Abstract:
:Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were not affected. In the lesioned rats, choline acetyltransferase activity in the medial thalamus and substantia nigra decreased, but not in the lateral thalamus, hippocampus, or cerebral cortex. These findings suggest that the cholinergic pedunculopontine-medial thalamus projection plays an important role in memory acquisition in the rat.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Fujimoto K,Yoshida M,Ikeguchi K,Niijima Kdoi
10.1016/0168-0102(89)90024-2subject
Has Abstractpub_date
1989-04-01 00:00:00pages
321-8issue
4eissn
0168-0102issn
1872-8111pii
0168-0102(89)90024-2journal_volume
6pub_type
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