Neuronal protein GAP-43 is a member of novel group of brain acid-soluble proteins (BASPs).


:A group of brain acid-soluble proteins (BASPs) is preliminarily characterized. In some respects BASPs are similar to high mobility group (HMG) proteins, but in contrast to HMG, all BASPs are very acidic (pI 4.4-4.6) and show abnormal mobility during SDS-PAGE electrophoresis. BASP2-1 and BASP2-2 are identified as the two forms of neuronal protein GAP-43 (B-50, pp46, F1, neuromodulin). BASP1 and BASP3 are apparently novel brain proteins.


Neurosci Res


Neuroscience research


Mosevitsky MI,Novitskaya VA,Plekhanov AYu,Skladchikova GYu




Has Abstract


1994-03-01 00:00:00














  • Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism.

    abstract::The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kim JH,Park M,Yang SY,Jeong BS,Yoo HJ,Kim JW,Chung JH,Kim SA

    更新日期:2006-10-01 00:00:00

  • Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.

    abstract::L-3,4-Dihydroxyphenylalanine (DOPA) has been believed to be a precursor of dopamine, and itself being an inert amino acid. Previously, we have proposed DOPA as a neurotransmitter candidate in the central nervous system (CNS). Recent findings have suggested DOPA as an endogenous agonist of a G-protein coupled receptor,...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Masukawa D,Nakamura F,Koga M,Kamiya M,Chen S,Yamashita N,Arai N,Goshima Y

    更新日期:2014-11-01 00:00:00

  • The low levels of nerve growth factor and its upstream regulatory kinases in prion infection is reversed by resveratrol.

    abstract::Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hu C,Chen C,Chen J,Xiao K,Wang J,Shi Q,Ma Y,Gao LP,Wu YZ,Liu L,Xia Y,Yan P,Maimaitiming A,Zhou DH,Zhang LN,Chen ZB,Dong XP

    更新日期:2021-01-01 00:00:00

  • Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin.

    abstract::Maternal stress, viral infection, and obstetric complications, which trigger cytokine signaling, are hypothesized to be involved in schizophrenia and its related disorders. The etiologic contribution of individual cytokines to such psychiatric disorders, however, remains to be evaluated. To estimate the impact of peri...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tohmi M,Tsuda N,Watanabe Y,Kakita A,Nawa H

    更新日期:2004-09-01 00:00:00

  • The site of origin of calcitonin gene-related peptide-like immunoreactive afferents to the inferior olivary complex of the mouse.

    abstract::The intent of the present study is to define the brainstem nuclei which give rise to CGRP-immunolabeled afferents to the inferior olivary complex of the mouse. A technique which combines retrograde transport of fluorescent microspheres with immunohistochemistry was used to address this question. In the present study, ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Peltier AC,Bishop GA

    更新日期:1999-08-01 00:00:00

  • Event-related brain potentials to unfamiliar faces in explicit and implicit memory tasks.

    abstract::The purpose of this study was to investigate electrophysiological correlates related to the recognition of repeated faces in the intact human by means of event-related brain potentials (ERPs). A group of young healthy adults performed a continuous face recognition task, in which 240 unfamiliar faces were flashed upon ...

    journal_title:Neuroscience research

    pub_type: 临床试验,杂志文章


    authors: Münte TF,Brack M,Grootheer O,Wieringa BM,Matzke M,Johannes S

    更新日期:1997-07-01 00:00:00

  • Evoked local cerebral blood flow induced by somatosensory stimulation is proportional to the baseline flow.

    abstract::The purpose of this study was to determine the relationship between the increase in local cerebral blood flow during neuronal activation (evoked LCBF) and the baseline flow level. We measured the hemodynamics in alpha-chloralose-anesthetized rats using laser-Doppler flowmetry during somatosensory stimulation under the...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Matsuura T,Fujita H,Kashikura K,Kanno I

    更新日期:2000-12-01 00:00:00

  • Haloperidol reduces the sympathetic and thermogenic activation induced by orexin A.

    abstract::This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Monda M,Viggiano A,De Luca V

    更新日期:2003-01-01 00:00:00

  • Expression of dopamine D1-receptor mRNA in the carotid body of adult rabbits, cats and rats.

    abstract::Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Bairam A,Frenette J,Dauphin C,Carroll JL,Khandjian EW

    更新日期:1998-06-01 00:00:00

  • GABAergic input contributes to activity-dependent change in cell volume in the hippocampal CA1 region.

    abstract::Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Takagi S,Obata K,Tsubokawa H

    更新日期:2002-11-01 00:00:00

  • Up-regulation of P/Q-type voltage-gated Ca2+ channel immunoreactivity within parvalbumin positive neurons in the rat hippocampus following status epilepticus.

    abstract::To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kim JE,Kwak SE,Kim DS,Won MH,Choi HC,Song HK,Kim YI,Kang TC

    更新日期:2007-03-01 00:00:00

  • Motor deficits and hyperactivity in Dyt1 knockdown mice.

    abstract::The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Dang MT,Yokoi F,Pence MA,Li Y

    更新日期:2006-12-01 00:00:00

  • Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus.

    abstract::We investigated the distribution and colocalization pattern of the two corticosteroid receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the hippocampus and hypothalamus, the main target regions of corticosterone in the rat brain, using double immunofluorescence histochemistry in conjuncti...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Han F,Ozawa H,Matsuda K,Nishi M,Kawata M

    更新日期:2005-04-01 00:00:00

  • Event-related potentials during an auditory discrimination task in rats.

    abstract::Event-related potentials (ERPs) during an auditory discrimination task were recorded both on the surface and at a depth of the auditory cortex in rats. Ten-kilohertz rare and 5-kHz frequent tones were used with the probabilities of 0.2 and 0.8. Lever pressing within 2 s, following the onset of the rare tone, was rewar...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Iwanami A,Shinba T,Sumi M,Ozawa N,Yamamoto K

    更新日期:1994-11-01 00:00:00

  • Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice.

    abstract::Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Suzuki J,Oshima T,Yoshida N,Kimura R,Takata Y,Owada Y,Kobayashi T,Katori Y,Osumi N

    更新日期:2014-04-01 00:00:00

  • Somatic noxious mechanical stimulation induces Fos expression in the postsynaptic dorsal column neurons in laminae III and IV of the rat spinal dorsal horn.

    abstract::This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Day AS,Wen CY,Shieh JY,Sun WZ,Lue JH

    更新日期:2001-08-01 00:00:00

  • Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices.

    abstract::We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique. Application of 0.1 microM CCh to the slices significantly ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Shimoshige Y,Maeda T,Kaneko S,Akaike A,Satoh M

    更新日期:1997-02-01 00:00:00

  • Rapidly proliferating glial cells isolated from adult mouse brain have a differentiative capacity in response to cyclic AMP.

    abstract::A glial cell line designated as B2 was generated from primary cultures of oligodendrocytes/astrocytes isolated from an adult BALB/c mouse brain and maintained for over 1 year. Phenotypic characteristics of B2 cells were investigated by immunolabeling with cell type-specific markers for oligodendrocytes (O4 and galacto...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Satoh J,Tabira T,Kim SU

    更新日期:1994-08-01 00:00:00

  • Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.

    abstract::Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Murao N,Matsubara S,Matsuda T,Noguchi H,Mutoh T,Mutoh M,Koseki H,Namihira M,Nakashima K

    更新日期:2019-06-01 00:00:00

  • Axon collaterals of anterior semicircular canal-activated vestibular neurons and their coactivation of extraocular and neck motoneurons in the cat.

    abstract::We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Uchino Y,Hirai N

    更新日期:1984-10-01 00:00:00

  • Brain development and multiple molecular species of proteoglycan.

    abstract::The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Oohira A,Katoh-Semba R,Watanabe E,Matsui F

    更新日期:1994-09-01 00:00:00

  • Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants.

    abstract::Recent rapid progress in genome analysis and large-scale consortia has made it possible to discover variants with a variety of allele frequencies and effect sizes associated with psychiatric disorders. Among psychiatric disorder-susceptibility variants, rare variants with large effect sizes detected by sequencing anal...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Kimura H,Mori D,Aleksic B,Ozaki N

    更新日期:2020-12-11 00:00:00

  • Quantitative and temporal relationship between local cerebral blood flow and neuronal activation induced by somatosensory stimulation in rats.

    abstract::In many studies on functional neuroimaging, change in local cerebral blood flow induced by sensory stimulation (evoked LCBF) is used as a marker for change in cortical neuronal activity, although a full description of the relationship between the evoked LCBF and neuronal activity has not been given. The purpose of thi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Matsuura T,Kanno I

    更新日期:2001-07-01 00:00:00

  • Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity.

    abstract::Changes in levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in various regions of the rat brain following kainic acid-induced seizure activity were investigated. BDNF protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the in...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Katoh-Semba R,Takeuchi IK,Inaguma Y,Ito H,Kato K

    更新日期:1999-10-01 00:00:00

  • Menstrual and circadian variations in time perception in healthy women and women with premenstrual syndrome.

    abstract::A time production test was performed in seven normal females and seven females with premenstrual syndrome (PMS). We used a time production test for six time intervals (6, 12, 24, 36, 48, 60 s). Time production tests were performed at 08:00, 14:00 and 20:00 h in the follicular, early luteal and late luteal phases (LLP)...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Morofushi M,Shinohara K,Kimura F

    更新日期:2001-12-01 00:00:00

  • The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.

    abstract::TDP-43 pathology in motor neurons is a hallmark of ALS. In addition, the reduced expression of an RNA editing enzyme, adenosine deaminase acting on RNA 2 (ADAR2), increases the expression of GluA2 with an unedited Q/R site in the motor neurons of patients with sporadic ALS. As the occurrence of these two disease-speci...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Yamashita T,Hideyama T,Teramoto S,Kwak S

    更新日期:2012-06-01 00:00:00

  • Migration and differentiation of neural cell lines transplanted into mouse brains.

    abstract::In the past few years, the plasticity of the regional specification of the CNS has been widely debated on the results from in utero transplantation. Two different results are reported with this transplantation method. One is that the distribution of transplanted cells is dependent on the donor origin, and the other is...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Honda S,Toda K,Tozuka Y,Yasuzawa S,Iwabuchi K,Tomooka Y

    更新日期:2007-10-01 00:00:00

  • Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice.

    abstract::Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

    更新日期:2001-03-01 00:00:00

  • Functional correlation between olfaction and various sectioning of the lateral olfactory tract.

    abstract::The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sekiguchi Y,Fukushima N,Yokouchi K,Kawagishi K,Hirayama S,Moriizumi T

    更新日期:2012-05-01 00:00:00

  • Why context matters? Divisive normalization and canonical microcircuits in psychiatric disorders.

    abstract::Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie con...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Northoff G,Mushiake H

    更新日期:2020-07-01 00:00:00