Abstract：
:Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of adult rabbits, cats and rats. A DNA fragment of 611 bp of this receptor was first isolated from rabbit. The nucleic acid sequence of this fragment was found to be 84.5% identical to that of rat. This specific 611 bp fragment was used as a probe to detect, either by Northern analysis or by the reverse transcription-polymerase chain reaction, the dopamine D1-receptor mRNA. The results revealed the presence of dopamine D1-receptor transcript in the carotid body as well as in the petrosal ganglion and the superior cervical ganglion from the three animal models studied here. The physiological significance of dopamine D1-receptor expression in the carotid body is discussed.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Bairam A,Frenette J,Dauphin C,Carroll JL,Khandjian EWdoi
10.1016/s0168-0102(98)00033-9subject
Has Abstractpub_date
1998-06-01 00:00:00pages
147-54issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(98)00033-9journal_volume
31pub_type
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