Abstract:
:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Watanabe A,Kato N,Kato Tdoi
10.1016/s0168-0102(02)00007-xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
279-85issue
4eissn
0168-0102issn
1872-8111pii
S016801020200007Xjournal_volume
42pub_type
临床试验,杂志文章abstract::Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.04.003
更新日期:2007-07-01 00:00:00
abstract::According to the amyloid hypothesis for the pathogenesis of Alzheimer's disease (AD), amyloid beta peptide (Abeta) directly affects neurons, leading to neurodegeneration and tau phosphorylation, followed by the production of paired helical filaments (PHF) in neurofibrillary tangles (NFT). To analyze the relationship b...
journal_title:Neuroscience research
pub_type: 杂志文章
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journal_title:Neuroscience research
pub_type: 杂志文章,评审
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journal_title:Neuroscience research
pub_type: 杂志文章
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00119-3
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journal_title:Neuroscience research
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journal_title:Neuroscience research
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1988-04-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.09.001
更新日期:2008-12-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.04.010
更新日期:2012-07-01 00:00:00
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journal_title:Neuroscience research
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pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.07.003
更新日期:2020-06-01 00:00:00
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更新日期:1994-05-01 00:00:00
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journal_title:Neuroscience research
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journal_title:Neuroscience research
pub_type: 杂志文章
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.06.1467
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journal_title:Neuroscience research
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journal_title:Neuroscience research
pub_type: 临床试验,杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
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