Migration and differentiation of neural cell lines transplanted into mouse brains.


:In the past few years, the plasticity of the regional specification of the CNS has been widely debated on the results from in utero transplantation. Two different results are reported with this transplantation method. One is that the distribution of transplanted cells is dependent on the donor origin, and the other is that the distribution is independent on the donor cell origin. The present study attempted to examine closely the plasticity of the regional specification by in utero transplantation method with clonal neural cell lines, 2Y-3t and 2Y-5o2b. These lines were established from a cerebellum of an adult p53-deficient mouse. Our results showed that transplanted cells migrated into various regions of the CNS and supported the independent distribution. Moreover, different distribution patterns of transplanted cells were observed between host sexes. Labeled cells were localized around the ventricle of neonatal host brains, where they were undifferentiated. In 2-3 weeks after birth, labeled cells were found in the brain parenchyma and some of them took neuronal morphology. In the rostral migratory stream (RMS), cells with unipolar or bipolar morphology were still undifferentiated. In other regions, labeled cells were often associated with blood vessels; the soma were on the surface of vessels, extending processes or neurites into surrounding brain parenchyma. Time-lapse imaging demonstrated that they were migrating with blood vessels.


Neurosci Res


Neuroscience research


Honda S,Toda K,Tozuka Y,Yasuzawa S,Iwabuchi K,Tomooka Y




Has Abstract


2007-10-01 00:00:00














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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Koike T,Kan S,Misaki M,Miyauchi S

    更新日期:2011-04-01 00:00:00

  • The effects of D-alpha-aminoadipic acid on long-term potentiation in the hippocampus of the rat in vitro.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hicks TP,Ito KI

    更新日期:1996-01-01 00:00:00

  • Phasic nicotinic potentiation of frog retinotectal transmission enhances intrinsic activity of tectum column.

    abstract::It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

    journal_title:Neuroscience research

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    authors: Baginskas A,Kuraite V,Kuras A

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  • Nerve growth factor-like activity in the rat pituitary intermediate lobe.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Soinila S,Lakshmanan J,Lahtinen T

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  • An electrochemical microprobe for detecting nitric oxide release in brain tissue.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Shibuki K

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  • Transplantation of human dental pulp stem cells compensates for striatal atrophy and modulates neuro-inflammation in 3-nitropropionic acid rat model of Huntington's disease.

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    authors: Eskandari N,Boroujeni ME,Abdollahifar MA,Piryaei A,Khodagholi F,Mirbehbahani SH,Siroosi S,Moghaddam MH,Aliaghaei A,Sadeghi Y

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  • Correlation between anti-ubiquitin immunoreactivity and region-specific neuronal death in N-methyl-D-aspartate-treated rat hippocampal organotypic cultures.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Okada M,Sakaguchi T,Kawasaki K

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  • Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat central nervous system.

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    journal_title:Neuroscience research

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    authors: Kanazawa I,Ogawa T,Kimura S,Munekata E

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  • Ischemia induces cell proliferation and neurogenesis in the gerbil hippocampus in response to neuronal death.

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    authors: Salazar-Colocho P,Lanciego JL,Del Rio J,Frechilla D

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  • Functional roles of the superior laryngeal nerve afferents in electrically induced vocalization in anesthetized cats.

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    journal_title:Neuroscience research

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    authors: Shiba K,Yoshida K,Miura T

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  • Spectral dissociation of lateralized brain rhythms.

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    authors: Inamizu S,Yamada E,Ogata K,Uehara T,Kira JI,Tobimatsu S

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    authors: Gulino R,Gulisano M

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    authors: Shirao T,Sekino Y

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  • Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model.

    abstract::A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

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    authors: Siwach P,Sengupta S,Parihar R,Ganesh S

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  • Neuronal connections between the auricular skin and the sympathetic pre- and postganglionic neurons of the dog as studied by using pseudorabies virus.

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    journal_title:Neuroscience research

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    authors: Chien CH,Shieh JY,Liao MH,Ling EA,Wen CY

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  • Decreased EEG synchronization and its correlation with symptom severity in Alzheimer's disease.

    abstract:BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

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    authors: Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

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    abstract::Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduc...

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    pub_type: 杂志文章,评审


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  • Modeling and analysis of spatio-temporal change in [Ca2+]i in a retinal rod outer segment.

    abstract::The change in [Ca2+]i, in a retinal rod outer segment to flash and step stimuli was simulated. The present model included inward and outward calcium fluxes through cation channels and an Na-Ca-K exchanger, respectively, calcium buffers, and diffusion through the interdiskal space of cytoplasm and incisures. Under cont...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ichikawa K

    更新日期:1996-06-01 00:00:00

  • N1 and N2 ERPs reflect the regulation of automatic approach tendencies to positive stimuli.

    abstract::The Approach-Avoidance Task (AAT) measures automatic approach-avoidance tendencies and their regulation: compatible reactions (approach positive, avoid negative) are faster than incompatible ones (approach negative, avoid positive). The present study assessed event-related potentials (ERPs) in 15 healthy persons for d...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ernst LH,Ehlis AC,Dresler T,Tupak SV,Weidner A,Fallgatter AJ

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    pub_type: 杂志文章


    authors: Kawai K,Mori M,Watarai S,Yasuda T

    更新日期:1994-03-01 00:00:00

  • Axon collaterals of anterior semicircular canal-activated vestibular neurons and their coactivation of extraocular and neck motoneurons in the cat.

    abstract::We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Uchino Y,Hirai N

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  • Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.

    abstract::Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measure...

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    authors: Takahashi H,Iwase M,Ishii R,Ohi K,Fukumoto M,Azechi M,Ikezawa K,Kurimoto R,Canuet L,Nakahachi T,Iike N,Tagami S,Morihara T,Okochi M,Tanaka T,Kazui H,Yoshida T,Tanimukai H,Yasuda Y,Kudo T,Hashimoto R,Takeda M

    更新日期:2008-11-01 00:00:00

  • Anisotropic functional connections between the auditory cortex and area 18a in rat cerebral slices.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hishida R,Hoshino K,Kudoh M,Norita M,Shibuki K

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  • Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation.

    abstract::Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lin SH,Miyata S,Weng W,Matsunaga W,Ichikawa J,Furuya K,Nakashima T,Kiyohara T

    更新日期:1998-12-01 00:00:00