Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.


:In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission.


Neurosci Res


Neuroscience research


Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Y




Has Abstract


1998-04-01 00:00:00














  • Light microscopic comparison of the patterns of glutamate-like and homocysteate-like immunoreactivities in rat dorsal lateral geniculate after combined visual cortical and retinal ablations.

    abstract::To study the contribution of retinal and cortical afferents to the patterns of glutamate- and homocysteate-like immunoreactivities in dorsal lateral geniculate, combined retinal and cortical ablations were performed in rats. In controls, glutamate immunoreactivity was in terminal-like dots and neurons. Homocysteate im...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Grandes P,Mateos JM,Azkue J,Sarría R,Cuénod M,Streit P

    更新日期:1997-04-01 00:00:00

  • Evaluation of voxel-based group-level analysis of diffusion tensor images using simulated brain lesions.

    abstract::We simulated brain lesions in mean diffusivity (MD) and fractional anisotropy (FA) images of healthy subjects to evaluate the performance of voxel-based analysis (VBA) with SPM2. We increased MD and decreased FA, simulating the most typical abnormalities in brain pathologies, in the superior longitudinal fasciculus (S...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hiltunen J,Seppä M,Hari R

    更新日期:2011-12-01 00:00:00

  • Regulatory roles of Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 2A on the quisqualic acid-induced K+-current response in identified neurons of Aplysia.

    abstract::In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kimura S,Kawasaki S,Watanabe S,Fujita R,Sasaki K

    更新日期:2008-01-01 00:00:00

  • Antisense hippocampal knockdown of NMDA-NR1 by HVJ-liposome vector induces deficit of prepulse inhibition but not of spatial memory.

    abstract::Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Inada K,Ishigooka J,Anzai T,Suzuki E,Miyaoka H,Saji M

    更新日期:2003-04-01 00:00:00

  • Activity in receptor afferents from the anterior cruciate ligament evokes reflex effects on fusimotor neurones.

    abstract::Responses from 2-4 muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles were simultaneously recorded in cats anaesthetized with alpha-chloralose. It was demonstrated that stretch of the anterior cruciate ligament (ACL) of the ipsilateral knee causes changes in dynamic and/or s...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Johansson H,Sjölander P,Sojka P

    更新日期:1990-04-01 00:00:00

  • Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain.

    abstract::ATP-sensitive K(+) (K(ATP)) channel subunits SUR2A and SUR2B in the rat brain were investigated by RT-PCR assay, western blot analysis, in situ hybridization histochemistry, and immunohistochemical staining. The results show that the mRNA and protein of SUR2A and SUR2B are expressed in whole rat brain extracts and sel...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Zhou M,He HJ,Tanaka O,Sekiguchi M,Kawahara K,Abe H

    更新日期:2012-10-01 00:00:00

  • A combined scoring method to assess behavioral recovery after mouse spinal cord injury.

    abstract::Although the rat has been the predominant rodent used to investigate the pathophysiology and treatment of experimental spinal cord injury (SCI), the increasing availability of transgenic animals has led to greater use of mouse models. However, behavioral assessment after SCI in mice has been less extensively investiga...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Pajoohesh-Ganji A,Byrnes KR,Fatemi G,Faden AI

    更新日期:2010-06-01 00:00:00

  • Ulk1 protects against ethanol-induced neuronal stress and cognition-related behavioral deficits.

    abstract::Alcoholism is a psychiatric condition that develops through neuroadaptations in response to neuronal stresses caused by chronic ethanol intake. Neurons can adapt to ethanol-induced metabolic changes by activating cellular protective mechanisms, including autophagy. Here we show that expression of Ulk1, a gene critical...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sumitomo A,Ueta K,Mauchi S,Hirai K,Horike K,Hikida T,Sakurai T,Sawa A,Tomoda T

    更新日期:2017-04-01 00:00:00

  • Uni-directional differentiation of mouse embryonic stem cells into neurons by the neural stem sphere method.

    abstract::We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Otsu M,Sai T,Nakayama T,Murakami K,Inoue N

    更新日期:2011-04-01 00:00:00

  • Effects of prenatal stress and neonatal handling on anxiety, spatial learning and serotonergic system of male offspring mice.

    abstract::Environmental factors during perinatal period have various effects on behavior. The present study examined the effects of prenatal stress and neonatal handling on anxiety and spatial learning of offspring. Prenatal stress increased anxiety-related behavior of adult offspring, whereas neonatal handling had no effect. I...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Akatsu S,Ishikawa C,Takemura K,Ohtani A,Shiga T

    更新日期:2015-12-01 00:00:00

  • Receptive field properties of cat perigeniculate neurons correlate with excitatory and inhibitory connectivity to LGN relay neurons.

    abstract::The cat perigeniculate nucleus (PGN) is a visual sector of the thalamic reticular nucleus that consists of GABAergic neurons. It receives excitatory axon-collateral input from relay neurons of the dorsal lateral geniculate nucleus (LGN) to which it provides inhibitory input. Thus, it is usually argued that the PGN wor...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Osaki H,Naito T,Soma S,Sato H

    更新日期:2018-07-01 00:00:00

  • Effect of isolation on classical conditioned histamine release in guinea pigs.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Irie M,Nagata S,Endo Y

    更新日期:2002-09-01 00:00:00

  • Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice.

    abstract::Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

    更新日期:2001-03-01 00:00:00

  • Bidirectional synaptic plasticity in response to single or paired pulse activation of NMDA receptors.

    abstract::It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Huang FS,Abbas AK,Li R,Afanasenkau D,Wigström H

    更新日期:2010-06-01 00:00:00

  • Repetitive transcranial magnetic stimulation ameliorates recognition memory impairment induced by hindlimb unloading in mice associated with BDNF/TrkB signaling.

    abstract::Repetitive transcranial magnetic stimulation (rTMS), which could improve learning and memory, is widely used in psychiatry and neurology as a therapeutic approach. There are few studies reporting effective countermeasures to cognition decline in astronauts during space flight. Accordingly, we examined whether rTMS was...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Zhai B,Fu J,Xiang S,Shang Y,Yan Y,Yin T,Zhang T

    更新日期:2020-04-01 00:00:00

  • Change in phase synchronization of local field potentials in anesthetized rats after chronic dopamine depletion.

    abstract::In order to investigate temporal characteristics of oscillatory neural activity and the effect of chronic dopamine depletion on it, local field potentials were measured in anesthetized rats without or with a 6-OHDA lesion at either the ventral tegmental area or the substantia nigra compacta, using a pair of electrodes...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lee KM,Ahn TB,Jeon BS,Kim DG

    更新日期:2004-06-01 00:00:00

  • Subcortical vascular dementia.

    abstract::Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Tomimoto H

    更新日期:2011-11-01 00:00:00

  • Protein kinase C delta- and epsilon-subspecies in rat central nervous tissue; differential distribution and phorbol ester-induced redistribution in synaptosomes.

    abstract::Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Matsushima S,Nakamura S

    更新日期:1994-05-01 00:00:00

  • Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.

    abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

    更新日期:2010-04-01 00:00:00

  • Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.

    abstract::L-3,4-Dihydroxyphenylalanine (DOPA) has been believed to be a precursor of dopamine, and itself being an inert amino acid. Previously, we have proposed DOPA as a neurotransmitter candidate in the central nervous system (CNS). Recent findings have suggested DOPA as an endogenous agonist of a G-protein coupled receptor,...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Masukawa D,Nakamura F,Koga M,Kamiya M,Chen S,Yamashita N,Arai N,Goshima Y

    更新日期:2014-11-01 00:00:00

  • Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation.

    abstract::Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lin SH,Miyata S,Weng W,Matsunaga W,Ichikawa J,Furuya K,Nakashima T,Kiyohara T

    更新日期:1998-12-01 00:00:00

  • Reticulo-collicular and spino-collicular projections involved in eye and eyelid movements during the blink reflex.

    abstract::Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Smit AE,Buisseret P,Buisseret-Delmas C,De Zeeuw CI,VanderWerf F,Zerari-Mailly F

    更新日期:2006-12-01 00:00:00

  • Corticotropin releasing factor and galanin-containing neurons projecting to the median eminence of the rat.

    abstract::To identify corticotropin releasing factor (CRF)- and galanin (GAL)-containing neurons projecting to the median eminence, a retrograde tracing method with True blue was combined with a double-staining method. It was demonstrated that some True blue-labeled CRF neurons in the paraventricular nucleus were also immunorea...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Niimi M,Takahara J,Kawanishi K

    更新日期:1992-09-01 00:00:00

  • Phasic nicotinic potentiation of frog retinotectal transmission enhances intrinsic activity of tectum column.

    abstract::It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Baginskas A,Kuraite V,Kuras A

    更新日期:2012-09-01 00:00:00

  • Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice.

    abstract::Diazepam binding inhibitor (DBI), a putative endogenous polypeptide ligand for benzodiazepine (BZD) receptors, has been shown to act as an inverse BZD receptor agonist in the brain. We previously suggested that the social isolation stress-induced decrease in pentobarbital sleeping time in mice was partly due to an inc...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Dong E,Matsumoto K,Tohda M,Kaneko Y,Watanabe H

    更新日期:1999-03-01 00:00:00

  • The effect of acute kainic acid treatment on dopamine D2 receptors in rat brain.

    abstract::Acute exposure to kainic acid (KA) induces neurochemical changes in dopaminergic systems in the brain and the aim of the present study was to investigate the acute toxicity of KA upon dopamine D2 receptors. Adult rats were injected intraperitoneally with either saline or 16 mg/kg KA. Brains were removed after 4 h. Mem...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ridd MJ,Kitchen I,Fosbraey P

    更新日期:1998-03-01 00:00:00

  • Quantitative analysis of spontaneous saccade-like rapid eye movements in C57BL/6 mice.

    abstract::Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sakatani T,Isa T

    更新日期:2007-07-01 00:00:00

  • Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats.

    abstract::Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injur...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Komoltsev IG,Frankevich SO,Shirobokova NI,Volkova AA,Levshina IP,Novikova MR,Manolova AO,Gulyaeva NV

    更新日期:2020-05-24 00:00:00

  • Evidence of functional hyperemia in the rat hippocampus during mild treadmill running.

    abstract::Exercise appears to improve hippocampal plasticity and cognitive function, leading us to postulate that exercise may activate hippocampal neurons, which in turn increase hippocampal cerebral blood flow (Hip-CBF). Recent studies using laser-Doppler flowmetry (LDF) have shown that Hip-CBF increases with behavior and loc...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Nishijima T,Soya H

    更新日期:2006-03-01 00:00:00

  • Effect of different spinal cord lesions on visually guided switching of target-reaching in cats.

    abstract::It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Alstermark B,Górska T,Lundberg A,Pettersson LG,Walkowska M

    更新日期:1987-10-01 00:00:00