Abstract：
:The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding of astrocytes include new observations about their structure, organization, function and supportive actions to other cells. Although the contribution of astrocytes to the process of brain injury has not been clearly defined, it is thought that their ability to provide support to neurons after cerebral damage is critical. Astrocytes play a fundamental role in the pathogenesis of brain injury-associated neuronal death, and this secondary injury is primarily a consequence of the failure of astrocytes to support the essential metabolic needs of neurons. These needs include K+ buffering, glutamate clearance, brain antioxidant defense, close metabolic coupling with neurons, and the modulation of neuronal excitability. In this review, we will focus on astrocytic activities that can both protect and endanger neurons, and discuss how manipulating these functions provides a novel and important strategy to enhance neuronal survival and improve the outcome following brain injury.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Barreto GE,Gonzalez J,Torres Y,Morales Ldoi
10.1016/j.neures.2011.06.004subject
Has Abstractpub_date
2011-10-01 00:00:00pages
107-13issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(11)00160-Xjournal_volume
71pub_type
杂志文章,评审abstract：:The role of GABA in medial preoptico-anterior hypothalamic area in the regulation of spontaneous sleep-wakefulness and rapid eye movement sleep was investigated in this study. Local microinjection of picrotoxin, a GABA-A antagonist, into this area increased quiet wakefulness but significantly reduced deep sleep and ra...
journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience research
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pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1988-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.11.012
更新日期：2018-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.10.004
更新日期：2008-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00213-x
更新日期：2003-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00061-9
更新日期：1999-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00107-2
更新日期：1999-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2012.02.012
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.10.020
更新日期：2007-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(84)90009-9
更新日期：1984-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2020.05.005
更新日期：2020-05-24 00:00:00
abstract：:Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for the maternal immune activation background in patients with neurodevelopmental disorders h...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.07.003
更新日期：2016-12-01 00:00:00
