Abstract：
:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with MI owing to advanced age and/or higher-cognitive dysfunction, thus impairing their ability to internally simulate the action. We therefore investigated whether action observation (AO), an alternative form of motor stimulation that works via the mirror-neuron system, could facilitate motor cortical activity in such patients. Combined AO and physical training of the observed actions has been reported to have a positive impact on motor deficits after stroke. Eleven patients with stroke and hemiplegia affecting the hand performed MI and AO with verbal and video instructions under 19 channels of electroencephalogram (EEG) recording. The event-related desynchronization (ERD) was measured as an electroencephalographic marker of motor cortical activity. The ERD power in the AO condition (30.0±5.0%) was significantly higher than that in the MI condition (12.2±3.9%). These results suggest that AO could be a good option for patients with stroke who have difficulty using MI to effectively stimulate and reestablish cortical-peripheral motor pathways.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Tani M,Ono Y,Matsubara M,Ohmatsu S,Yukawa Y,Kohno M,Tominaga Tdoi
10.1016/j.neures.2017.10.002subject
Has Abstractpub_date
2018-08-01 00:00:00pages
7-14eissn
0168-0102issn
1872-8111pii
S0168-0102(17)30277-8journal_volume
133pub_type
杂志文章abstract：:The contribution of intrinsic balance control factors to fall mechanisms has received little investigation in studies on occupational accidents. The aim of this study was to assess whether postural regulation in falling workers might have specificities in terms of sensorimotor strategies and neuromuscular responses to...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.11.001
更新日期：2004-03-01 00:00:00
abstract：:Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a granular tau oligomer having a pre-filamentous structure. To determine the role of this oligomer in NFT formation, we quantified the amount of gr...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.11.009
更新日期：2006-03-01 00:00:00
abstract：:Spinal cord injury (SCI) is a serious condition often affecting young and healthy individuals around the world. Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in SCI, but the underlying mechanism remains largely unknown especially regarding neural specific proteins ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.04.012
更新日期：2010-08-01 00:00:00
abstract：:GABAergic characteristics of transcallosal activity of cat pyramidal tract neurons (PTNs) and non-PTNs (nPTNs) were studied with stressing on GABAB receptors. PTNs and nPTNs were further classified into group 1 (< 10 ms) and group 2 (> 10 ms) based on the latency upon transcallosal stimulation. However, mainly the res...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01112-1
更新日期：1996-12-01 00:00:00
abstract：:Efferent neurons to the cochlea in the guinea pig were observed in the superior olivary complex and ventral lateral lemniscal nuclei after injection of WGA-HRP into the cochlea via the round window. Of HRP-labeled nerve cells found in the brainstem, about 60% and 10% were located in the ipsilateral lateral superior ol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(88)90003-x
更新日期：1988-10-01 00:00:00
abstract：:Using Mayahara's method, the distribution of K(+)-dependent p-nitrophenylphosphatase activity was examined electron microscopically in the synaptic regions of the cerebral cortex of 10, 15 and 60-day-old Wistar rats. The enzyme achieved gradually its characteristic localization and uniform distribution. The main devel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)01004-1
更新日期：1996-02-01 00:00:00
abstract：:γ-Aminobutyric acid (GABA) generally induces hyperpolarization and inhibition in the adult brain, but causes depolarization (and can be excitatory) in the immature brain. Depolarizing GABA actions are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Additionally, the conversion of GABA respo...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2020.02.010
更新日期：2020-07-01 00:00:00
abstract：:GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01102-9
更新日期：1996-10-01 00:00:00
abstract：:Increased levels of proinflammatory cytokines have been implicated in schizophrenia; however, their pathophysiological roles in abnormal brain dysfunctions remain unclear. We evaluated the effect of proinflammatory cytokines on a high-fat diet (HFD)-induced prepulse inhibition (PPI) deficits in the acoustic startle re...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.10.004
更新日期：2019-10-01 00:00:00
abstract：:Fifteen rabbits were classically conditioned using stimulation of the right pontine nuclei as a conditioned stimulus and a corneal airpuff as an unconditioned stimulus. After conditioning criterion was reached, the stimulation conditioned stimulus was transferred to the left pontine nuclei and the rate of conditioned ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90057-x
更新日期：1986-09-01 00:00:00
abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.06.013
更新日期：2006-10-01 00:00:00
abstract：:Many studies on long-term potentiation (LTP) in hippocampal region CA1 focus on receptor-mediated events that are often presumed to be linked to postsynaptic processes. Whereas it is now well-known that LTP consists of multiple components involving increases in postsynaptic responsiveness as well as enhanced presynapt...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00986-8
更新日期：1996-01-01 00:00:00
abstract：:Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...
journal_title：Neuroscience research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neures.2006.09.004
更新日期：2007-01-01 00:00:00
abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00025-1
更新日期：2002-06-01 00:00:00
abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.009
更新日期：2008-07-01 00:00:00
abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00897-2
更新日期：1995-05-01 00:00:00
abstract：:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.03.016
更新日期：2009-07-01 00:00:00
abstract：:The structure of dendritic spines determines synaptic efficacy, a plastic process that mediates information processing in the vertebrate nervous system. Aberrant spine morphology, including alterations in shape, size, and number, are common in different brain diseases. Because of this, accurate and unbiased characteri...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2015.02.007
更新日期：2015-07-01 00:00:00
abstract：:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.02.002
更新日期：2013-04-01 00:00:00
abstract：:The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-prol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90042-w
更新日期：1991-08-01 00:00:00
abstract：:Axonal transport is the specialized and well-developed intracellular transport system for regulated and/or long-distance transport based on generalized cellular machineries. Among them, slow axonal transport conveys cytoplasmic proteins. The motor molecule, the nature of transporting complex and the transport regulati...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2003.08.005
更新日期：2003-12-01 00:00:00
abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00065-8
更新日期：2003-07-01 00:00:00
abstract：:To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00204-2
更新日期：2001-01-01 00:00:00
abstract：:The subgranular zone (SGZ) in the dentate gyrus contains radial astrocytes, known as Type-1 or Type-B cells, which generate neuroblasts (Type-2 cells or Type-D cells) that give rise to granular neurons. Stress increases glucocorticoid levels that target SGZ and modify the proliferation and apoptosis of hippocampal cel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.03.013
更新日期：2011-07-01 00:00:00
abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.11.007
更新日期：2007-03-01 00:00:00
abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.01.008
更新日期：2012-04-01 00:00:00
abstract：:Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary mo...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.05.009
更新日期：2014-08-01 00:00:00
abstract：:To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90062-j
更新日期：1990-06-01 00:00:00
abstract：:The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90026-9
更新日期：1992-10-01 00:00:00
abstract：:The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.08.001
更新日期：2012-10-01 00:00:00
