Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging.


:The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. However, the intensities of the (19)F NMR signals were dramatically reduced in mouse brain lysates. Our results indicate that the inhibitory effect of brain tissue on the (19)F NMR signals from these probes can be attributed to the hydrophobicity of the tissue. These results highlight the importance of using hydrophilic (19)F-MRI agents to avoid the inhibitory effects of brain tissues on (19)F NMR signals.


Neurosci Res


Neuroscience research


Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I




Has Abstract


2009-01-01 00:00:00














  • Effects of unexpected perturbations on trajectories and EMG patterns of rapid wrist flexion movements in humans.

    abstract::To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hayashi R,Becker WJ,Lee RG

    更新日期:1990-06-01 00:00:00

  • Event-related brain potentials to unfamiliar faces in explicit and implicit memory tasks.

    abstract::The purpose of this study was to investigate electrophysiological correlates related to the recognition of repeated faces in the intact human by means of event-related brain potentials (ERPs). A group of young healthy adults performed a continuous face recognition task, in which 240 unfamiliar faces were flashed upon ...

    journal_title:Neuroscience research

    pub_type: 临床试验,杂志文章


    authors: Münte TF,Brack M,Grootheer O,Wieringa BM,Matzke M,Johannes S

    更新日期:1997-07-01 00:00:00

  • Correlation between anti-ubiquitin immunoreactivity and region-specific neuronal death in N-methyl-D-aspartate-treated rat hippocampal organotypic cultures.

    abstract::Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Okada M,Sakaguchi T,Kawasaki K

    更新日期:1995-07-01 00:00:00

  • Mossy fibers in the cerebellar hemisphere show delay activity in a delayed response task.

    abstract::To examine whether mossy fibers (MFs) in the cerebellar hemisphere show delay activity, we recorded MF activity during a wrist movement task with a random instructed delay period in two monkeys. Among 155 task-related MFs, 70 MFs (45%) demonstrated significant delay activity. Those MFs were widely distributed in the c...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ishikawa T,Tomatsu S,Tsunoda Y,Hoffman DS,Kakei S

    更新日期:2014-10-01 00:00:00

  • Variety of morphological and electrophysiological properties of area postrema neurons in adult rat brain slices.

    abstract::Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Funahashi M,Mitoh Y,Akaike T,Matsuo R

    更新日期:2006-01-01 00:00:00

  • Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

    abstract::In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Takahashi H,Takada Y,Urano T,Takada A

    更新日期:2001-05-01 00:00:00

  • Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.

    abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

    更新日期:2010-04-01 00:00:00

  • Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft).

    abstract::The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Noyama K,Maekawa S

    更新日期:2003-02-01 00:00:00

  • The role of the external nucleus of the inferior colliculus in the construction of the superior collicular auditory space map in the guinea-pig.

    abstract::In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Thornton SK,Withington DJ

    更新日期:1996-07-01 00:00:00

  • The calming effect of a maternal breast milk odor on the human newborn infant.

    abstract::We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

    更新日期:2009-01-01 00:00:00

  • The effects of D-alpha-aminoadipic acid on long-term potentiation in the hippocampus of the rat in vitro.

    abstract::Many studies on long-term potentiation (LTP) in hippocampal region CA1 focus on receptor-mediated events that are often presumed to be linked to postsynaptic processes. Whereas it is now well-known that LTP consists of multiple components involving increases in postsynaptic responsiveness as well as enhanced presynapt...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hicks TP,Ito KI

    更新日期:1996-01-01 00:00:00

  • Time-dependent expression of Na and Ca channels in PC12 cells by nerve growth factor and cAMP.

    abstract::Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Furukawa K,Onodera H,Kogure K,Akaike N

    更新日期:1993-02-01 00:00:00

  • Effect of different spinal cord lesions on visually guided switching of target-reaching in cats.

    abstract::It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Alstermark B,Górska T,Lundberg A,Pettersson LG,Walkowska M

    更新日期:1987-10-01 00:00:00

  • An electrochemical microprobe for detecting nitric oxide release in brain tissue.

    abstract::To detect the release of nitric oxide (NO) in brain tissue, an electrochemical microprobe was developed. The output current of the probe correlated linearly with the NO concentration at the tip, and the sensitivity of the probe was between 3.5 and 106 pA per 1 microM change in NO concentration. This probe showed no se...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Shibuki K

    更新日期:1990-09-01 00:00:00

  • Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.

    abstract::Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

    更新日期:2006-12-01 00:00:00

  • Acute ethanol administration transiently decreases [3H]-DAMGO binding to mu opioid receptors in the rat substantia nigra pars reticulata but not in the caudate-putamen.

    abstract::Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Méndez M,Leriche M,Carlos Calva J

    更新日期:2003-10-01 00:00:00

  • Motor deficits and hyperactivity in Dyt1 knockdown mice.

    abstract::The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Dang MT,Yokoi F,Pence MA,Li Y

    更新日期:2006-12-01 00:00:00

  • Effects of the gravitational vertical on the visual perception of reversible figures.

    abstract::We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Yamamoto S,Yamamoto M

    更新日期:2006-06-01 00:00:00

  • Voltage-gated ionic currents and their roles in timing coding in auditory neurons of the nucleus magnocellularis of the chick.

    abstract::Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Koyano K,Funabiki K,Ohmori H

    更新日期:1996-09-01 00:00:00

  • Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone.

    abstract::The subgranular zone (SGZ) in the dentate gyrus contains radial astrocytes, known as Type-1 or Type-B cells, which generate neuroblasts (Type-2 cells or Type-D cells) that give rise to granular neurons. Stress increases glucocorticoid levels that target SGZ and modify the proliferation and apoptosis of hippocampal cel...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Gonzalez-Perez O,Chavez-Casillas O,Jauregui-Huerta F,Lopez-Virgen V,Guzman-Muniz J,Moy-Lopez N,Gonzalez-Castaneda RE,Luquin S

    更新日期:2011-07-01 00:00:00

  • Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide.

    abstract::Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Melo JB,Agostinho P,Oliveira CR

    更新日期:2003-01-01 00:00:00

  • No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia.

    abstract::This study was to aim at investigating the potential interaction for the serotonin receptor gene (5-HTR) 2A and serotonin transporter gene (5-HTTLPR) polymorphisms in the development of schizophrenia, as well as the interaction of the two polymorphisms in relation with symptomatology, family history, age of onset and ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Pae CU,Artioli P,Serretti A,Kim TS,Kim JJ,Lee CU,Lee SJ,Lee C,Paik IH

    更新日期:2005-06-01 00:00:00

  • Multibarreled glass-coated tungsten microelectrode for both neuronal activity recording and iontophoresis in monkeys.

    abstract::A multibarreled glass-coated tungsten microelectrode suitable for single-unit recording and iontophoresis in chronically behaving animals is described. The microelectrode was stiff enough to pass through the dura matter of behaving monkeys, and can be applied as a microiontophoretic electrode. The electrode is easy to...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Li BM,Mei ZT,Kubota K

    更新日期:1990-07-01 00:00:00

  • Brain development and multiple molecular species of proteoglycan.

    abstract::The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Oohira A,Katoh-Semba R,Watanabe E,Matsui F

    更新日期:1994-09-01 00:00:00

  • Early event-related potentials indicate context-specific target processing for eye and hand motor systems.

    abstract::Concurrent eye and hand movements toward a common visual target require different motor programs based on identical visual input. We used event-related brain potentials (ERP) to determine if and when the processing of the visual target differs for the two motor systems. The N2, an index for target evaluation, was more...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Wehrspaun CC,Pfabigan DM,Sailer U

    更新日期:2013-09-01 00:00:00

  • Phasic nicotinic potentiation of frog retinotectal transmission enhances intrinsic activity of tectum column.

    abstract::It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Baginskas A,Kuraite V,Kuras A

    更新日期:2012-09-01 00:00:00

  • Adaptive changes in human smooth pursuit eye movement.

    abstract::Adaptive changes in initial eye velocity of pursuit eye movement were examined in nine normal subjects using a target that moved in a multiple ramp fashion. Significant changes in initial eye velocity occurred rapidly after training in six of the subjects. The magnitude and direction of the induced changes were a func...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Fukushima K,Tanaka M,Suzuki Y,Fukushima J,Yoshida T

    更新日期:1996-08-01 00:00:00

  • Brain-spinal cord neural circuits controlling male sexual function and behavior.

    abstract::Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Sakamoto H

    更新日期:2012-02-01 00:00:00

  • Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain.

    abstract::We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects of NSE on cultured mesencephalic and s...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hattori T,Takei N,Mizuno Y,Kato K,Kohsaka S

    更新日期:1995-01-01 00:00:00

  • The use of fish models to study human neurological disorders.

    abstract::Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Matsui H

    更新日期:2017-07-01 00:00:00