Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

Abstract:

:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Watanabe A,Kato N,Kato T

doi

10.1016/s0168-0102(02)00007-x

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

279-85

issue

4

eissn

0168-0102

issn

1872-8111

pii

S016801020200007X

journal_volume

42

pub_type

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