Abstract:
:In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Ydoi
10.1016/s0168-0102(98)00015-7subject
Has Abstractpub_date
1998-04-01 00:00:00pages
355-60issue
4eissn
0168-0102issn
1872-8111pii
S0168010298000157journal_volume
30pub_type
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