Neuroanatomical and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat.


:The periaqueductal gray (PAG)-nucleus retroambiguus (NRA) pathway has been known to be involved in the control of vocalization and sexual behavior. To know how the amygdaloid complex influences the PAG-NRA pathway, here we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and the PAG neurons that project to the NRA by using anterograde and retrograde tract-tracing techniques in the rat. After ipsilateral injections of biotinylated dextran amine (BDA) into the CeA and cholera toxin B subunit (CTb) into the NRA, the prominent overlapping distribution of BDA-labeled axon terminals and CTb-labeled neurons was found ipsilaterally in the lateral/ventrolateral PAG, where some of the BDA-labeled terminals made symmetrical synaptic contacts with somata and dendrites of the CTb-labeled neurons. After CTb injection into the lateral/ventrolateral PAG, CTb-labeled neurons were distributed mainly in the medial division of the CeA. After BDA injection into the lateral/ventrolateral PAG, BDA-labeled fibers were distributed mainly in and around the NRA within the medulla oblongata. Using a combined retrograde tracing and in situ hybridization technique, we further demonstrated that more than half of the CeA neurons labeled with Fluoro-Gold (FG) injected into the lateral/ventrolateral PAG were positive for glutamic acid decarboxylase 67 mRNA and that the vast majority of PAG neurons labeled with FG injected into the NRA expressed vesicular glutamate transporter 2 mRNA. The present results suggest that the glutamatergic PAG-NRA pathway is under the inhibitory influence of the GABAergic CeA neurons.


Neurosci Res


Neuroscience research


Oka T,Tsumori T,Yokota S,Yasui Y




Has Abstract


2008-12-01 00:00:00














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    journal_title:Neuroscience research

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    authors: Mori A,Ohashi S,Nakai M,Moriizumi T,Mitsumoto Y

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  • Increased brain activation during motor imagery suggests central abnormality in Neonatal Brachial Plexus Palsy.

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    journal_title:Neuroscience research

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    authors: Anguelova GV,Rombouts SARB,van Dijk JG,Buur PF,Malessy MJA

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    journal_title:Neuroscience research

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    authors: Hattori T,Takei N,Mizuno Y,Kato K,Kohsaka S

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    journal_title:Neuroscience research

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    authors: Asada Y,Kawaguchi S,Hayashi H,Nakamura T

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    journal_title:Neuroscience research

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    authors: Funahashi M,Mitoh Y,Akaike T,Matsuo R

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  • Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism.

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    pub_type: 临床试验,杂志文章


    authors: Watanabe A,Kato N,Kato T

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    journal_title:Neuroscience research

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tamai Y,Miyashita E,Nakai M

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Wang SW,Ren BX,Qian F,Luo XZ,Tang X,Peng XC,Huang JR,Tang FR

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Dai H,Kaneko K,Kato H,Fujii S,Jing Y,Xu A,Sakurai E,Kato M,Okamura N,Kuramasu A,Yanai K

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