Abstract：
:Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane capacitance, an indicator of the total cell surface area, was increased 3- and 1.5-fold by 10-day treatment with NGF and 8-Br-cAMP, respectively. At the same time, NGF increased the current density of both INa and ICa approximately 25 and 2.5 times greater than in their respective controls. 8-Br-cAMP also increased both current densities; the effect on the INa was one-third less than that of NGF, while the effect on the ICa was similar to that of NGF. It was concluded that NGF has strong and moderate effects, respectively, on the expression of voltage-dependent Na+ and Ca2+ channels. 8-Br-cAMP mimicked the effect of NGF especially in Ca2+ channel expression.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Furukawa K,Onodera H,Kogure K,Akaike Ndoi
10.1016/0168-0102(93)90081-zsubject
Has Abstractpub_date
1993-02-01 00:00:00pages
143-7issue
2eissn
0168-0102issn
1872-8111pii
0168-0102(93)90081-Zjournal_volume
16pub_type
杂志文章abstract：:Slow disjunctive eye movement similar to ocular convergence was evoked by microstimulation in parts of the lateral suprasylvian area (LSA) in alert cats. A tungsten-in-glass microelectrode was used for stimulation, and eye movement was monitored using the magnetic search coil method. The velocity-versus-amplitude rela...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90120-n
更新日期：1991-10-01 00:00:00
abstract：:A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...
journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00100-x
更新日期：1998-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
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更新日期：2003-08-01 00:00:00
abstract：:Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...
journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1995-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90033-3
更新日期：1989-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：1991-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1989-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0168-0102(93)90057-w
更新日期：1993-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90047-7
更新日期：1994-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.002
更新日期：2018-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1996-12-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2009-08-01 00:00:00
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更新日期：2013-03-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2003-09-01 00:00:00
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更新日期：1997-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00062-5
更新日期：1998-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2011-04-01 00:00:00
abstract：:Opiates have been used extensively in the treatment of pain but with the severe side effect of addiction, which is believed to be related to opiates' direct (primary) or indirect (secondary) neurotoxicity. In this study, the effects of opioids on cell growth and apoptosis have been examined in human neuroblastoma cell...
journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1997-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90023-r
更新日期：1991-01-01 00:00:00
abstract：:Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2011.11.002
更新日期：2012-02-01 00:00:00
