Internal structure of the rat subiculum characterized by diverse immunoreactivities and septotemporal differences.

Abstract:

:The subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum comprised one region, whereas the temporal subiculum consisted of two subregions, the distal subiculum (Sub1) and proximal subiculum (Sub2). The Sub2 contained four layers: (1) molecular layer, (2) superficial cell layer containing three types of pyramidal neurons immunolabeled for either nitric oxide synthase, Purkinje cell protein 4 (PCP4), or calbindin, (3) middle cell layer where boutons labeled for zinc transporter 3 and those for vesicular glutamate transporter 2 accumulated in the proximal and distal part of the Sub2, respectively, and (4) deep cell layer containing PCP4-positive pyramidal cells, apical dendrites of which showed a characteristic bundling pattern. These features were not observed in either the Sub1 or septal subiculum. There were clear species differences between rats and mice in labeling patterns of pyramidal cells. Morphological differences along the septotemporal axis might be the basis of the functional diversity of the subiculum, such as spatial memory and emotional memory processed at different septotemporal levels.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Ishihara Y,Fukuda T,Sato F

doi

10.1016/j.neures.2019.02.001

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

17-28

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(18)30538-8

journal_volume

150

pub_type

杂志文章
  • Non-NMDA and NMDA receptors are involved in suprathreshold excitation of network of frog tectal neurons by a single retinal ganglion cell.

    abstract::NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.12.014

    authors: Kuras A,Baginskas A,Batuleviciene V

    更新日期:2006-04-01 00:00:00

  • Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences.

    abstract::Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.10.006

    authors: Singh S,Kumar P

    更新日期:2018-08-01 00:00:00

  • Input-output organization of the rostral part of the dorsal premotor cortex, with special reference to its corticostriatal projection.

    abstract::Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.09.006

    authors: Tachibana Y,Nambu A,Hatanaka N,Miyachi S,Takada M

    更新日期:2004-01-01 00:00:00

  • Impairment of active avoidance produced after destruction of pedunculopontine nucleus areas in the rat.

    abstract::Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(89)90024-2

    authors: Fujimoto K,Yoshida M,Ikeguchi K,Niijima K

    更新日期:1989-04-01 00:00:00

  • mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study.

    abstract::By combining biochemical, molecular and immunohistochemical approaches, we have investigated the presence of metabotropic glutamate receptors (mGluRs) belonging to the subtype 5 in rat and human spinal cords and the developmental changes in their expression. A polyclonal antibody raised against the carboxy-terminal po...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)01175-9

    authors: Valerio A,Rizzonelli P,Paterlini M,Moretto G,Knöpfel T,Kuhn R,Memo M,Spano P

    更新日期:1997-05-01 00:00:00

  • Alteration of a motor learning rule under mirror-reversal transformation does not depend on the amplitude of visual error.

    abstract::Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.12.010

    authors: Kasuga S,Kurata M,Liu M,Ushiba J

    更新日期:2015-05-01 00:00:00

  • Correlation between anti-ubiquitin immunoreactivity and region-specific neuronal death in N-methyl-D-aspartate-treated rat hippocampal organotypic cultures.

    abstract::Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(95)00911-c

    authors: Okada M,Sakaguchi T,Kawasaki K

    更新日期:1995-07-01 00:00:00

  • Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats.

    abstract::Cytokines have been implicated in the etiology or pathology of various psychiatric diseases of developmental origin such as autism and schizophrenia. Leukemia inhibitory factor (LIF) is induced by a variety of brain insults and known to have many influences on mature and immature nervous system. Here, we assessed the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.12.001

    authors: Watanabe Y,Hashimoto S,Kakita A,Takahashi H,Ko J,Mizuno M,Someya T,Patterson PH,Nawa H

    更新日期:2004-03-01 00:00:00

  • GABAergic neurons in inferior colliculus of the GAD67-GFP knock-in mouse: electrophysiological and morphological properties.

    abstract::Utilizing slice preparations of GAD67-GFP knock-in mouse, in which GABAergic neurons are specifically labeled with GFP fluorescence, we studied electrophysiological characteristics of GABAergic neurons of IC by whole-cell patch clamp-recording combined with biocytin-intracellular-staining techniques. GABAergic neurons...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.12.019

    authors: Ono M,Yanagawa Y,Koyano K

    更新日期:2005-04-01 00:00:00

  • Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.

    abstract::Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2018.05.007

    authors: Murao N,Matsubara S,Matsuda T,Noguchi H,Mutoh T,Mutoh M,Koseki H,Namihira M,Nakashima K

    更新日期:2019-06-01 00:00:00

  • Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging.

    abstract::The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. H...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2008.10.006

    authors: Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I

    更新日期:2009-01-01 00:00:00

  • The magnitude of long-term potentiation of field potentials induced monosynaptically in region CA3 of guinea pig hippocampus.

    abstract::The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(86)90060-x

    authors: Higashima M,Yamamoto C

    更新日期:1986-09-01 00:00:00

  • Depending on the mode of application morphine enhances or depresses somatocardiac sympathetic A- and C-reflexes in anesthetized rats.

    abstract::The effects of morphine on the reflex discharges in sympathetic efferents recorded from branches of the inferior cardiac nerve (ICN) were studied in rats anesthetized with alpha-chloralose and urethane. Somatocardiac sympathetic A- and C-reflexes were elicited by single shock electrical stimulation of myelinated (A) a...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(92)90049-i

    authors: Adachi T,Sato A,Sato Y,Schmidt RF

    更新日期:1992-12-01 00:00:00

  • Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells.

    abstract::Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00036-6

    authors: Salimi K,Moser K,Zassler B,Reindl M,Embacher N,Schermer C,Weis C,Marksteiner J,Sawada M,Humpel C

    更新日期:2002-07-01 00:00:00

  • Quantitative and temporal relationship between local cerebral blood flow and neuronal activation induced by somatosensory stimulation in rats.

    abstract::In many studies on functional neuroimaging, change in local cerebral blood flow induced by sensory stimulation (evoked LCBF) is used as a marker for change in cortical neuronal activity, although a full description of the relationship between the evoked LCBF and neuronal activity has not been given. The purpose of thi...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00236-x

    authors: Matsuura T,Kanno I

    更新日期:2001-07-01 00:00:00

  • Super-oxide anion production and antioxidant enzymatic activities associated with the executive functions in peripheral blood mononuclear cells of healthy adult samples.

    abstract::Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Bl...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.11.007

    authors: Pesce M,Rizzuto A,La Fratta I,Tatangelo R,Campagna G,Iannasso M,Ferrone A,Franceschelli S,Speranza L,Patruno A,De Lutiis MA,Felaco M,Grilli A

    更新日期:2016-05-01 00:00:00

  • Bilateral intrahippocampal NAC61-95 effects on behavior and moderation with L-NAME treatment.

    abstract::Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.11.002

    authors: O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

    更新日期:2010-02-01 00:00:00

  • Area dependent expression of ZNF312 in human fetal cerebral cortex.

    abstract::The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.05.007

    authors: Zhu H,Yang Y,Gao J,Tao H,Qu C,Qu J,Chen J

    更新日期:2010-09-01 00:00:00

  • The role of the external nucleus of the inferior colliculus in the construction of the superior collicular auditory space map in the guinea-pig.

    abstract::In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(96)01060-7

    authors: Thornton SK,Withington DJ

    更新日期:1996-07-01 00:00:00

  • Auditory neuroscience in fruit flies.

    abstract::Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2013.04.003

    authors: Kamikouchi A

    更新日期:2013-07-01 00:00:00

  • Phasic nicotinic potentiation of frog retinotectal transmission enhances intrinsic activity of tectum column.

    abstract::It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.07.002

    authors: Baginskas A,Kuraite V,Kuras A

    更新日期:2012-09-01 00:00:00

  • Effects of neuromuscular blocking agents on central respiratory control in the isolated brainstem-spinal cord of neonatal rat.

    abstract::Although neuromuscular blocking agents (NMBAs) function as muscular nicotinic acetylcholine receptor (nAChR) antagonists, several studies have shown that they block neuronal nAChRs as well, which led us to hypothesize that these agents can affect neuronal nAChRs expressed in respiratory centers. To test this hypothesi...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(03)00213-x

    authors: Sakuraba S,Kuwana S,Ochiai R,Okada Y,Kashiwagi M,Hatori E,Takeda J

    更新日期:2003-11-01 00:00:00

  • Developmental changes of K(+)-dependent para-nitrophenylphosphatase (Na(+)-K(+)-ATPase) distribution in the synaptic regions in the cerebral cortex of rats.

    abstract::Using Mayahara's method, the distribution of K(+)-dependent p-nitrophenylphosphatase activity was examined electron microscopically in the synaptic regions of the cerebral cortex of 10, 15 and 60-day-old Wistar rats. The enzyme achieved gradually its characteristic localization and uniform distribution. The main devel...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(95)01004-1

    authors: Dolapchieva S

    更新日期:1996-02-01 00:00:00

  • Development of the rat respiratory neuron network during the late fetal period.

    abstract::We studied developmental changes in respiratory-like C4 activity and respiratory-related neurons in the ventrolateral medulla (VLM) of brainstem-spinal cord preparations from rat fetuses after embryonic day 16 (E16). In addition to respiratory nerve activity, non-respiratory activity was recorded from the C4 ventral r...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00322-4

    authors: Onimaru H,Homma I

    更新日期:2002-03-01 00:00:00

  • Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood.

    abstract::Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachia...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.10.007

    authors: Ebisawa T,Numazawa K,Shimada H,Izutsu H,Sasaki T,Kato N,Tokunaga K,Mori A,Honma K,Honma S,Shibata S

    更新日期:2010-02-01 00:00:00

  • Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus.

    abstract::The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.09.007

    authors: Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

    更新日期:2006-12-01 00:00:00

  • Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat central nervous system.

    abstract::Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(84)90009-9

    authors: Kanazawa I,Ogawa T,Kimura S,Munekata E

    更新日期:1984-12-01 00:00:00

  • Different perceptual sensitivities for Chernoff's face between children and adults.

    abstract::The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2007.10.009

    authors: Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

    更新日期:2008-02-01 00:00:00

  • Connexin mRNA expression in single dopaminergic neurons of substantia nigra pars compacta.

    abstract::Dopaminergic neurons of the substantia nigra pars compacta play a major role in goal-directed behavior and reinforcement learning. The study of their local interactions has revealed that they are connected by electrical synapses. Connexins, the molecular substrate of electrical synapses, constitute a multigenic family...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.08.013

    authors: Vandecasteele M,Glowinski J,Venance L

    更新日期:2006-12-01 00:00:00

  • Brain development and multiple molecular species of proteoglycan.

    abstract::The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/0168-0102(94)90088-4

    authors: Oohira A,Katoh-Semba R,Watanabe E,Matsui F

    更新日期:1994-09-01 00:00:00