Abstract:
:Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investigated bilaterally their reflex responses conditioned by (a) acute 'myositis' induced by intramuscular carrageenan; and (b) sub-acute 'myositis' induced by infusion of complete Freund's adjuvant (CFA). Reflex transmission was detected by monosynaptic testing and c-fos staining used to identify increased neuronal activity. In all control experiments with chemical stimulation of group III/IV afferents, ipsilateral responses conformed to the flexor reflex pattern. However, the expected contralateral facilitation of GS motoneurones occurred in fewer than 50% trials while only 9% of trials induced contralateral inhibition of flexor posterior-biceps-semitendinosus (PBSt) motoneurones. During carrageenan acute myositis contralateral PBSt was transiently facilitated by selective activation of group III/IV afferents. During CFA-induced myositis, contralateral only inhibition of GS motoneurones occurred instead of any facilitation, while bidirectionally a crossed facilitation of PBST dominated. These reflex changes were mirrored in an enhanced number of neurones with enhanced c-fos expression. Muscle pain, particularly if chronically persistent, requires another behavioural response pattern than acute exteroceptive pain.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Schomburg ED,Steffens H,Pilyavskii AI,Maisky VA,Brück W,Dibaj P,Sears TAdoi
10.1016/j.neures.2015.01.003subject
Has Abstractpub_date
2015-06-01 00:00:00pages
51-8eissn
0168-0102issn
1872-8111pii
S0168-0102(15)00004-8journal_volume
95pub_type
杂志文章abstract::Changes in voltage-dependent Na+ (INa) and Ca2+ currents (ICa) were investigated in PC12 cells cultured without or with either nerve growth factor (NGF) or 8-Br-cAMP for 10 days. Current recordings were made in the whole-cell mode by using the conventional patch-clamp technique under voltage-clamp conditions. Membrane...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90081-z
更新日期:1993-02-01 00:00:00
abstract::Communication in the central nervous system (CNS) occurs through initiation and propagation of action potentials at excitable domains along axons. Action potentials generated at the axon initial segment (AIS) are regenerated at nodes of Ranvier through the process of saltatory conduction. Proper formation and maintena...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2016.09.010
更新日期:2017-03-01 00:00:00
abstract::We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.02.014
更新日期:2006-06-01 00:00:00
abstract::In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00015-7
更新日期:1998-04-01 00:00:00
abstract::We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those o...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.06.003
更新日期:2015-11-01 00:00:00
abstract::Exercise appears to improve hippocampal plasticity and cognitive function, leading us to postulate that exercise may activate hippocampal neurons, which in turn increase hippocampal cerebral blood flow (Hip-CBF). Recent studies using laser-Doppler flowmetry (LDF) have shown that Hip-CBF increases with behavior and loc...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.11.005
更新日期:2006-03-01 00:00:00
abstract::Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.008
更新日期:2019-12-01 00:00:00
abstract::Changes in the features of responses of cortical taste neurons were studied in granular insular (GI) and dysgranular insular (DI) areas of urethane-anesthetized SD rats of four age groups (4-10, 14-20, 25-35 and > 90 days). Stimuli included four basic taste stimuli, 0.1 M NH4Cl, and the water extract of a food pellet,...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90082-5
更新日期:1994-06-01 00:00:00
abstract::A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.05.009
更新日期:2006-09-01 00:00:00
abstract::Tissue-type plasminogen activator (tPA) is a serine protease that converts the inactive precursor plasminogen to the active protease plasmin. In the central nervous system, tPA has been suggested to participate in plasticity, memory and the neuronal degeneration caused by excitotoxins, but its precise functions during...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00125-4
更新日期:1999-02-01 00:00:00
abstract::GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01102-9
更新日期:1996-10-01 00:00:00
abstract::Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(84)90009-9
更新日期:1984-12-01 00:00:00
abstract::Intracellular pH (pH(i)) plays an important role in the regulation of central nervous system function. In the present study, we examined whether hydrogen sulfide (H(2)S), a recently recognized neuromodulator, regulates pH(i) in rat primary cultured glia cells. pH(i) was measured with a fluorescent sensitive dye, BCECF...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.09.1713
更新日期:2010-01-01 00:00:00
abstract::Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)01155-3
更新日期:1997-03-01 00:00:00
abstract::In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.02.002
更新日期:2009-05-01 00:00:00
abstract::The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)00864-c
更新日期:1995-02-01 00:00:00
abstract::Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.06.007
更新日期:2009-10-01 00:00:00
abstract::Responses from 2-4 muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles were simultaneously recorded in cats anaesthetized with alpha-chloralose. It was demonstrated that stretch of the anterior cruciate ligament (ACL) of the ipsilateral knee causes changes in dynamic and/or s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90057-l
更新日期:1990-04-01 00:00:00
abstract::To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.12.005
更新日期:2010-04-01 00:00:00
abstract::Using Mayahara's method, the distribution of K(+)-dependent p-nitrophenylphosphatase activity was examined electron microscopically in the synaptic regions of the cerebral cortex of 10, 15 and 60-day-old Wistar rats. The enzyme achieved gradually its characteristic localization and uniform distribution. The main devel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)01004-1
更新日期:1996-02-01 00:00:00
abstract::In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00897-2
更新日期:1995-05-01 00:00:00
abstract::Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2011.11.002
更新日期:2012-02-01 00:00:00
abstract::Steroid hormones substantially influence brain development, reproduction sexual differentiation and emotion. These effects are mediated by steroid hormone receptors and cofactors, which directly regulate gene expression. Deciphering how and where these transcriptional activators occur in a cell provides the groundwork...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(01)00253-x
更新日期:2001-07-01 00:00:00
abstract::Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.06.021
更新日期:2005-11-01 00:00:00
abstract::The Approach-Avoidance Task (AAT) measures automatic approach-avoidance tendencies and their regulation: compatible reactions (approach positive, avoid negative) are faster than incompatible ones (approach negative, avoid positive). The present study assessed event-related potentials (ERPs) in 15 healthy persons for d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.12.005
更新日期:2013-03-01 00:00:00
abstract::Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-lev...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2019.12.004
更新日期:2020-07-01 00:00:00
abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.01.005
更新日期:2005-05-01 00:00:00
abstract::Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00185-8
更新日期:2003-09-01 00:00:00
abstract::Sizes of neuronal somata in the cat cervical dorsal root ganglia were determined at different levels (C1-C8). The average value and class distribution of mean cell diameter were analyzed. The ganglia from C1 to C5 could be clearly distinguished from those at levels of brachial plexus afferents (C6-C8) with respect to ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90009-4
更新日期:1990-02-01 00:00:00
abstract::The effects of acupuncture-like stimulation of the various segmental areas on gastric motility were examined in anesthetized rats. An acupuncture needle (diameter 340 microns) was inserted into the skin and underlying muscles at a depth of 4-5 mm and was twisted right and left once every second for 60 s. Gastric motil...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90105-y
更新日期:1993-10-01 00:00:00