Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.

Abstract:

:In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Y

doi

10.1016/s0168-0102(98)00015-7

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

355-60

issue

4

eissn

0168-0102

issn

1872-8111

pii

S0168010298000157

journal_volume

30

pub_type

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