Abstract：
:Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and/or receptor binding of opioid peptides. We studied the effects of a single acute dose of ethanol on rat nigrostriatal mu opioid receptors by quantitative receptor autoradiography, using [3H] [D-Ala(2),MePhe(4),Gly-ol(5)]-enkephalin ([3H]-DAMGO) as radioligand. [3H]-DAMGO binding was significantly decreased in the pars reticulata of the substantia nigra 1 h after ethanol administration. Ethanol exposure did not affect [3H]-DAMGO binding neither in the pars compacta of the substantia nigra nor in the caudate-putamen at any time tested after drug administration. The observed effects may reflect ethanol-induced changes in ligand binding affinity (Kd) or in receptor density (Bmax). Early and transitory ethanol-induced changes of mu receptors in the substantia nigra pars reticulata may be related to regulation of dopaminergic nigrostriatal transmission and contribute to determine brain sensitivity to the drug.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Méndez M,Leriche M,Carlos Calva Jdoi
10.1016/s0168-0102(03)00188-3subject
Has Abstractpub_date
2003-10-01 00:00:00pages
153-60issue
2eissn
0168-0102issn
1872-8111pii
S0168010203001883journal_volume
47pub_type
杂志文章abstract：:The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...
journal_title：Neuroscience research
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pub_type： 杂志文章
doi：10.1016/j.neures.2007.06.1467
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0168-0102(86)90060-x
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.10.020
更新日期：2007-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2000-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.09.009
更新日期：2015-03-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00953-1
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.013
更新日期：2006-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.06.021
更新日期：2005-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
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doi：10.1016/s0168-0102(99)00010-3
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journal_title：Neuroscience research
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更新日期：2005-12-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2016-04-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2014-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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