Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor.

abstract：:Confocal laser scanning microscopy (CLSM) was used to record spatial and dynamic changes in the intracellular Ca2+ [(Ca2+]i) of bullfrog sympathetic ganglion cells in excised tissue or in culture. A CLSM utilizing Ar ion laser (488 nm) and recording fluo-3 fluorescence yielded the sliced image of ganglion cells, while...

journal_title：Neuroscience research

authors： Kuba K,Hua SY,Nohmi M

更新日期：1991-05-01 00:00:00

abstract：:Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...

journal_title：Neuroscience research

authors： Motegi Y,Sato M,Horiguchi K,Ohkura M,Gengyo-Ando K,Ikegaya Y,Fusamae Y,Hongo Y,Suzuki M,Ogawa K,Takaki M,Nakai J

更新日期：2020-02-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between the increase in local cerebral blood flow during neuronal activation (evoked LCBF) and the baseline flow level. We measured the hemodynamics in alpha-chloralose-anesthetized rats using laser-Doppler flowmetry during somatosensory stimulation under the...

journal_title：Neuroscience research

authors： Matsuura T,Fujita H,Kashikura K,Kanno I

更新日期：2000-12-01 00:00:00

abstract：:The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...

journal_title：Neuroscience research

authors： Dang MT,Yokoi F,Pence MA,Li Y

更新日期：2006-12-01 00:00:00

abstract：:Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...

journal_title：Neuroscience research

authors： Tachibana Y,Nambu A,Hatanaka N,Miyachi S,Takada M

更新日期：2004-01-01 00:00:00

abstract：:We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...

journal_title：Neuroscience research

authors： Yoshida T,Sakagami M,Katura T,Yamazaki K,Tanaka S,Iwamoto M,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:Cytokines have been implicated in the etiology or pathology of various psychiatric diseases of developmental origin such as autism and schizophrenia. Leukemia inhibitory factor (LIF) is induced by a variety of brain insults and known to have many influences on mature and immature nervous system. Here, we assessed the ...

journal_title：Neuroscience research

authors： Watanabe Y,Hashimoto S,Kakita A,Takahashi H,Ko J,Mizuno M,Someya T,Patterson PH,Nawa H

更新日期：2004-03-01 00:00:00

abstract：:The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

journal_title：Neuroscience research

authors： Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

更新日期：2011-04-01 00:00:00

abstract：:In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of anaesthetised rats, whilst simultaneously recording activity of sensory afferents on the adventitial surface of femoral arteries and veins. Bradykinin (0.9 nmol...

journal_title：Neuroscience research

authors： Smith PJ,McQueen DS

更新日期：2004-11-01 00:00:00

abstract：:A single-pulse TMS to the human motor cortex (M1) influences reaction time (RT). We may summarize from previous studies where different groups of subjects participated in various types of RT tasks that TMS above motor threshold (MT) delays RT, whereas TMS below MT shortens RT and that these RT changes depends on TMS t...

journal_title：Neuroscience research

authors： Hashimoto T,Inaba D,Matsumura M,Naito E

更新日期：2004-12-01 00:00:00

abstract：:To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...

journal_title：Neuroscience research

authors： Nguyen BT,Tran TD,Hoshiyama M,Inui K,Kakigi R

更新日期：2004-10-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...

journal_title：Neuroscience research

authors： Mijangos-Moreno S,Poot-Aké A,Guzmán K,Arankowsky-Sandoval G,Arias-Carrión O,Zaldívar-Rae J,Sarro-Ramírez A,Murillo-Rodríguez E

更新日期：2016-04-01 00:00:00

abstract：:Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...

journal_title：Neuroscience research

authors： Kobayashi Y,Matsuyama K,Mori S

更新日期：1994-07-01 00:00:00

abstract：:alpha-Mannosidosis is a lysosomal storage disease resulting from a deficiency of the enzyme alpha-D-mannosidase. A major feature of alpha-mannosidosis is progressive neurological decline, for which there is no safe and effective treatment available. We have a guinea pig model of alpha-mannosidosis that models the huma...

journal_title：Neuroscience research

authors： Robinson AJ,Meedeniya AC,Hemsley KM,Auclair D,Crawley AC,Hopwood JJ

更新日期：2005-10-01 00:00:00

abstract：:Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...

journal_title：Neuroscience research

authors： Parker I,Gundersen CB,Miledi R

更新日期：1985-08-01 00:00:00

abstract：:A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

journal_title：Neuroscience research

authors： Siwach P,Sengupta S,Parihar R,Ganesh S

更新日期：2011-08-01 00:00:00

abstract：:Long-term depression at parallel fiber-Purkinje cell synapses plays a principal role in learning in the cerebellum, which acts as a supervised learning machine. Recent experiments demonstrate various forms of synaptic plasticity at different sites within the cerebellum. In this article, we take into consideration syna...

journal_title：Neuroscience research

authors： Yamazaki T,Lennon W

更新日期：2019-11-01 00:00:00

abstract：:Projection fields in the striatum and claustrum from eye movement-evoking cerebral cortices (EMECs) in the cat were investigated using the WGA-HRP tracing method under electrophysiological guidance to place WGA-HRP in the appropriate sites. The EMECs in the frontal cortex, which are located in the medial wall under th...

journal_title：Neuroscience research

authors： Miyashita E,Tamai Y

更新日期：1990-08-01 00:00:00

abstract：:GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...

journal_title：Neuroscience research

authors： Fukuda T,Aika Y,Heizmann CW,Kosaka T

更新日期：1996-10-01 00:00:00

abstract：:Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...

journal_title：Neuroscience research

authors： Ito K,Sato A,Shimamura K,Swenson RS

更新日期：1984-04-01 00:00:00

abstract：:We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...

journal_title：Neuroscience research

authors： Numasawa T,Shiba K,Nakazawa K,Umezaki T

更新日期：2004-07-01 00:00:00

abstract：:We simulated brain lesions in mean diffusivity (MD) and fractional anisotropy (FA) images of healthy subjects to evaluate the performance of voxel-based analysis (VBA) with SPM2. We increased MD and decreased FA, simulating the most typical abnormalities in brain pathologies, in the superior longitudinal fasciculus (S...

journal_title：Neuroscience research

authors： Hiltunen J,Seppä M,Hari R

更新日期：2011-12-01 00:00:00

abstract：:Trans-2,4-dimethoxystibene (S(3)) is a synthetic stilbene. In this study, S(3) was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (Abeta(25-35)) both in vitro and in vivo. Protection by S(3) was studied at the in vivo level using a model of intracerebroventricul...

journal_title：Neuroscience research

authors： Ruan CJ,Zhang L,Chen DH,Li Z,Du GH,Sun L

更新日期：2010-07-01 00:00:00

abstract：:Intracellular pH (pH(i)) plays an important role in the regulation of central nervous system function. In the present study, we examined whether hydrogen sulfide (H(2)S), a recently recognized neuromodulator, regulates pH(i) in rat primary cultured glia cells. pH(i) was measured with a fluorescent sensitive dye, BCECF...

journal_title：Neuroscience research

authors： Lu M,Choo CH,Hu LF,Tan BH,Hu G,Bian JS

更新日期：2010-01-01 00:00:00

abstract：:To investigate the functional organization in the monkey inferotemporal cortex, which is the last exclusively visual area along the ventral visual cortical pathway, optical imaging based on intrinsic signals was carried out. We first conducted single-cell recordings with microelectrodes and determined the features cri...

journal_title：Neuroscience research

authors： Wang G,Tanifuji M,Tanaka K

更新日期：1998-09-01 00:00:00

abstract：:The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...

journal_title：Neuroscience research

authors： Oka T,Yokota S,Tsumori T,Niu JG,Yasui Y

更新日期：2012-10-01 00:00:00

abstract：:In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...

journal_title：Neuroscience research

authors： Thornton SK,Withington DJ

更新日期：1996-07-01 00:00:00

abstract：:Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted...

journal_title：Neuroscience research

authors： Tsuda S,Kee MZ,Cunha C,Kim J,Yan P,Loew LM,Augustine GJ

更新日期：2013-01-01 00:00:00

abstract：:Effective connectivity analysis has been widely applied to noninvasive recordings such as functional magnetic resonance imaging and electroencephalograms (EEGs). Previous studies have aimed to extract the causal relations between brain regions, but the validity of the derived connectivity has not yet been fully determ...

journal_title：Neuroscience research

authors： Ye S,Kitajo K,Kitano K

更新日期：2020-07-01 00:00:00

abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...

journal_title：Neuroscience research

authors： Kim DS,Yoo KY,Hwang IK,Jung JY,Won MH,Choi SY,Kwon OS,Seo JH,Kang TC

更新日期：2005-01-01 00:00:00