Abstract:
:Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, total plasma homocysteine levels were evaluated in transgenic mouse models that exhibit abnormalities in their brains that are similar to Alzheimer's patients. No significant difference was observed in blood of murine models compared to control mice, indicating that elevated plasma homocysteine level seems to be a risk marker at the most.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Santiard-Baron D,Aupetit J,Janel Ndoi
10.1016/j.neures.2005.09.001subject
Has Abstractpub_date
2005-12-01 00:00:00pages
447-9issue
4eissn
0168-0102issn
1872-8111pii
S0168-0102(05)00240-3journal_volume
53pub_type
杂志文章abstract::The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.02.006
更新日期:2012-05-01 00:00:00
abstract::We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.10.007
更新日期:2009-01-01 00:00:00
abstract::Neonatal Brachial Plexus Palsy (NBPP) may lead to permanent impairment of arm function. As NBPP occurs when central motor programs develop, these may be ill-formed. We studied elbow flexion and motor imagery with fMRI to search for abnormal motor programming. We compared the cortical activity of adults with conservati...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.05.001
更新日期:2017-10-01 00:00:00
abstract::Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00033-9
更新日期:1998-06-01 00:00:00
abstract::Stem cells represent a potential cellular resource in the development of regenerative medicine approaches to the treatment of pathologies in which specific cells are degenerated or damaged by genetic abnormality, disease, or injury. Securing sufficient supplies of cells suited to the demands of cell transplantation, h...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.11.011
更新日期:2016-06-01 00:00:00
abstract::Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00216-4
更新日期:2001-06-01 00:00:00
abstract::Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00255-3
更新日期:2001-09-01 00:00:00
abstract::Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90081-z
更新日期:1993-02-01 00:00:00
abstract::We studied developmental changes in respiratory-like C4 activity and respiratory-related neurons in the ventrolateral medulla (VLM) of brainstem-spinal cord preparations from rat fetuses after embryonic day 16 (E16). In addition to respiratory nerve activity, non-respiratory activity was recorded from the C4 ventral r...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00322-4
更新日期:2002-03-01 00:00:00
abstract::In the mammalian central nervous system (CNS), transcription factor activator protein 2 (AP-2) is one of the critical regulatory factors for neural gene expression and neural development. As AP-2 has diverged into several subtypes, i.e. AP-2alpha, -2beta, and 2.2, we investigated the distribution of the AP-2 subtypes ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(99)00017-6
更新日期:1999-04-01 00:00:00
abstract::The contribution of nociceptive Aδ-fibres and C-fibres of the central pad of the foot to nociceptive spinal flexor reflex pathways (FRA-type) and to nociceptive excitatory reflex pathways to foot extensors (non-FRA type) was investigated in high spinal cats. Persisting effects after complete blocking of A-fibres by te...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.12.005
更新日期:2011-03-01 00:00:00
abstract::Some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. However it is not clear whether impairment of long-term potentiation depends on the oxidative stress evoked by sleep deprivation protocol. In this study we aimed to investigate the effects of...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.01.008
更新日期:2011-05-01 00:00:00
abstract::Amphibian metamorphosis is characterized by rapid tissue remodeling and drastic changes in the body structure and function. Like other organs, olfactory system also undergoes a dramatic rearrangement as the animal experiences transition from aquatic to terrestrial habitat. Reactive oxygen species (ROS) are known to pl...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.11.005
更新日期:2012-02-01 00:00:00
abstract::In anesthetized and immobilized Japanese monkeys (Macaca fuscata), intraretinal conduction velocities of the ganglion cell axons were measured. The field potentials elicited by optic chiasm shocks consisted of fast and slow components with estimated conduction velocities of 1.19 and 0.72 m/s in recordings from the opt...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(88)90006-5
更新日期:1988-10-01 00:00:00
abstract::Using standard intracellular recording techniques 38 nonpyramidal cells or interneurons have been sampled in hippocampal slices of the rat. Among 38 physiologically identified interneurons, all 27 cells labeled with biocytin were morphologically demonstrated to be nonpyramidal and nongranule cells. The vast majority o...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90013-2
更新日期:1994-02-01 00:00:00
abstract::Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential l...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00201-8
更新日期:2003-01-01 00:00:00
abstract::Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.11.011
更新日期:2008-03-01 00:00:00
abstract::Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.02.004
更新日期:2020-02-01 00:00:00
abstract::Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.008
更新日期:2019-12-01 00:00:00
abstract::This paper describes for the first time the phenomenon of spatio-temporal mapping of interchannel temporal coincidences of rapid transition processes (RTPs) in multiple EEG frequencies. It is suggested that RTPs in multiple EEG frequencies found in different EEG channels could reflect the process of switching between ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.07.2031
更新日期:2010-11-01 00:00:00
abstract::The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.09.005
更新日期:2016-04-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.11.012
更新日期:2018-01-01 00:00:00
abstract::The role of cholinergic basal forebrain inputs to cerebral cortex in regulating regional nerve growth factor (NGF) secretion was examined in adult (4-6 months) and aged (29-31 months) rats. Halothane-anesthetized rats received unilateral electrical stimulation of the nucleus basalis of Meynert (NBM). NGF levels were m...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the n...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00184-6
更新日期:2003-10-01 00:00:00
abstract::The influence of the phosphorylation dephosphorylation states on the gamma-aminobutyric acid (GABA) transporter activity of synaptic plasma membranes (SPM) was studied by using either specific phosphatase inhibitors or activators. Calyculin A and okadaic acid (phosphatase 1 and phosphatase 2A inhibitors) inhibited the...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00107-2
更新日期:1999-01-01 00:00:00
abstract::By combining biochemical, molecular and immunohistochemical approaches, we have investigated the presence of metabotropic glutamate receptors (mGluRs) belonging to the subtype 5 in rat and human spinal cords and the developmental changes in their expression. A polyclonal antibody raised against the carboxy-terminal po...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)01175-9
更新日期:1997-05-01 00:00:00
abstract::In 15 cats with implantations of crystalline HRP-WGA in the cerebellar nuclei and tetramethylbenzidine histochemistry, the pontine nuclei were carefully examined for presence of retrogradely labelled cells. Findings in the nucleus reticularis tegmenti pontis and the inferior olive, both known to project to the cerebel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90013-1
更新日期:1986-11-01 00:00:00
abstract::Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.04.003
更新日期:2013-07-01 00:00:00
abstract::The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00288-7
更新日期:2001-11-01 00:00:00