Abstract:
:Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. These currents are not abolished by removing external calcium, but are completely abolished after EGTA is injected into the oocytes to chelate intracellular calcium. A smooth current response to serotonin remained in EGTA-loaded oocytes, indicating that this response does not require intracellular calcium. In contrast to the oscillatory chloride currents, the chloride currents activated by GABA or glycine are not abolished by intracellular injection of EGTA. Thus, there appear to be two classes of chloride channels one of which requires intracellular calcium to open.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Parker I,Gundersen CB,Miledi Rdoi
10.1016/0168-0102(85)90021-5subject
Has Abstractpub_date
1985-08-01 00:00:00pages
491-6issue
6eissn
0168-0102issn
1872-8111pii
0168-0102(85)90021-5journal_volume
2pub_type
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