Developmental changes of K(+)-dependent para-nitrophenylphosphatase (Na(+)-K(+)-ATPase) distribution in the synaptic regions in the cerebral cortex of rats.

abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...

journal_title：Neuroscience research

authors： Hirasawa M,Cho A,Sreenath T,Sauer B,Julien JP,Kulkarni AB

更新日期：2001-06-01 00:00:00

abstract：:In order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (LH) concentrations were measured in female rats after making lesions in this nucleus (DRL) and/or treatment with 5-hydroxytryptamine (5-HT) receptor...

journal_title：Neuroscience research

authors： Maekawa F,Tsukahara S,Tsukamura H,Maeda KI,Yamanouchi K

更新日期：1999-12-30 00:00:00

abstract：:Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarif...

journal_title：Neuroscience research

authors： Dai H,Kaneko K,Kato H,Fujii S,Jing Y,Xu A,Sakurai E,Kato M,Okamura N,Kuramasu A,Yanai K

更新日期：2007-02-01 00:00:00

abstract：:Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...

journal_title：Neuroscience research

authors： Matsui H

更新日期：2017-07-01 00:00:00

abstract：:We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those o...

journal_title：Neuroscience research

authors： Shiba Y,Mori F,Yamada J,Migita K,Nikaido Y,Wakabayashi K,Kaneko S,Okada M,Hirose S,Ueno S

更新日期：2015-11-01 00:00:00

abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...

journal_title：Neuroscience research

authors： Kim JE,Kwak SE,Kim DS,Won MH,Choi HC,Song HK,Kim YI,Kang TC

更新日期：2007-03-01 00:00:00

abstract：:Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured using paired-pulse transcranial magnetic stimulation (interstimulus interval=2ms) in samples of young and healthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard test and two isometr...

journal_title：Neuroscience research

authors： Marneweck M,Loftus A,Hammond G

更新日期：2011-08-01 00:00:00

abstract：:It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...

journal_title：Neuroscience research

authors： Alstermark B,Górska T,Lundberg A,Pettersson LG,Walkowska M

更新日期：1987-10-01 00:00:00

abstract：:Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...

journal_title：Neuroscience research

authors： Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

更新日期：2019-07-01 00:00:00

abstract：:We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

journal_title：Neuroscience research

authors： Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

更新日期：2009-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...

journal_title：Neuroscience research

authors： Beier M,Franke A,Paunel-Görgülü AN,Scheerer N,Dünker N

更新日期：2006-10-01 00:00:00

abstract：:The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, ...

journal_title：Neuroscience research

authors： Yamakado M

更新日期：1995-11-01 00:00:00

abstract：:L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...

journal_title：Neuroscience research

authors： Tanaka K

更新日期：2000-05-01 00:00:00

abstract：:To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the...

journal_title：Neuroscience research

authors： Kasuya J,Kaas G,Kitamoto T

更新日期：2009-08-01 00:00:00

abstract：:The aim of the present study was to test the possibility that the catecholaminergic projectional pathway from the vagus nerve to the medullary visceral zone (MVZ) thence to the paraventricular nucleus of hypothalamus (PVN) was involved in the cytokine-to-brain communication. A triple labeling method in which WGA-HRP r...

journal_title：Neuroscience research

authors： Yang ZJ,Rao ZR,Ju G

更新日期：2000-11-01 00:00:00

abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...

journal_title：Neuroscience research

authors： Nakamura TJ,Shinohara K,Funabashi T,Mitsushima D,Kimura F

更新日期：2001-09-01 00:00:00

abstract：:To examine whether mossy fibers (MFs) in the cerebellar hemisphere show delay activity, we recorded MF activity during a wrist movement task with a random instructed delay period in two monkeys. Among 155 task-related MFs, 70 MFs (45%) demonstrated significant delay activity. Those MFs were widely distributed in the c...

journal_title：Neuroscience research

authors： Ishikawa T,Tomatsu S,Tsunoda Y,Hoffman DS,Kakei S

更新日期：2014-10-01 00:00:00

abstract：:Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...

journal_title：Neuroscience research

authors： Salimi Z,Khajehpour L,Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2020-09-01 00:00:00

abstract：:To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

journal_title：Neuroscience research

authors： Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

更新日期：2005-05-01 00:00:00

abstract：:T-type Ca2+ channel-dependent long-term potentiation (LTP) occurs predominantly during the critical period of ocular dominance plasticity in rat and cat visual cortex. Noradrenaline and serotonin are known to facilitate ocular dominance plasticity. In this study using rat visual cortical slices, we tested whether this...

journal_title：Neuroscience research

authors： Inaba M,Maruyama T,Yoshimura Y,Hosoi H,Komatsu Y

更新日期：2009-06-01 00:00:00

abstract：:The cranial nerves and the brain fiber systems of the medaka (Oryzias latipes) fry are revealed by a whole-mount staining method. Newly hatched fry of an albino strain of the medaka were fixed, partially digested with trypsin, treated in 1% Triton X-100, and finally immunohistochemically stained using anti-neurofilame...

journal_title：Neuroscience research

authors： Ishikawa Y,Hyodo-Taguchi Y

更新日期：1994-06-01 00:00:00

abstract：:Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using funct...

journal_title：Neuroscience research

authors： Ohnishi T,Matsuda H,Hirakata M,Ugawa Y

更新日期：2006-08-01 00:00:00

abstract：:Using techniques of combining intracellular recording and intracellular staining with biocytin, 19 neurons have been sampled within or close to the CA1 pyramidal cell layer in hippocampal slices of the rat. All of these cells were physiologically characterized as non-pyramidal or interneurons based on their action pot...

journal_title：Neuroscience research

authors： Han ZS

更新日期：1996-05-01 00:00:00

abstract：:We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...

journal_title：Neuroscience research

authors： Wakusawa K,Sugiura M,Sassa Y,Jeong H,Yomogida Y,Horie K,Sato S,Yokoyama H,Kure S,Takei N,Mori N,Kawashima R

更新日期：2015-01-01 00:00:00

abstract：:Narcolepsy is a chronic sleep disorder marked by excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Since the discovery of sleep onset REM periods (SOREMPs) in narcoleptic patients, narcolepsy has often been regarded as a disorder of REM sleep generation: REM sleep intrudes in act...

journal_title：Neuroscience research

authors： Nishino S,Riehl J,Hong J,Kwan M,Reid M,Mignot E

更新日期：2000-12-01 00:00:00

abstract：:Pseudorabies virus (PrV) as a neuronal tracer was microinjected into the concave surface of the puppy's left pinna to establish the morphological basis of somato-visceral linkage. The virus infected neurons were detected by FITC conjugated with polyclonal swine anti-PrV serum. Labelled neurons were localized in: (1) t...

journal_title：Neuroscience research

authors： Chien CH,Shieh JY,Liao MH,Ling EA,Wen CY

更新日期：1998-02-01 00:00:00

abstract：:Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for the maternal immune activation background in patients with neurodevelopmental disorders h...

journal_title：Neuroscience research

authors： Oh-Nishi A,Koga K,Maeda T,Suhara T

更新日期：2016-12-01 00:00:00

abstract：:Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...

journal_title：Neuroscience research

authors： Akagi H,Hirai K,Hishinuma F

更新日期：1991-06-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

journal_title：Neuroscience research

authors： Ishihara T,Orikasa C,Araki T,Sakuma Y

更新日期：2002-06-01 00:00:00

abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...

journal_title：Neuroscience research

authors： Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres A

更新日期：2008-07-01 00:00:00