Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.


:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.


Neurosci Res


Neuroscience research


Watanabe A,Kato N,Kato T




Has Abstract


2002-04-01 00:00:00














  • Formation and disruption of functional domains in myelinated CNS axons.

    abstract::Communication in the central nervous system (CNS) occurs through initiation and propagation of action potentials at excitable domains along axons. Action potentials generated at the axon initial segment (AIS) are regenerated at nodes of Ranvier through the process of saltatory conduction. Proper formation and maintena...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Griggs RB,Yermakov LM,Susuki K

    更新日期:2017-03-01 00:00:00

  • Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.

    abstract::The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Abdin AA,Sarhan NI

    更新日期:2011-12-01 00:00:00

  • Substance P immunoreactivity in the vagal nerve of mice.

    abstract::After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Funakoshi K,Kusakabe T,Kadota T,Goris RC,Kishida R

    更新日期:1989-12-01 00:00:00

  • Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.

    abstract::Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

    更新日期:2016-11-01 00:00:00

  • Postsynaptic density visualized by whole mount electron microscopy.

    abstract::Detergent-unextractable structures of synaptic plasma membrane of rat cerebrum were observed by whole mount electron microscopy. The globular structures were identified as postsynaptic densities (PSDs) from several criteria and appeared to consist of folded strings, to which a number of other molecules might be attach...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Suzuki T,Tanaka R

    更新日期:1986-02-01 00:00:00

  • Different perceptual sensitivities for Chernoff's face between children and adults.

    abstract::The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

    更新日期:2008-02-01 00:00:00

  • Super-oxide anion production and antioxidant enzymatic activities associated with the executive functions in peripheral blood mononuclear cells of healthy adult samples.

    abstract::Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Bl...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Pesce M,Rizzuto A,La Fratta I,Tatangelo R,Campagna G,Iannasso M,Ferrone A,Franceschelli S,Speranza L,Patruno A,De Lutiis MA,Felaco M,Grilli A

    更新日期:2016-05-01 00:00:00

  • The effect of acute kainic acid treatment on dopamine D2 receptors in rat brain.

    abstract::Acute exposure to kainic acid (KA) induces neurochemical changes in dopaminergic systems in the brain and the aim of the present study was to investigate the acute toxicity of KA upon dopamine D2 receptors. Adult rats were injected intraperitoneally with either saline or 16 mg/kg KA. Brains were removed after 4 h. Mem...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ridd MJ,Kitchen I,Fosbraey P

    更新日期:1998-03-01 00:00:00

  • Synaptic structure and axon collaterals of type B neurons in bullfrog sympathetic ganglia: intracellular horseradish peroxidase (HRP)-labeling study.

    abstract::Type B neurons of the bullfrog sympathetic ganglia were examined to confirm the existence of axon collaterals and the distribution of synaptic contacts using the intracellular horseradish peroxidase (HRP) labeling method. The mean diameter of the perikarya was 60.8 (+/- 11.5 standard deviation; n = 36) X 43.8 (+/- 11....

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Murata Y,Chiba T,Kumamoto E,Kuba K

    更新日期:1989-10-01 00:00:00

  • Two different effects of transcranial magnetic stimulation to the human motor cortex during the pre-movement period.

    abstract::A single-pulse TMS to the human motor cortex (M1) influences reaction time (RT). We may summarize from previous studies where different groups of subjects participated in various types of RT tasks that TMS above motor threshold (MT) delays RT, whereas TMS below MT shortens RT and that these RT changes depends on TMS t...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hashimoto T,Inaba D,Matsumura M,Naito E

    更新日期:2004-12-01 00:00:00

  • Appearance of a fast inactivating voltage-dependent K+ currents in developing cerebellar granule cells in vitro.

    abstract::To elucidate the molecular mechanisms that regulate the maturation of action potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in thi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Wakazono Y,Kurahashi T,Nakahira K,Nagata I,Takayama C,Inoue Y,Kaneko A,Ikenaka K

    更新日期:1997-12-01 00:00:00

  • Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra.

    abstract::Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lévesque M,Wallman MJ,Parent R,Sík A,Parent A

    更新日期:2007-03-01 00:00:00

  • Inhibition of gustatory plasticity due to acute nicotine exposure in the nematode Caenorhabditis elegans.

    abstract::The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the respo...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Matsuura T,Miura H,Nishino A

    更新日期:2013-11-01 00:00:00

  • Architecture of binocular disparity processing in monkey inferior temporal cortex.

    abstract::Neurons in the inferior temporal (IT) cortex respond not only to the shape, color or texture of objects, but to the horizontal positional disparity of visual features in the right and left retinal images. IT neurons with similar shape selectivity cluster in columns. In this study, we examined how IT neurons are spatia...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Yoshiyama K,Uka T,Tanaka H,Fujita I

    更新日期:2004-02-01 00:00:00

  • daf-16/FOXO isoform b in AIY neurons is involved in low preference for Bifidobacterium infantis in Caenorhabditis elegans.

    abstract::The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sun S,Ohta A,Kuhara A,Nishikawa Y,Kage-Nakadai E

    更新日期:2020-01-01 00:00:00

  • Inhibitory influence via 5-HT3 receptors on the induction of LTP in mossy fiber-CA3 system of guinea-pig hippocampal slices.

    abstract::The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Maeda T,Kaneko S,Satoh M

    更新日期:1994-01-01 00:00:00

  • Unilateral lesions of mesostriatal dopaminergic pathway alters the withdrawal response of the rat hindpaw to mechanical stimulation.

    abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

    更新日期:2005-05-01 00:00:00

  • Navigation ability dependent neural activation in the human brain: an fMRI study.

    abstract::Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using funct...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ohnishi T,Matsuda H,Hirakata M,Ugawa Y

    更新日期:2006-08-01 00:00:00

  • Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.

    abstract::Neuropathic pain is a very complex chronic pain state, the detailed molecular mechanisms of which remain unclear. In the present study, Shank3 was found to play an important role in neuropathic pain in rats following spared nerve injury (SNI). Shank3 was upregulated in the spinal dorsal horn of rats subjected to SNI, ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Zhang X,Li X,Wang H,Xie X,Li Y,Xu X,Su S,Zhao H,Li J,Ke C,Liu J

    更新日期:2020-05-23 00:00:00

  • Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing.

    abstract::Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Paquette T,Tokunaga R,Touj S,Leblond H,Piché M

    更新日期:2019-12-01 00:00:00

  • Sex difference in the expression and regulation of nitric oxide synthase gene in the rat preoptic area.

    abstract::Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ishihara T,Orikasa C,Araki T,Sakuma Y

    更新日期:2002-06-01 00:00:00

  • Impairment of active avoidance produced after destruction of pedunculopontine nucleus areas in the rat.

    abstract::Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Fujimoto K,Yoshida M,Ikeguchi K,Niijima K

    更新日期:1989-04-01 00:00:00

  • Zinc ion as modulator effects on excitability and synaptic transmission in hippocampal CA1 neurons in Wistar rats.

    abstract::Zinc is one of trace elements that play essential roles in several cell functions, and is unquestionably important to the normal health and function of the central nervous system. Growing evidence suggests that Zn(2+) can become a pathogenic agent in certain neurological disease states, such as ischemia, seizures, and...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tian Y,Yang Z,Zhang T

    更新日期:2010-11-01 00:00:00

  • Neuromagnetic correlates of hemispheric specialization for face and word recognition.

    abstract::The adult human brain appears to have specialized and independent neural systems for the visual processing of faces and words: greater selectivity for faces in the right hemisphere (RH) while greater selectivity for words in the left hemisphere (LH). Nevertheless, the nature of functional differences between the hemis...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Inamizu S,Yamada E,Ogata K,Uehara T,Kira JI,Tobimatsu S

    更新日期:2020-07-01 00:00:00

  • Change in phase synchronization of local field potentials in anesthetized rats after chronic dopamine depletion.

    abstract::In order to investigate temporal characteristics of oscillatory neural activity and the effect of chronic dopamine depletion on it, local field potentials were measured in anesthetized rats without or with a 6-OHDA lesion at either the ventral tegmental area or the substantia nigra compacta, using a pair of electrodes...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lee KM,Ahn TB,Jeon BS,Kim DG

    更新日期:2004-06-01 00:00:00

  • Depending on the mode of application morphine enhances or depresses somatocardiac sympathetic A- and C-reflexes in anesthetized rats.

    abstract::The effects of morphine on the reflex discharges in sympathetic efferents recorded from branches of the inferior cardiac nerve (ICN) were studied in rats anesthetized with alpha-chloralose and urethane. Somatocardiac sympathetic A- and C-reflexes were elicited by single shock electrical stimulation of myelinated (A) a...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Adachi T,Sato A,Sato Y,Schmidt RF

    更新日期:1992-12-01 00:00:00

  • Short-term potentiation at the parallel fiber-Purkinje cell synapse.

    abstract::Changes in synaptic efficacy at the parallel fiber (PF)-Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lastin...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Goto J,Inoue T,Kuruma A,Mikoshiba K

    更新日期:2006-05-01 00:00:00

  • Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

    abstract::The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

    更新日期:2011-04-01 00:00:00

  • Unmasking of silent "task-related" neuronal activity in the monkey prefrontal cortex by a GABA(A) antagonist.

    abstract::To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sawaguchi T

    更新日期:2001-01-01 00:00:00

  • Variety of morphological and electrophysiological properties of area postrema neurons in adult rat brain slices.

    abstract::Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Funahashi M,Mitoh Y,Akaike T,Matsuo R

    更新日期:2006-01-01 00:00:00