Abstract：
:The NRG1 growth factor and ERBB4 receptor have been identified as leading schizophrenia risk genes. Although NRG1 and ERBB4 have been shown to modulate neuronal functions involved in schizophrenia, including both GABAergic and glutamatergic synapses, the exact molecular mechanisms remain poorly understood. Here we investigated ERBB4 intracellular domain, 4ICD, transactivator function in rat hippocampal cultures by inhibiting γ-secretase mediated ERBB4 regulated intramembrane proteolysis (RIP). NRG1 stimulation resulted in a dramatic increase in the number of hippocampal cells displaying nuclear 4ICD which was abolished in cultures pretreated with the γ-secretase inhibitor compound E (CE). To identify NRG1-4ICD transactivated genes we compared global gene expression profiles of hippocampal cultures stimulated with NRG1 in the absence or presence of CE. In concordance with the contribution of NRG1-ERBB4 signaling to dendritic spine maturation and schizophrenia, global gene expression analysis followed by Ingenuity Pathway Analysis of the dataset identified NRG1-4ICD regulated genes significantly represented in semaphorin signaling and actin cytoskeletal plasticity and multiple genes with confirmed roles in dendritic spine morphogenesis. Using the power of global gene expression analysis our data provides a proof-of-concept supporting a role for non-canonical NRG1-4ICD signaling in the regulation of gene expression contributing to normal and schizophrenic neuronal function.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Allison JG,Das PM,Ma J,Inglis FM,Jones FEdoi
10.1016/j.neures.2011.02.009subject
Has Abstractpub_date
2011-06-01 00:00:00pages
155-63issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(11)00051-4journal_volume
70pub_type
杂志文章abstract：:To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...
journal_title：Neuroscience research
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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更新日期：2002-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2012.02.012
更新日期：2012-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.05.005
更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.neures.2018.10.004
更新日期：2019-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.05.001
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1991-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.05.014
更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.03.009
更新日期：2004-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:To study the differences between peripheral nerve (PN) and embryonic homologous CNS structures as a conduit for CNS axons, spinal cord segments in neonatal rats were removed at the mid-thoracic level and PN or embryonic spinal cord (ESC) segments were grafted into the vacancy. Neural connections across the graft were ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00042-x
更新日期：1998-07-01 00:00:00
