Short-term potentiation at the parallel fiber-Purkinje cell synapse.

abstract：:Confocal laser scanning microscopy (CLSM) was used to record spatial and dynamic changes in the intracellular Ca2+ [(Ca2+]i) of bullfrog sympathetic ganglion cells in excised tissue or in culture. A CLSM utilizing Ar ion laser (488 nm) and recording fluo-3 fluorescence yielded the sliced image of ganglion cells, while...

journal_title：Neuroscience research

authors： Kuba K,Hua SY,Nohmi M

更新日期：1991-05-01 00:00:00

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...

journal_title：Neuroscience research

authors： Hu C,Chen C,Chen J,Xiao K,Wang J,Shi Q,Ma Y,Gao LP,Wu YZ,Liu L,Xia Y,Yan P,Maimaitiming A,Zhou DH,Zhang LN,Chen ZB,Dong XP

更新日期：2021-01-01 00:00:00

abstract：:Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

journal_title：Neuroscience research

authors： Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

更新日期：2001-03-01 00:00:00

abstract：:Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...

journal_title：Neuroscience research

authors： Wang H,Tanaka Y,Kawauchi A,Miki T,Kayama Y,Koyama Y

更新日期：2012-01-01 00:00:00

abstract：:We investigated the distribution and colocalization pattern of the two corticosteroid receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the hippocampus and hypothalamus, the main target regions of corticosterone in the rat brain, using double immunofluorescence histochemistry in conjuncti...

journal_title：Neuroscience research

authors： Han F,Ozawa H,Matsuda K,Nishi M,Kawata M

更新日期：2005-04-01 00:00:00

abstract：:It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...

journal_title：Neuroscience research

authors： Huang FS,Abbas AK,Li R,Afanasenkau D,Wigström H

更新日期：2010-06-01 00:00:00

abstract：:Effective connectivity analysis has been widely applied to noninvasive recordings such as functional magnetic resonance imaging and electroencephalograms (EEGs). Previous studies have aimed to extract the causal relations between brain regions, but the validity of the derived connectivity has not yet been fully determ...

journal_title：Neuroscience research

authors： Ye S,Kitajo K,Kitano K

更新日期：2020-07-01 00:00:00

abstract：:Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...

journal_title：Neuroscience research

authors： Sakaba T,Ishikane H,Tachibana M

更新日期：1997-03-01 00:00:00

abstract：:Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...

journal_title：Neuroscience research

authors： Méndez M,Leriche M,Carlos Calva J

更新日期：2003-10-01 00:00:00

abstract：:The contribution of nociceptive Aδ-fibres and C-fibres of the central pad of the foot to nociceptive spinal flexor reflex pathways (FRA-type) and to nociceptive excitatory reflex pathways to foot extensors (non-FRA type) was investigated in high spinal cats. Persisting effects after complete blocking of A-fibres by te...

journal_title：Neuroscience research

authors： Schomburg ED,Dibaj P,Steffens H

更新日期：2011-03-01 00:00:00

abstract：:Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...

journal_title：Neuroscience research

authors： Amino T,Uchihara T,Tsunekawa H,Takahata K,Shimazu S,Mizusawa H,Orimo S

更新日期：2008-03-01 00:00:00

abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...

journal_title：Neuroscience research

authors： Imamura N,Hida H,Aihara N,Ishida K,Kanda Y,Nishino H,Yamada K

更新日期：2003-07-01 00:00:00

abstract：:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...

journal_title：Neuroscience research

authors： Tani M,Ono Y,Matsubara M,Ohmatsu S,Yukawa Y,Kohno M,Tominaga T

更新日期：2018-08-01 00:00:00

abstract：:In order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (LH) concentrations were measured in female rats after making lesions in this nucleus (DRL) and/or treatment with 5-hydroxytryptamine (5-HT) receptor...

journal_title：Neuroscience research

authors： Maekawa F,Tsukahara S,Tsukamura H,Maeda KI,Yamanouchi K

更新日期：1999-12-30 00:00:00

abstract：:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...

journal_title：Neuroscience research

authors： Noyama K,Maekawa S

更新日期：2003-02-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...

journal_title：Neuroscience research

authors： Mijangos-Moreno S,Poot-Aké A,Guzmán K,Arankowsky-Sandoval G,Arias-Carrión O,Zaldívar-Rae J,Sarro-Ramírez A,Murillo-Rodríguez E

更新日期：2016-04-01 00:00:00

abstract：:Opiates have been used extensively in the treatment of pain but with the severe side effect of addiction, which is believed to be related to opiates' direct (primary) or indirect (secondary) neurotoxicity. In this study, the effects of opioids on cell growth and apoptosis have been examined in human neuroblastoma cell...

journal_title：Neuroscience research

authors： Yin DL,Ren XH,Zheng ZL,Pu L,Jiang LZ,Ma L,Pei G

更新日期：1997-10-01 00:00:00

abstract：:To study the contribution of retinal and cortical afferents to the patterns of glutamate- and homocysteate-like immunoreactivities in dorsal lateral geniculate, combined retinal and cortical ablations were performed in rats. In controls, glutamate immunoreactivity was in terminal-like dots and neurons. Homocysteate im...

journal_title：Neuroscience research

authors： Grandes P,Mateos JM,Azkue J,Sarría R,Cuénod M,Streit P

更新日期：1997-04-01 00:00:00

abstract：:The role of GABA in medial preoptico-anterior hypothalamic area in the regulation of spontaneous sleep-wakefulness and rapid eye movement sleep was investigated in this study. Local microinjection of picrotoxin, a GABA-A antagonist, into this area increased quiet wakefulness but significantly reduced deep sleep and ra...

journal_title：Neuroscience research

authors： Ali M,Jha SK,Kaur S,Mallick BN

更新日期：1999-03-01 00:00:00

abstract：:The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...

journal_title：Neuroscience research

authors： Nakanishi S,Kuwajima G,Mikoshiba K

更新日期：1992-10-01 00:00:00

abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...

journal_title：Neuroscience research

authors： Im JY,Lee KW,Junn E,Mouradian MM

更新日期：2010-07-01 00:00:00

abstract：:Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...

journal_title：Neuroscience research

authors： Kanazawa I,Ogawa T,Kimura S,Munekata E

更新日期：1984-12-01 00:00:00

abstract：:Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

journal_title：Neuroscience research

authors： O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

更新日期：2010-02-01 00:00:00

abstract：:Recently the authors showed that a computational model of visual saliency could account for changes in gaze behavior of monkeys with damage in the primary visual cortex. Here we propose a neural prosthesis to restore eye gaze behavior by electrically stimulating the superior colliculus to drive visual attention. The s...

journal_title：Neuroscience research

authors： Yoshida M,Veale R

更新日期：2014-01-01 00:00:00

abstract：:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...

journal_title：Neuroscience research

authors： Abelaira HM,Réus GZ,Ribeiro KF,Steckert AV,Mina F,Rosa DV,Santana CV,Romano-Silva MA,Dal-Pizzol F,Quevedo J

更新日期：2013-04-01 00:00:00

abstract：:Hippocalcin is a recently identified Ca(2+)-binding protein with three EF-hand structures, dominantly expressed in the hippocampal pyramidal layer. The complete amino acid sequence of hippocalcin deduced from the cDNA is composed of 195 residues, has a calculated molecular mass of 22,574 daltons, and has a striking se...

journal_title：Neuroscience research

authors： Takamatsu K,Noguchi T

更新日期：1993-09-01 00:00:00

abstract：:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...

journal_title：Neuroscience research

authors： Furukawa K,Onodera H,Kogure K,Akaike N

更新日期：1993-02-01 00:00:00

abstract：:Glutamate receptor subtypes mediating excitatory synaptic neurotransmission in the cerebellar cortex are briefly reviewed from molecular biological, electrophysiological and pharmacological points of view. In particular, molecular biological findings of a novel family of AMPA-selective glutamate receptors are introduc...

journal_title：Neuroscience research

authors： Okamoto K,Sekiguchi M

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

journal_title：Neuroscience research

authors： Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

更新日期：2008-02-01 00:00:00