Abstract：
:Contradictory data on behavioral changes in MPTP-treated C57BL/6 mice have been reported, even though the toxin-treated mice have been widely used for non-clinical studies as an in vivo model of Parkinson's disease (PD). We found that the duration of immobility in the tail suspension test (TST) was significantly increased in MPTP-treated C57BL/6 mice as compared with control mice without a significant change in the locomotor activity (LA). Dopamine (DA) contents and protein levels of tyrosine hydroxylase and dopamine transporter in the striatum were profoundly decreased in the toxin-treated mice. These behavioral and neurobiochemical changes were almost completely inhibited by a pretreatment with deprenyl, a monoamine oxidase-B inhibitor. The stimulation of dopaminergic neurotransmission induced by L-dopa or a dopamine D2 receptor agonist ameliorated the increase in immobility time. Threshold level of striatal DA that produced the increase in immobility time in MPTP-treated mice was estimated to be between 11 and 27% of control level. We concluded that the increase in immobility time in the TST was induced by the nigrostriatal dopaminergic degeneration and was thought to be a consequence of motor dysfunction in this mouse model of PD.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Mori A,Ohashi S,Nakai M,Moriizumi T,Mitsumoto Ydoi
10.1016/j.neures.2004.11.008subject
Has Abstractpub_date
2005-03-01 00:00:00pages
265-74issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(04)00301-3journal_volume
51pub_type
杂志文章abstract：:Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.07.002
更新日期：2006-10-01 00:00:00
abstract：:Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.11.006
更新日期：2013-01-01 00:00:00
abstract：:Although sleep is strongly implicated in memory consolidation, the molecular basis for the role of sleep in memory is not known. It has been established that the consolidation of hippocampus-dependent memory depends on the activation of the Erk1,2 MAP kinase (MAPK) pathway which activates de novo CRE-mediated transcri...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.04.011
更新日期：2017-05-01 00:00:00
abstract：:To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N). SEP was recorde...
journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
doi：10.1016/s0168-0102(03)00129-9
更新日期：2003-08-01 00:00:00
abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.07.003
更新日期：2020-06-01 00:00:00
abstract：:We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.08.008
更新日期：2003-12-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a recently identified member of the secretin/vasoactive intestinal polypeptide (VIP) family. There are at least two types of receptor for PACAP: type I (PACAPR), which specifically binds PACAP; and type II (VIP/PACAPR), which binds both PACAP and VIP. The l...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00065-5
更新日期：1997-08-01 00:00:00
abstract：:The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90020-9
更新日期：1986-05-01 00:00:00
abstract：:A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.05.001
更新日期：2011-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.12.001
更新日期：2019-11-01 00:00:00
abstract：:Aging is a natural biological process associated with several neurological disorders along with the biochemical changes in brain. Aim of the present investigation is to study the effect of carnosine (0.5-2.5μg/kg/day, i.t. for 21 consecutive days) on aging-induced changes in brain regional (cerebral cortex, hippocampu...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.09.009
更新日期：2015-03-01 00:00:00
abstract：UNLABELLED:Angiotensin II receptors (Ang II), classified into AT1 and AT2 subtypes, are located in different regions of the central nervous system, including the cardiovascular control centers in the medulla oblongata. We previously reported the role of Ang II AT1 receptors within the medulla on cardiovascular response...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.008
更新日期：2009-08-01 00:00:00
abstract：:Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00213-3
更新日期：2001-02-01 00:00:00
abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00255-3
更新日期：2001-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90057-w
更新日期：1993-12-01 00:00:00
abstract：:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...
journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
doi：10.1016/s0168-0102(02)00007-x
更新日期：2002-04-01 00:00:00
abstract：:Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.06.006
更新日期：2016-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.09.001
更新日期：2018-07-01 00:00:00
abstract：:This study was designed to evaluate the anticonvulsant effects of imperatorin (a furanocoumarin isolated from fruits of Angelica archangelica) in the mouse maximal electroshock seizure threshold model. The threshold for electroconvulsions in mice was determined at several times: 15, 30, 60 and 120 min after i.p. admin...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.05.004
更新日期：2007-09-01 00:00:00
abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.10.001
更新日期：2005-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:Efferent neurons to the cochlea in the guinea pig were observed in the superior olivary complex and ventral lateral lemniscal nuclei after injection of WGA-HRP into the cochlea via the round window. Of HRP-labeled nerve cells found in the brainstem, about 60% and 10% were located in the ipsilateral lateral superior ol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90003-x
更新日期：1988-10-01 00:00:00
abstract：:Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for major mental illnesses, including bipolar disorder and schizophrenia. Although the roles of DISC1 in nervous system development and functions are increasingly recognized, pathophysiological mechanisms underlying a range of neuropsychiatric symptoms caus...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.05.014
更新日期：2011-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.08.004
更新日期：2014-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.07.2031
更新日期：2010-11-01 00:00:00
abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.007
更新日期：2018-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2011.06.004
更新日期：2011-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00159-0
更新日期：2000-10-01 00:00:00
abstract：:In the vertebrate nervous system, glutamate (Glu) receptors are generally known to cause depolarizing responses. We report here a novel type of Glu response in Purkinje neurons of mouse cerebellar slices, namely glutamate-induced hyperpolarization (GH). This response is not due to activation of inhibitory interneurons...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90047-g
更新日期：1992-12-01 00:00:00
abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
