Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

abstract：:The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

journal_title：Neuroscience research

authors： Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

更新日期：2008-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...

journal_title：Neuroscience research

authors： Singh S,Kumar P

更新日期：2018-08-01 00:00:00

abstract：:The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

journal_title：Neuroscience research

authors： Oohira A,Katoh-Semba R,Watanabe E,Matsui F

更新日期：1994-09-01 00:00:00

abstract：:γ-Aminobutyric acid (GABA) generally induces hyperpolarization and inhibition in the adult brain, but causes depolarization (and can be excitatory) in the immature brain. Depolarizing GABA actions are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Additionally, the conversion of GABA respo...

journal_title：Neuroscience research

authors： Fukuda A

更新日期：2020-07-01 00:00:00

abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...

journal_title：Neuroscience research

authors： Kamiji NL,Yamamoto K,Hirasawa H,Yamada M,Usui S,Kurokawa M

更新日期：2012-04-01 00:00:00

abstract：:Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary mo...

journal_title：Neuroscience research

authors： Takarada Y,Nozaki D

更新日期：2014-08-01 00:00:00

abstract：:Electromyograms were recorded from the intralaryngeal muscles (the posterior cricoarytenoid (PCA) and thyroarytenoid (TA) muscles) and the ventilatory muscles (the diaphragm (DA) and abdominal (RA) muscle) during electrically induced vocalization in precollicular postmammillary decerebrate cats. Electrical stimulation...

journal_title：Neuroscience research

authors： Yamanaka Y,Sakamoto T,Wada K,Nakajima Y

更新日期：1993-06-01 00:00:00

abstract：:The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...

journal_title：Neuroscience research

authors： Sun S,Ohta A,Kuhara A,Nishikawa Y,Kage-Nakadai E

更新日期：2020-01-01 00:00:00

abstract：:Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...

journal_title：Neuroscience research

authors： Tachibana Y,Nambu A,Hatanaka N,Miyachi S,Takada M

更新日期：2004-01-01 00:00:00

abstract：:We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to ident...

journal_title：Neuroscience research

authors： Uchiyama Y,Toyoda H,Honda M,Yoshida H,Kochiyama T,Ebe K,Sadato N

更新日期：2008-07-01 00:00:00

abstract：:We investigated the distribution and colocalization pattern of the two corticosteroid receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the hippocampus and hypothalamus, the main target regions of corticosterone in the rat brain, using double immunofluorescence histochemistry in conjuncti...

journal_title：Neuroscience research

authors： Han F,Ozawa H,Matsuda K,Nishi M,Kawata M

更新日期：2005-04-01 00:00:00

abstract：:Some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. However it is not clear whether impairment of long-term potentiation depends on the oxidative stress evoked by sleep deprivation protocol. In this study we aimed to investigate the effects of...

journal_title：Neuroscience research

authors： Süer C,Dolu N,Artis AS,Sahin L,Yilmaz A,Cetin A

更新日期：2011-05-01 00:00:00

abstract：:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...

journal_title：Neuroscience research

authors： Monda M,Viggiano A,De Luca V

更新日期：2003-01-01 00:00:00

abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...

journal_title：Neuroscience research

authors： Liberini P,Valerio A,Moretto G,Rizzonelli P,Memo M,Rizzuto N,Spano PF

更新日期：1995-05-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

journal_title：Neuroscience research

authors： Ishihara T,Orikasa C,Araki T,Sakuma Y

更新日期：2002-06-01 00:00:00

abstract：:To detect the release of nitric oxide (NO) in brain tissue, an electrochemical microprobe was developed. The output current of the probe correlated linearly with the NO concentration at the tip, and the sensitivity of the probe was between 3.5 and 106 pA per 1 microM change in NO concentration. This probe showed no se...

journal_title：Neuroscience research

authors： Shibuki K

更新日期：1990-09-01 00:00:00

abstract：:A significant activity of [3H]glutamate binding was detected in homogenate particulate preparations obtained from the rat pituitary, in addition to central structures including the cerebral cortex. In contrast to the cerebral binding, the pituitary binding was significantly inhibited by Na+ ions. It was also found tha...

journal_title：Neuroscience research

authors： Yoneda Y,Ogita K

更新日期：1986-07-01 00:00:00

abstract：:Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

journal_title：Neuroscience research

authors： Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

更新日期：2016-11-01 00:00:00

abstract：:Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...

journal_title：Neuroscience research

authors： Arce VM,Devesa P,Devesa J

更新日期：2013-08-01 00:00:00

abstract：:Huntington's disease (HD) is caused due to expansion of CAG repeats in the gene huntingtin (Htt). Adaptor protein Grb2, involved in Ras-MAP kinase pathway, is a known interactor of Htt. Mutant Htt-Grb2 interaction reduces Ras-MAPK signaling in HD models. In normal cells Grb2 forms Grb2-Sos1-Gab1 complex through its N-...

journal_title：Neuroscience research

authors： Baksi S,Basu S,Mukhopadhyay D

更新日期：2014-10-01 00:00:00

abstract：:Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the n...

journal_title：Neuroscience research

authors： Candelario-Jalil E,Alvarez D,Merino N,León OS

更新日期：2003-10-01 00:00:00

abstract：:The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backpro...

journal_title：Neuroscience research

authors： Craig S,Commins S

更新日期：2005-10-01 00:00:00

abstract：:The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontop...

journal_title：Neuroscience research

authors： Lingenhöhl K,Knöpfel T,Olpe HR

更新日期：1993-12-01 00:00:00

abstract：:Communication in the central nervous system (CNS) occurs through initiation and propagation of action potentials at excitable domains along axons. Action potentials generated at the axon initial segment (AIS) are regenerated at nodes of Ranvier through the process of saltatory conduction. Proper formation and maintena...

journal_title：Neuroscience research

authors： Griggs RB,Yermakov LM,Susuki K

更新日期：2017-03-01 00:00:00

abstract：:We previously demonstrated that metabotropic glutamate receptor-subtype 1 knockout [mGluR1 (-/-)] mice showed ataxic gait, deficient long-term depression and impaired synapse elimination and these phenotypes were rescued by introduction of an mGluR1 transgene with Purkinje cell-specific promoter (mGluR1-rescue mice). ...

journal_title：Neuroscience research

authors： Nakao H,Nakao K,Kano M,Aiba A

更新日期：2007-04-01 00:00:00

abstract：:L-3,4-Dihydroxyphenylalanine (DOPA) has been believed to be a precursor of dopamine, and itself being an inert amino acid. Previously, we have proposed DOPA as a neurotransmitter candidate in the central nervous system (CNS). Recent findings have suggested DOPA as an endogenous agonist of a G-protein coupled receptor,...

journal_title：Neuroscience research

authors： Masukawa D,Nakamura F,Koga M,Kamiya M,Chen S,Yamashita N,Arai N,Goshima Y

更新日期：2014-11-01 00:00:00

abstract：:The critical flicker-fusion frequency (CFF), defined as the frequency at which a flickering light is indistinguishable from a continuous light, is a useful measure of visual temporal resolution. The mouse CFF has been studied by electrophysiological approaches such as recordings of the electroretinogram (ERG) and the ...

journal_title：Neuroscience research

authors： Nomura Y,Ikuta S,Yokota S,Mita J,Oikawa M,Matsushima H,Amano A,Shimonomura K,Seya Y,Koike C

更新日期：2019-11-01 00:00:00

abstract：:Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential l...

journal_title：Neuroscience research

authors： Fingelkurts AA,Fingelkurts AA,Kivisaari R,Autti T,Borisov S,Puuskari V,Jokela O,Kähkönen S

更新日期：2007-05-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...

journal_title：Neuroscience research

authors： Kim JH,Park M,Yang SY,Jeong BS,Yoo HJ,Kim JW,Chung JH,Kim SA

更新日期：2006-10-01 00:00:00

abstract：:NAP-22, a neuronal tissue-enriched acidic membrane protein, is a Ca(2+)-dependent calmodulin binding protein and has similar biochemical characteristics to GAP-43 (neuromodulin). Recent biochemical studies have demonstrated that NAP-22 localizes in the membrane raft domain with a cholesterol-dependent manner. Since th...

journal_title：Neuroscience research

authors： Kashihara M,Miyata S,Kumanogoh H,Funatsu N,Matsunaga W,Kiyohara T,Sokawa Y,Maekawa S

更新日期：2000-08-01 00:00:00