Abstract：
:We suggest a time-varying partial correlation as a statistical measure of dynamic functional connectivity (dFC) in the human brain. Traditional statistical models often assume specific distributions on the measured data such as the Gaussian distribution, which prohibits their application to neuroimaging data analysis. First, we use the copula-based dynamic conditional correlation (DCC), which does not rely on a specific distribution assumption, for estimating time-varying correlation between regions-of-interest (ROIs) of the human brain. Then, we suggest a time-varying partial correlation based on the Gaussian copula-DCC-GARCH model as an effective method for measuring dFC in the human brain. A recursive algorithm is explained for computation of the time-varying partial correlation. Numerical simulation results demonstrate effectiveness of the partial correlation-based methods against pairwise correlation-based methods. In addition, a two-step procedure is described for the inference of sparse dFC structure using functional magnetic resonance imaging (fMRI) data. We illustrate the proposed method by analyzing an fMRI data set of human participants watching a Pixar animated movie. Based on twelve a priori selected brain regions in the cortex, we demonstrate that the proposed method is effective for inferring sparse dFC network structures and robust to noise distribution and a preprocessing step of fMRI data.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Lee N,Kim JMdoi
10.1016/j.neures.2020.06.006subject
Has Abstractpub_date
2020-07-03 00:00:00eissn
0168-0102issn
1872-8111pii
S0168-0102(20)30396-5pub_type
杂志文章abstract：:The effects of acupuncture-like stimulation of the various segmental areas on gastric motility were examined in anesthetized rats. An acupuncture needle (diameter 340 microns) was inserted into the skin and underlying muscles at a depth of 4-5 mm and was twisted right and left once every second for 60 s. Gastric motil...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90105-y
更新日期：1993-10-01 00:00:00
abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.12.019
更新日期：2021-01-01 00:00:00
abstract：:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.02.002
更新日期：2013-04-01 00:00:00
abstract：:To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00107-8
更新日期：2000-01-01 00:00:00
abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.10.001
更新日期：2005-02-01 00:00:00
abstract：:Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.07.002
更新日期：2006-10-01 00:00:00
abstract：:A glial cell line designated as B2 was generated from primary cultures of oligodendrocytes/astrocytes isolated from an adult BALB/c mouse brain and maintained for over 1 year. Phenotypic characteristics of B2 cells were investigated by immunolabeling with cell type-specific markers for oligodendrocytes (O4 and galacto...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90035-3
更新日期：1994-08-01 00:00:00
abstract：:Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.11.002
更新日期：2018-03-01 00:00:00
abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.007
更新日期：2018-04-01 00:00:00
abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90018-7
更新日期：1989-12-01 00:00:00
abstract：:The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90060-x
更新日期：1986-09-01 00:00:00
abstract：:The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90026-9
更新日期：1992-10-01 00:00:00
abstract：:The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.02.006
更新日期：2015-05-01 00:00:00
abstract：:Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.11.012
更新日期：2018-01-01 00:00:00
abstract：:Immunohistochemical staining for GD3 in adult rat brain was carried out using mouse IgM anti-GD3 monoclonal antibody (DSG-1). Neuronal cells in the cerebral cortex, striatum, hippocampus and various nuclei of the thalamus were immunoreactive. In the cerebellum, Purkinje cells, granule cells and also basket cells were ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90134-1
更新日期：1994-03-01 00:00:00
abstract：:The hypothalamic paraventricular nuclei (PVN) inhibits spinal nociception. Furthermore, projections from the PVN to other structures related to pain modulation exist, but a functional interaction has not yet been fully demonstrated. As an initial approach, we show here that PVN electric stimulation with the same param...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.04.004
更新日期：2015-09-01 00:00:00
abstract：:Responses from 2-4 muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles were simultaneously recorded in cats anaesthetized with alpha-chloralose. It was demonstrated that stretch of the anterior cruciate ligament (ACL) of the ipsilateral knee causes changes in dynamic and/or s...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90057-l
更新日期：1990-04-01 00:00:00
abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)00864-c
更新日期：1995-02-01 00:00:00
abstract：:Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90047-7
更新日期：1994-05-01 00:00:00
abstract：:It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.02.005
更新日期：2010-06-01 00:00:00
abstract：:The present study focused on the early stages of acute glutamate (L-Glu)-induced neurotoxic mechanisms, both biochemical, e.g. intracellular reactive oxygen species (ROS) and associated parameters as well as gene expression of cell survival/death pathways, i.e. Bcl-2 and caspases. Stereotactic intracortical injections...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.11.009
更新日期：2010-03-01 00:00:00
abstract：:In anesthetized and immobilized Japanese monkeys (Macaca fuscata), intraretinal conduction velocities of the ganglion cell axons were measured. The field potentials elicited by optic chiasm shocks consisted of fast and slow components with estimated conduction velocities of 1.19 and 0.72 m/s in recordings from the opt...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90006-5
更新日期：1988-10-01 00:00:00
abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.01.008
更新日期：2012-04-01 00:00:00
abstract：:Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.11.002
更新日期：2007-03-01 00:00:00
abstract：:The effect of diazepam (DZP) on the GABA-induced macroscopic and microscopic Cl- current was investigated in isolated frog sensory neurons using both 'concentration-clamp' and patch-clamp techniques. At concentration range between 10(-9) and 10(-4) M, DZP itself evoked no response but potentiated time- and dose-depend...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90023-0
更新日期：1989-04-01 00:00:00
abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.09.007
更新日期：2008-01-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a recently identified member of the secretin/vasoactive intestinal polypeptide (VIP) family. There are at least two types of receptor for PACAP: type I (PACAPR), which specifically binds PACAP; and type II (VIP/PACAPR), which binds both PACAP and VIP. The l...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00065-5
更新日期：1997-08-01 00:00:00
abstract：:We investigated how much time wild-type Caenorhabditis elegans (Bristol N2) nematodes and the GABA-deficient unc25 mutant and the vesicular GABA transporter-deficient unc47 mutant spent moving. The worms were allowed to move freely on the surface of agarose plates either with or without the food bacterium OP50. We ide...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00148-6
更新日期：2000-09-01 00:00:00
abstract：:Effects of 1-naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors were studied in cultured rat hippocampal neurons using the whole-cell patch clamp technique. A population of cultured neurons had ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00067-9
更新日期：1997-09-01 00:00:00
