Abstract：
:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the expression of both brain-derived neurotrophic factor (BDNF) mRNA and BDNF, suggesting that activated-p38 MAPK(+)/ED1(+) cells would produce BDNF and may exhibit trophic effect on the degenerating neurons in the SN. However, in ELISA, BDNF protein decreased significantly in ipsilateral SN at 7 days after hemorrhage, which may be due to a dramatic decrease of BDNF immunoreactive neurons in pars compacta. Data suggest that activation of p38 MAPK in ED1(+) cells infiltrating in ipsilateral SN after hemorrhage may produce BDNF, but that the amount of BDNF produced from ED1(+) cells is insufficient for the rescue of degenerating neurons.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Imamura N,Hida H,Aihara N,Ishida K,Kanda Y,Nishino H,Yamada Kdoi
10.1016/s0168-0102(03)00065-8subject
Has Abstractpub_date
2003-07-01 00:00:00pages
289-98issue
3eissn
0168-0102issn
1872-8111pii
S0168010203000658journal_volume
46pub_type
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