Abstract：
:Stroke is a common cause of death and severe disability among adults in developed countries. Cigarette smoking adversely affects human health in many ways and is considered to be a risk factor for a stroke. However, the mechanism that determines the relative importance of neurotrophins in this process remains unclear. To study the effect of chronic cigarette smoking on ischemic stroke, in situ hybridization and immunohistochemistry were employed to detect the mRNA and protein expression of neurotrophin-3 (NT-3), respectively, which is thought to play a critical role in protection against neuronal death in brain ischemia. Rats, with or without chronic cigarette smoking, were subjected to 20 min of transient forebrain ischemia. Distribution and quantification of mRNA and protein of NT-3 in the whole hippocampus and the cell death in the hippocampal CA1-CA3 regions were determined in these rats. Experimental results show that chronic cigarette smoking produces a significantly delay and persistent down-regulation of ischemia-induced NT-3 mRNA and protein changes at 6-24h post-ischemia, and seemingly increases neuron death 7 days after reperfusion. These experimental results indicate that by influencing NT-3 expression, directly or indirectly, chronic cigarette smoking has a potentially harmful effect when acute brain ischemia attacks.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Yang JT,Chang CN,Wu JH,Chung CY,Weng HH,Cheng WC,Lee THdoi
10.1016/j.neures.2008.01.001subject
Has Abstractpub_date
2008-04-01 00:00:00pages
431-8issue
4eissn
0168-0102issn
1872-8111pii
S0168-0102(08)00007-2journal_volume
60pub_type
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