Abstract：
:Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In addition, the possibility that GH may play a role on brain repair after injury has been also envisaged, and a number of reports have shown that GH administration following injury confers neuroprotection and accelerates the recovery of some neural functions. In this review we have analyzed the state of the art of GH administration in several neural diseases. Though more studies are still necessary in order to completely understand the importance of GH in these processes, the promising results obtained so far, together with the absence of untoward effects during GH therapy, encourages the development of clinical assays in order to further support the use GH treatment in neural diseases in which neuroprotection and/or neuroregeneration are involved.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Arce VM,Devesa P,Devesa Jdoi
10.1016/j.neures.2013.03.014subject
Has Abstractpub_date
2013-08-01 00:00:00pages
179-86issue
4eissn
0168-0102issn
1872-8111pii
S0168-0102(13)00105-3journal_volume
76pub_type
杂志文章,评审abstract：:The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.09.005
更新日期：2006-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00064-4
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1992-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.07.006
更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0168-0102(96)01024-3
更新日期：1996-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.07.008
更新日期：2014-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00213-3
更新日期：2001-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00033-9
更新日期：1998-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2004-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2011.11.002
更新日期：2012-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01147-9
更新日期：1997-02-01 00:00:00
abstract：:In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.02.002
更新日期：2009-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.05.007
更新日期：2010-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.01.004
更新日期：2004-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:The effect of diazepam (DZP) on the GABA-induced macroscopic and microscopic Cl- current was investigated in isolated frog sensory neurons using both 'concentration-clamp' and patch-clamp techniques. At concentration range between 10(-9) and 10(-4) M, DZP itself evoked no response but potentiated time- and dose-depend...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90023-0
更新日期：1989-04-01 00:00:00
