Abstract:
:Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured using paired-pulse transcranial magnetic stimulation (interstimulus interval=2ms) in samples of young and healthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard test and two isometric force-matching tasks. There was an age-related decrease in SICI and an age-related decline in all dexterity measures. The level of SICI was not correlated with any of the dexterity measures, but the appearance of atypical facilitation (rather than inhibition) in some subjects was associated with impaired pegboard performance but not force-matching performance. We conclude that SICI at rest is reduced with healthy aging but this loss of SICI does not directly contribute to the loss of dexterity; a shift in the balance of facilitatory and inhibitory processes in motor cortex to facilitation might interfere with sequenced hand movements.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Marneweck M,Loftus A,Hammond Gdoi
10.1016/j.neures.2011.04.004subject
Has Abstractpub_date
2011-08-01 00:00:00pages
408-14issue
4eissn
0168-0102issn
1872-8111pii
S0168-0102(11)00122-2journal_volume
70pub_type
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