Abstract：
:Increased levels of proinflammatory cytokines have been implicated in schizophrenia; however, their pathophysiological roles in abnormal brain dysfunctions remain unclear. We evaluated the effect of proinflammatory cytokines on a high-fat diet (HFD)-induced prepulse inhibition (PPI) deficits in the acoustic startle response. Eight-week-old male C57BL/6J mice were fed a HFD for 3 weeks and then PPI was examined. HFD significantly induced PPI deficits and increased plasma IL-6, but not TNFα, levels. Interestingly, MR16-1 administration during the HFD period ameliorated PPI deficits. Further, in the striatum of HFD-fed mice, phosphorylation of GSK3β, but not GSK3α, was significantly increased; this increase was attenuated by MR16-1, although the protein levels of GSK3α and β were not altered. There were no significant differences in either phosphorylation or protein levels of GSK3α, β in the PFC during the HFD period. These results suggest that increased IL-6 levels during HFD may induce sensorimotor gating deficits, likely through the alteration of striatal GSK3β phosphorylation. MR16-1 might have a beneficial effect on such HFD-induced sensorimotor gating deficits.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Wakabayashi C,Kunugi Hdoi
10.1016/j.neures.2018.10.004subject
Has Abstractpub_date
2019-10-01 00:00:00pages
33-38eissn
0168-0102issn
1872-8111pii
S0168-0102(18)30328-6journal_volume
147pub_type
杂志文章abstract：:A time production test was performed in seven normal females and seven females with premenstrual syndrome (PMS). We used a time production test for six time intervals (6, 12, 24, 36, 48, 60 s). Time production tests were performed at 08:00, 14:00 and 20:00 h in the follicular, early luteal and late luteal phases (LLP)...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00290-5
更新日期：2001-12-01 00:00:00
abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.07.003
更新日期：2020-06-01 00:00:00
abstract：:Many different kinds of voltage-gated ion channels (Na+ channels, K+ channels, Ca2+ channels) exist at neuronal dendrites. Integration of dendritic electric signals (excitatory postsynaptic potentials (EPSPs), inhibitory postsynaptic potentials (IPSPs) and action potentials) and/or non-electric signals (Ca2+ and secon...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/s0168-0102(00)00120-6
更新日期：2000-07-01 00:00:00
abstract：:Contradictory data on behavioral changes in MPTP-treated C57BL/6 mice have been reported, even though the toxin-treated mice have been widely used for non-clinical studies as an in vivo model of Parkinson's disease (PD). We found that the duration of immobility in the tail suspension test (TST) was significantly incre...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.11.008
更新日期：2005-03-01 00:00:00
abstract：:To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.015
更新日期：2009-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.11.009
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.12.001
更新日期：2019-11-01 00:00:00
abstract：:The effects of morphine on the reflex discharges in sympathetic efferents recorded from branches of the inferior cardiac nerve (ICN) were studied in rats anesthetized with alpha-chloralose and urethane. Somatocardiac sympathetic A- and C-reflexes were elicited by single shock electrical stimulation of myelinated (A) a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90049-i
更新日期：1992-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.12.019
更新日期：2005-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.02.008
更新日期：2004-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00017-6
更新日期：1999-04-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.06.016
更新日期：2009-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.04.004
更新日期：2015-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00191-8
更新日期：2003-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.06.004
更新日期：2018-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.03.002
更新日期：2006-06-01 00:00:00
abstract：:The periaqueductal gray (PAG)-nucleus retroambiguus (NRA) pathway has been known to be involved in the control of vocalization and sexual behavior. To know how the amygdaloid complex influences the PAG-NRA pathway, here we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.10.004
更新日期：2008-12-01 00:00:00
abstract：:The distribution of a live attenuated herpes simplex virus (betaH1)-mediated gene delivery into the central nervous system (CNS) was regulated by growth inhibition with ganciclovir (GCV) and the effect of this transgene expression system on the physiologic response was characterized by the acoustic startle response an...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00235-3
更新日期：2003-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.12.008
更新日期：2018-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00099-0
更新日期：1997-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.04.003
更新日期：2013-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00075-3
更新日期：1998-10-01 00:00:00
abstract：:How the nervous system controls the sensation and memory of information from the environment is an essential question. The nematode Caenorhabditis elegans is a useful model for elucidating neural information processing that mediates sensation and memory. The entire nervous system of C. elegans consists of only 302 neu...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.03.008
更新日期：2013-07-01 00:00:00
abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.10.001
更新日期：2005-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90060-x
更新日期：1986-09-01 00:00:00
abstract：:Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.02.004
更新日期：2020-02-01 00:00:00
abstract：:According to the amyloid hypothesis for the pathogenesis of Alzheimer's disease (AD), amyloid beta peptide (Abeta) directly affects neurons, leading to neurodegeneration and tau phosphorylation, followed by the production of paired helical filaments (PHF) in neurofibrillary tangles (NFT). To analyze the relationship b...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00061-3
更新日期：1998-08-01 00:00:00
abstract：:Mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy, the most frequently occurring form of hereditary optic neuropathy. But although the involvement of structural abnormalities of the enzyme in this neurodegenerative disease is clear, little is known about the cell ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.02.010
更新日期：2006-06-01 00:00:00
abstract：:The influence of the phosphorylation dephosphorylation states on the gamma-aminobutyric acid (GABA) transporter activity of synaptic plasma membranes (SPM) was studied by using either specific phosphatase inhibitors or activators. Calyculin A and okadaic acid (phosphatase 1 and phosphatase 2A inhibitors) inhibited the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00107-2
更新日期：1999-01-01 00:00:00
abstract：:Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.008
更新日期：2019-12-01 00:00:00
