Short-interval intracortical inhibition and manual dexterity in healthy aging.

Abstract:

:Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured using paired-pulse transcranial magnetic stimulation (interstimulus interval=2ms) in samples of young and healthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard test and two isometric force-matching tasks. There was an age-related decrease in SICI and an age-related decline in all dexterity measures. The level of SICI was not correlated with any of the dexterity measures, but the appearance of atypical facilitation (rather than inhibition) in some subjects was associated with impaired pegboard performance but not force-matching performance. We conclude that SICI at rest is reduced with healthy aging but this loss of SICI does not directly contribute to the loss of dexterity; a shift in the balance of facilitatory and inhibitory processes in motor cortex to facilitation might interfere with sequenced hand movements.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Marneweck M,Loftus A,Hammond G

doi

10.1016/j.neures.2011.04.004

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

408-14

issue

4

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(11)00122-2

journal_volume

70

pub_type

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