Abstract:
:The role of GABA in medial preoptico-anterior hypothalamic area in the regulation of spontaneous sleep-wakefulness and rapid eye movement sleep was investigated in this study. Local microinjection of picrotoxin, a GABA-A antagonist, into this area increased quiet wakefulness but significantly reduced deep sleep and rapid eye movement sleep. Both the frequency of generation and duration per episode of the latter were significantly reduced. It is concluded that GABA-ergic neurotransmission in the medial preoptic area is spontaneously active in modulating the hypnogenic function including rapid eye movement sleep and the action is mediated by GABA-A receptor.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ali M,Jha SK,Kaur S,Mallick BNdoi
10.1016/s0168-0102(99)00013-9subject
Has Abstractpub_date
1999-03-01 00:00:00pages
245-50issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(99)00013-9journal_volume
33pub_type
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