Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum.

abstract：:Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the n...

journal_title：Neuroscience research

authors： Candelario-Jalil E,Alvarez D,Merino N,León OS

更新日期：2003-10-01 00:00:00

abstract：:By combining biochemical, molecular and immunohistochemical approaches, we have investigated the presence of metabotropic glutamate receptors (mGluRs) belonging to the subtype 5 in rat and human spinal cords and the developmental changes in their expression. A polyclonal antibody raised against the carboxy-terminal po...

journal_title：Neuroscience research

authors： Valerio A,Rizzonelli P,Paterlini M,Moretto G,Knöpfel T,Kuhn R,Memo M,Spano P

更新日期：1997-05-01 00:00:00

abstract：:The purpose of this study was to investigate electrophysiological correlates related to the recognition of repeated faces in the intact human by means of event-related brain potentials (ERPs). A group of young healthy adults performed a continuous face recognition task, in which 240 unfamiliar faces were flashed upon ...

journal_title：Neuroscience research

authors： Münte TF,Brack M,Grootheer O,Wieringa BM,Matzke M,Johannes S

更新日期：1997-07-01 00:00:00

abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...

journal_title：Neuroscience research

authors： Tsai YJ,Leong SM,Day AS,Wen CY,Shieh JY,Lue JH

更新日期：2004-04-01 00:00:00

abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...

journal_title：Neuroscience research

authors： Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

更新日期：2002-08-01 00:00:00

abstract：:In order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (LH) concentrations were measured in female rats after making lesions in this nucleus (DRL) and/or treatment with 5-hydroxytryptamine (5-HT) receptor...

journal_title：Neuroscience research

authors： Maekawa F,Tsukahara S,Tsukamura H,Maeda KI,Yamanouchi K

更新日期：1999-12-30 00:00:00

abstract：:Our purpose was to elucidate the functional roles of the laryngeal afferents in controlling vocalization. We investigated the effects of laryngeal deafferentation (sectioning the internal branch of the superior laryngeal nerve (ISLN)) on respiration and voice quality during electrically-induced vocalization in twelve ...

journal_title：Neuroscience research

authors： Shiba K,Yoshida K,Miura T

更新日期：1995-03-01 00:00:00

abstract：:Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...

journal_title：Neuroscience research

authors： Salimi K,Moser K,Zassler B,Reindl M,Embacher N,Schermer C,Weis C,Marksteiner J,Sawada M,Humpel C

更新日期：2002-07-01 00:00:00

abstract：:Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...

journal_title：Neuroscience research

authors： Ito Y,Honda A,Igarashi M

更新日期：2018-03-01 00:00:00

abstract：:Responses of Purkinje cells to parallel fibre stimulation and to ionophoretically applied glutamate agonists, L-glutamate, L-aspartate, quisqualate, kainate and N-methyl-D-aspartate (NMDA), were extracellularly recorded in a superficial folium of the dorsal paraflocculus of high-decerebrate rabbits. NMDA caused an inh...

journal_title：Neuroscience research

authors： Kano M,Kato M,Chang HS

更新日期：1988-04-01 00:00:00

abstract：:Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie con...

journal_title：Neuroscience research

authors： Northoff G,Mushiake H

更新日期：2020-07-01 00:00:00

abstract：:The change in [Ca2+]i, in a retinal rod outer segment to flash and step stimuli was simulated. The present model included inward and outward calcium fluxes through cation channels and an Na-Ca-K exchanger, respectively, calcium buffers, and diffusion through the interdiskal space of cytoplasm and incisures. Under cont...

journal_title：Neuroscience research

authors： Ichikawa K

更新日期：1996-06-01 00:00:00

abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...

journal_title：Neuroscience research

authors： Otsu M,Sai T,Nakayama T,Murakami K,Inoue N

更新日期：2011-04-01 00:00:00

abstract：:Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investig...

journal_title：Neuroscience research

authors： Schomburg ED,Steffens H,Pilyavskii AI,Maisky VA,Brück W,Dibaj P,Sears TA

更新日期：2015-06-01 00:00:00

abstract：:Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

journal_title：Neuroscience research

authors： Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

更新日期：2016-11-01 00:00:00

abstract：:In rat hippocampal CA1 neurons recorded intracellularly from tissue slices, a rapid depolarization occurred approximately 5 min after application of ischemia-simulating medium. In extracellular recordings obtained from CA1 region, a rapid negative-going DC potential (rapid DC potential) was recorded, corresponding to ...

journal_title：Neuroscience research

authors： Uchikado H,Tanaka E,Yamamoto S,Isagai T,Shigemori M,Higashi H

更新日期：2000-02-01 00:00:00

abstract：:Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune re...

journal_title：Neuroscience research

authors： Ding L,Meng Y,Zhang HY,Yin WC,Yan Y,Cao YP

更新日期：2017-06-01 00:00:00

abstract：:Detergent-unextractable structures of synaptic plasma membrane of rat cerebrum were observed by whole mount electron microscopy. The globular structures were identified as postsynaptic densities (PSDs) from several criteria and appeared to consist of folded strings, to which a number of other molecules might be attach...

journal_title：Neuroscience research

authors： Suzuki T,Tanaka R

更新日期：1986-02-01 00:00:00

abstract：:Adaptive changes in initial eye velocity of pursuit eye movement were examined in nine normal subjects using a target that moved in a multiple ramp fashion. Significant changes in initial eye velocity occurred rapidly after training in six of the subjects. The magnitude and direction of the induced changes were a func...

journal_title：Neuroscience research

authors： Fukushima K,Tanaka M,Suzuki Y,Fukushima J,Yoshida T

更新日期：1996-08-01 00:00:00

abstract：:Changes in synaptic efficacy at the parallel fiber (PF)-Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lastin...

journal_title：Neuroscience research

authors： Goto J,Inoue T,Kuruma A,Mikoshiba K

更新日期：2006-05-01 00:00:00

abstract：:Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Bl...

journal_title：Neuroscience research

authors： Pesce M,Rizzuto A,La Fratta I,Tatangelo R,Campagna G,Iannasso M,Ferrone A,Franceschelli S,Speranza L,Patruno A,De Lutiis MA,Felaco M,Grilli A

更新日期：2016-05-01 00:00:00

abstract：:Axonal transport is the specialized and well-developed intracellular transport system for regulated and/or long-distance transport based on generalized cellular machineries. Among them, slow axonal transport conveys cytoplasmic proteins. The motor molecule, the nature of transporting complex and the transport regulati...

journal_title：Neuroscience research

authors： Terada S

更新日期：2003-12-01 00:00:00

abstract：:Experiments were performed to study the projection of the group y of the vestibular nuclei and the dentate and fastigial nuclei of the cerebellum to the interstitial nucleus of Cajal (INC) in cats by using retrograde axonal transport of horseradish peroxidase (HRP) and electrophysiological methods; and to study the ve...

journal_title：Neuroscience research

authors： Fukushima K,Terashima T,Kudo J,Inoue Y,Kato M

更新日期：1986-05-01 00:00:00

abstract：:Because a potential treatment for brain injuries could be elevating magnesium ions (Mg(2+)) intracerebrally, we characterized the effects of elevating external Mg(2+) in cultures of neonatal murine brain-derived neural stem/progenitor cells (NSCs). Using a crystal violet assay, which avoids interference of Mg(2+) in t...

journal_title：Neuroscience research

authors： Vennemeyer JJ,Hopkins T,Kuhlmann J,Heineman WR,Pixley SK

更新日期：2014-07-01 00:00:00

abstract：:Neuropathic pain is a very complex chronic pain state, the detailed molecular mechanisms of which remain unclear. In the present study, Shank3 was found to play an important role in neuropathic pain in rats following spared nerve injury (SNI). Shank3 was upregulated in the spinal dorsal horn of rats subjected to SNI, ...

journal_title：Neuroscience research

authors： Zhang X,Li X,Wang H,Xie X,Li Y,Xu X,Su S,Zhao H,Li J,Ke C,Liu J

更新日期：2020-05-23 00:00:00

abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...

journal_title：Neuroscience research

authors： Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres A

更新日期：2008-07-01 00:00:00

abstract：:Fifteen rabbits were classically conditioned using stimulation of the right pontine nuclei as a conditioned stimulus and a corneal airpuff as an unconditioned stimulus. After conditioning criterion was reached, the stimulation conditioned stimulus was transferred to the left pontine nuclei and the rate of conditioned ...

journal_title：Neuroscience research

authors： Steinmetz JE,Rosen DJ,Woodruff-Pak DS,Lavond DG,Thompson RF

更新日期：1986-09-01 00:00:00

abstract：:RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the alpha3 subunit of the GABAA receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine. To ...

journal_title：Neuroscience research

authors： Nimmich ML,Heidelberg LS,Fisher JL

更新日期：2009-04-01 00:00:00

abstract：:Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

journal_title：Neuroscience research

authors： O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

更新日期：2010-02-01 00:00:00

abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...

journal_title：Neuroscience research

authors： Nakamura TJ,Shinohara K,Funabashi T,Mitsushima D,Kimura F

更新日期：2001-09-01 00:00:00