Myocardial nerve fibers are preserved in MPTP-treated mice, despite cardiac sympathetic dysfunction.

Abstract:

:Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Although binding assay showed a decreased density of norepinephrine transporter (NET) in the hearts of the mice, their histopathological alterations have not been demonstrated. In this study, we investigated hearts of MPTP-treated mice with immunohistochemical method and Western blot analyses. MPTP-treated mice showed significant decreases in the contents of cardiac noradrenaline and dopamine, suggesting the sympathetic dysfunction. Synaptophysin-, tyrosine hydroxylase- or NET-immunoreactive nerve fibers were abundant in the hearts of control mice and MPTP-treated mice, without apparent differences between the two groups. Western blot analyses also showed no difference in the amounts of these proteins. Myocardial nerve fibers were well preserved in MPTP-treated mice, despite apparent cardiac sympathetic dysfunction.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Amino T,Uchihara T,Tsunekawa H,Takahata K,Shimazu S,Mizusawa H,Orimo S

doi

10.1016/j.neures.2007.11.011

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

314-8

issue

3

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(07)01852-4

journal_volume

60

pub_type

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