Transforming growth factor beta mediates apoptosis in the ganglion cell layer during all programmed cell death periods of the developing murine retina.

abstract：:Tissue-type plasminogen activator (tPA) is a serine protease that converts the inactive precursor plasminogen to the active protease plasmin. In the central nervous system, tPA has been suggested to participate in plasticity, memory and the neuronal degeneration caused by excitotoxins, but its precise functions during...

journal_title：Neuroscience research

authors： Nagai N,Urano T,Endo A,Takahashi H,Takada Y,Takada A

更新日期：1999-02-01 00:00:00

abstract：:Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...

journal_title：Neuroscience research

authors： Krasnova IN,Hodges AB,Ladenheim B,Rhoades R,Phillip CG,Cesena A,Ivanova E,Hohmann CF,Cadet JL

更新日期：2009-10-01 00:00:00

abstract：:We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...

journal_title：Neuroscience research

authors： Numasawa T,Shiba K,Nakazawa K,Umezaki T

更新日期：2004-07-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

journal_title：Neuroscience research

authors： Ishihara T,Orikasa C,Araki T,Sakuma Y

更新日期：2002-06-01 00:00:00

abstract：:The pattern of distribution of cholinergic fibers was examined immunohistochemically in the cat superior colliculus by using a monoclonal antibody against choline acetyltransferase (ChAT). In the superficial layers, an obvious immunoreactive zone was found in the rostral two-thirds of the outer portion of the superfic...

journal_title：Neuroscience research

authors： Hashikawa T

更新日期：1989-06-01 00:00:00

abstract：:Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

journal_title：Neuroscience research

authors： Shirao T,Sekino Y

更新日期：2001-05-01 00:00:00

abstract：:Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...

journal_title：Neuroscience research

authors： Arce VM,Devesa P,Devesa J

更新日期：2013-08-01 00:00:00

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a recently identified member of the secretin/vasoactive intestinal polypeptide (VIP) family. There are at least two types of receptor for PACAP: type I (PACAPR), which specifically binds PACAP; and type II (VIP/PACAPR), which binds both PACAP and VIP. The l...

journal_title：Neuroscience research

authors： Shioda S,Shuto Y,Somogyvari-Vigh A,Legradi G,Onda H,Coy DH,Nakajo S,Arimura A

更新日期：1997-08-01 00:00:00

abstract：:A significant activity of [3H]glutamate binding was detected in homogenate particulate preparations obtained from the rat pituitary, in addition to central structures including the cerebral cortex. In contrast to the cerebral binding, the pituitary binding was significantly inhibited by Na+ ions. It was also found tha...

journal_title：Neuroscience research

authors： Yoneda Y,Ogita K

更新日期：1986-07-01 00:00:00

abstract：:The cranial nerves and the brain fiber systems of the medaka (Oryzias latipes) fry are revealed by a whole-mount staining method. Newly hatched fry of an albino strain of the medaka were fixed, partially digested with trypsin, treated in 1% Triton X-100, and finally immunohistochemically stained using anti-neurofilame...

journal_title：Neuroscience research

authors： Ishikawa Y,Hyodo-Taguchi Y

更新日期：1994-06-01 00:00:00

abstract：:Alcoholism is a psychiatric condition that develops through neuroadaptations in response to neuronal stresses caused by chronic ethanol intake. Neurons can adapt to ethanol-induced metabolic changes by activating cellular protective mechanisms, including autophagy. Here we show that expression of Ulk1, a gene critical...

journal_title：Neuroscience research

authors： Sumitomo A,Ueta K,Mauchi S,Hirai K,Horike K,Hikida T,Sakurai T,Sawa A,Tomoda T

更新日期：2017-04-01 00:00:00

abstract：:In an attempt to test the possibility that sino-aortic baroreceptors may mediate the previously reported stress response in hypothalamic magnocellular neurosecretory cell activity in rats, effects of deafferentation of sino-aortic baroreceptors on plasma levels of vasopressin and oxytocin after fear-related emotional ...

journal_title：Neuroscience research

authors： Onaka T,Yagi K

更新日期：1992-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...

journal_title：Neuroscience research

authors： Singh S,Kumar P

更新日期：2018-08-01 00:00:00

abstract：:Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...

journal_title：Neuroscience research

authors： Künzle H

更新日期：1997-06-01 00:00:00

abstract：:Forebrain heat shock protein 70 (HSP70) immunohistochemical reactivity was investigated in rats subjected to gamma knife irradiation focusing on the right caudate putamen nucleus. The forebrain sections of all experimental animals were processed with anti-HSP70 antiserum and then by avidin-biotin peroxidase complex im...

journal_title：Neuroscience research

authors： Rao ZR,Ge X,Qiou JY,Yang T,Duan L,Ju G

更新日期：2000-10-01 00:00:00

abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...

journal_title：Neuroscience research

authors： Djupsjöbacka M,Johansson H,Bergenheim M,Sjölander P

更新日期：1995-02-01 00:00:00

abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...

journal_title：Neuroscience research

authors： Kim DS,Yoo KY,Hwang IK,Jung JY,Won MH,Choi SY,Kwon OS,Seo JH,Kang TC

更新日期：2005-01-01 00:00:00

abstract：:Responses from 2-4 muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles were simultaneously recorded in cats anaesthetized with alpha-chloralose. It was demonstrated that stretch of the anterior cruciate ligament (ACL) of the ipsilateral knee causes changes in dynamic and/or s...

journal_title：Neuroscience research

authors： Johansson H,Sjölander P,Sojka P

更新日期：1990-04-01 00:00:00

abstract：:Stroke is a common cause of death and severe disability among adults in developed countries. Cigarette smoking adversely affects human health in many ways and is considered to be a risk factor for a stroke. However, the mechanism that determines the relative importance of neurotrophins in this process remains unclear....

journal_title：Neuroscience research

authors： Yang JT,Chang CN,Wu JH,Chung CY,Weng HH,Cheng WC,Lee TH

更新日期：2008-04-01 00:00:00

abstract：:In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the...

journal_title：Neuroscience research

authors： Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Y

更新日期：1998-04-01 00:00:00

abstract：:Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...

journal_title：Neuroscience research

authors： Matsui H

更新日期：2017-07-01 00:00:00

abstract：:We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...

journal_title：Neuroscience research

authors： Wakusawa K,Sugiura M,Sassa Y,Jeong H,Yomogida Y,Horie K,Sato S,Yokoyama H,Kure S,Takei N,Mori N,Kawashima R

更新日期：2015-01-01 00:00:00

abstract：:Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune re...

journal_title：Neuroscience research

authors： Ding L,Meng Y,Zhang HY,Yin WC,Yan Y,Cao YP

更新日期：2017-06-01 00:00:00

abstract：:The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

journal_title：Neuroscience research

authors： Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

更新日期：2006-12-01 00:00:00

abstract：:Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, tota...

journal_title：Neuroscience research

authors： Santiard-Baron D,Aupetit J,Janel N

更新日期：2005-12-01 00:00:00

abstract：:Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...

journal_title：Neuroscience research

authors： Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

更新日期：2019-07-01 00:00:00

abstract：:We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...

journal_title：Neuroscience research

authors： Nishitani S,Miyamura T,Tagawa M,Sumi M,Takase R,Doi H,Moriuchi H,Shinohara K

更新日期：2009-01-01 00:00:00

abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...

journal_title：Neuroscience research

authors： Imamura N,Hida H,Aihara N,Ishida K,Kanda Y,Nishino H,Yamada K

更新日期：2003-07-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) is a major component of the cell wall of gram negative bacteria contributing to the pathogenesis of bacterial infection, in particular in those diseases affecting central nervous system and reproductive tissues. The present work is an attempt to study the regulation of steroidogenic ...

journal_title：Neuroscience research

authors： Sadasivam M,Ramatchandirin B,Ayyanar A,Prahalathan C

更新日期：2014-06-01 00:00:00