present work is an attempt to study the regulation of steroidogenic ...

journal_title：Neuroscience research

authors： Sadasivam M,Ramatchandirin B,Ayyanar A,Prahalathan C

更新日期：2014-06-01 00:00:00