Abstract：
:Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. The ensemble noise analysis of I[K(Ca)], which was evoked following the activation of presynaptic Ca2+ current, revealed that the single channel conductance and open probability (P(o)) were approximately 50 pS ([K+]o = 2.6 mM, [K+]i = 140 mM) and 0.6 at 0 mV, respectively. To estimate [Ca2+]i at the cytosolic side of BK channels, activation of I[K(Ca)] was examined in Ca2+-loaded bipolar cells bathed in Co2+ solution. [Ca2+]i was monitored using furaptra fluorimetry. It was found that [Ca2+]i ranged between 10 and 20 microM when P(o) was 0.6. A high concentration of BAPTA ( > 20 mM) was required to suppress I[K(Ca)]. Under this condition, channel number was reduced without changing P(o). Therefore, it is likely that some BK channels are co-localized with Ca2+ channels in presynaptic terminals of retinal bipolar cells.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Sakaba T,Ishikane H,Tachibana Mdoi
10.1016/s0168-0102(97)01155-3subject
Has Abstractpub_date
1997-03-01 00:00:00pages
219-28issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(97)01155-3journal_volume
27pub_type
杂志文章abstract：:Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.10.006
更新日期：2014-02-01 00:00:00
abstract：:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.002
更新日期：2018-08-01 00:00:00
abstract：:To examine whether mossy fibers (MFs) in the cerebellar hemisphere show delay activity, we recorded MF activity during a wrist movement task with a random instructed delay period in two monkeys. Among 155 task-related MFs, 70 MFs (45%) demonstrated significant delay activity. Those MFs were widely distributed in the c...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.07.006
更新日期：2014-10-01 00:00:00
abstract：:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90081-z
更新日期：1993-02-01 00:00:00
abstract：:Interleukin-6 (IL-6, human recombinant) promoted the survival of catecholaminergic neurons from fetal and postnatal rat midbrains as assessed by an immunohistochemical staining for tyrosine hydroxylase (TH) in culture using a chemically defined medium. The maximal dose of IL-6 for the cell survival of postnatal P15 ra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90039-f
更新日期：1992-05-01 00:00:00
abstract：:Dopaminergic neurons of the substantia nigra pars compacta play a major role in goal-directed behavior and reinforcement learning. The study of their local interactions has revealed that they are connected by electrical synapses. Connexins, the molecular substrate of electrical synapses, constitute a multigenic family...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.013
更新日期：2006-12-01 00:00:00
abstract：:Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.05.007
更新日期：2019-06-01 00:00:00
abstract：:Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.06.007
更新日期：2009-10-01 00:00:00
abstract：:We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.03.008
更新日期：2015-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.12.006
更新日期：2020-07-01 00:00:00
abstract：:The hypothalamic paraventricular nuclei (PVN) inhibits spinal nociception. Furthermore, projections from the PVN to other structures related to pain modulation exist, but a functional interaction has not yet been fully demonstrated. As an initial approach, we show here that PVN electric stimulation with the same param...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.04.004
更新日期：2015-09-01 00:00:00
abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00255-3
更新日期：2001-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00198-5
更新日期：2001-04-01 00:00:00
abstract：:The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.007
更新日期：2008-07-01 00:00:00
abstract：:Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary mo...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.05.009
更新日期：2014-08-01 00:00:00
abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.018
更新日期：2011-04-01 00:00:00
abstract：:The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90039-9
更新日期：1988-08-01 00:00:00
abstract：:Damage to the central nervous system (CNS) leads to disruption of the vascular network, causing vascular dysfunction. Vascular dysfunction is the major event in the pathogenesis of CNS diseases and is closely associated with the severity of neuronal dysfunction. The suppression of vascular dysfunction has been conside...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2014.01.007
更新日期：2014-04-01 00:00:00
abstract：:The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00288-7
更新日期：2001-11-01 00:00:00
abstract：:Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(84)80008-5
更新日期：1984-04-01 00:00:00
abstract：:The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.09.005
更新日期：2016-04-01 00:00:00
abstract：:The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.09.005
更新日期：2006-12-01 00:00:00
abstract：:Sizes of neuronal somata in the cat cervical dorsal root ganglia were determined at different levels (C1-C8). The average value and class distribution of mean cell diameter were analyzed. The ganglia from C1 to C5 could be clearly distinguished from those at levels of brachial plexus afferents (C6-C8) with respect to ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90009-4
更新日期：1990-02-01 00:00:00
abstract：:Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:Hippocampal neurogenesis is influenced by many factors. In this study, we examined the effect of tactile stimulation (tickling), which induced positive emotion, on neurogenesis in the dentate gyrus (DG) of the hippocampus. Four week-old rats were tickled for 5 min/day on 5 consecutive days and received 5-bromo-2'-deox...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00208-0
更新日期：2003-02-01 00:00:00
abstract：:We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to ident...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.013
更新日期：2008-07-01 00:00:00
abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)00864-c
更新日期：1995-02-01 00:00:00
abstract：:The pattern of distribution of cholinergic fibers was examined immunohistochemically in the cat superior colliculus by using a monoclonal antibody against choline acetyltransferase (ChAT). In the superficial layers, an obvious immunoreactive zone was found in the rostral two-thirds of the outer portion of the superfic...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90004-7
更新日期：1989-06-01 00:00:00
abstract：:Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00033-9
更新日期：1998-06-01 00:00:00
