Abstract:
:Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-colony stimulating factor (GM-CSF). Endogenous GDNF and its receptor, GFRalpha-1, were detected in GMIR1 cells by ELISA and immunohistochemistry/Western blot, respectively. Recombinant GDNF strongly enhanced GMIR1 cell numbers and BrdU-incorporation, an effect inhibited by GDNF blocking antibodies. Inhibition of cAMP/cGMP dependent protein kinase enhanced the GDNF-induced GMIR1 cell number. The results suggest that GDNF has synergistic survival promoting effects on microglia potentially via autocrine mechanisms.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Salimi K,Moser K,Zassler B,Reindl M,Embacher N,Schermer C,Weis C,Marksteiner J,Sawada M,Humpel Cdoi
10.1016/s0168-0102(02)00036-6subject
Has Abstractpub_date
2002-07-01 00:00:00pages
221-9issue
3eissn
0168-0102issn
1872-8111pii
S0168010202000366journal_volume
43pub_type
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