Abstract：
:Cytokines have been implicated in the etiology or pathology of various psychiatric diseases of developmental origin such as autism and schizophrenia. Leukemia inhibitory factor (LIF) is induced by a variety of brain insults and known to have many influences on mature and immature nervous system. Here, we assessed the neurobehavioral and pathological consequences of peripheral administration of LIF in newborn rats. Subcutaneous LIF injection induced STAT3 phosphorylation in many brain regions and increased glial fibrillary acidic protein (GFAP) immunoreactivity in the neocortex, suggesting that LIF had direct effects in the central nervous system. The LIF-treated rats displayed decreased motor activity during juvenile stages, and developed abnormal prepulse inhibition in the acoustic startle test during and after adolescence. They displayed normal learning ability in active avoidance test, however. Brain neuronal structures and startle responses were grossly normal, except for the cortical astrogliosis during neonatal LIF administration. These results indicate that LIF induction in the periphery of the infant has a significant, but discrete impact on neurobehavioral development.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Watanabe Y,Hashimoto S,Kakita A,Takahashi H,Ko J,Mizuno M,Someya T,Patterson PH,Nawa Hdoi
10.1016/j.neures.2003.12.001subject
Has Abstractpub_date
2004-03-01 00:00:00pages
345-53issue
3eissn
0168-0102issn
1872-8111pii
S0168010203003377journal_volume
48pub_type
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