Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.

abstract：:To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

journal_title：Neuroscience research

authors： Sawaguchi T

更新日期：2001-01-01 00:00:00

abstract：:To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

journal_title：Neuroscience research

authors： Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

更新日期：2005-05-01 00:00:00

abstract：:ATP-sensitive K(+) (K(ATP)) channel subunits SUR2A and SUR2B in the rat brain were investigated by RT-PCR assay, western blot analysis, in situ hybridization histochemistry, and immunohistochemical staining. The results show that the mRNA and protein of SUR2A and SUR2B are expressed in whole rat brain extracts and sel...

journal_title：Neuroscience research

authors： Zhou M,He HJ,Tanaka O,Sekiguchi M,Kawahara K,Abe H

更新日期：2012-10-01 00:00:00

abstract：:Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...

journal_title：Neuroscience research

authors： Meng P,Yoshida H,Tanji K,Matsumiya T,Xing F,Hayakari R,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Kawaguchi S,Imaizumi T

更新日期：2015-05-01 00:00:00

abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...

journal_title：Neuroscience research

authors： Im JY,Lee KW,Junn E,Mouradian MM

更新日期：2010-07-01 00:00:00

abstract：:Excitatory inputs to layer V neurons of the parasubiculum and medial entorhinal cortex were examined in rat brain slices with intracellular and field potential recordings. Single extracellular stimuli to layer V evoked subthreshold excitatory postsynaptic potentials (EPSPs) or a long duration (>100 ms) depolarization ...

journal_title：Neuroscience research

authors： Funahashi M,Matsuo R,Stewart M

更新日期：2002-01-01 00:00:00

abstract：:In this communication, I first summarize the mechanisms underlying human voluntary movements and define the involuntary movements (medical term). CLASSIFICATION OF HUMAN MOVEMENTS:Human movements are classified into two main kinds: intentional movements and non-intentional movements in which the involuntary movements...

journal_title：Neuroscience research

authors： Ugawa Y

更新日期：2020-07-01 00:00:00

abstract：:To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...

journal_title：Neuroscience research

authors： Hayashi R,Becker WJ,Lee RG

更新日期：1990-06-01 00:00:00

abstract：:To elucidate the molecular mechanisms that regulate the maturation of action potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in thi...

journal_title：Neuroscience research

authors： Wakazono Y,Kurahashi T,Nakahira K,Nagata I,Takayama C,Inoue Y,Kaneko A,Ikenaka K

更新日期：1997-12-01 00:00:00

abstract：:Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were...

journal_title：Neuroscience research

authors： Fujimoto K,Yoshida M,Ikeguchi K,Niijima K

更新日期：1989-04-01 00:00:00

abstract：:Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...

journal_title：Neuroscience research

authors： Ito Y,Honda A,Igarashi M

更新日期：2018-03-01 00:00:00

abstract：:Immunohistochemical staining for GD3 in adult rat brain was carried out using mouse IgM anti-GD3 monoclonal antibody (DSG-1). Neuronal cells in the cerebral cortex, striatum, hippocampus and various nuclei of the thalamus were immunoreactive. In the cerebellum, Purkinje cells, granule cells and also basket cells were ...

journal_title：Neuroscience research

authors： Kawai K,Mori M,Watarai S,Yasuda T

更新日期：1994-03-01 00:00:00

abstract：:Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...

journal_title：Neuroscience research

authors： Wixey JA,Reinebrant HE,Buller KM

更新日期：2012-07-01 00:00:00

abstract：:Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...

journal_title：Neuroscience research

authors： Koike T,Kan S,Misaki M,Miyauchi S

更新日期：2011-04-01 00:00:00

abstract：:In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps. In this work we have studied the binding of PRL in the male rat brain following morphine administration by both subcutaneo...

journal_title：Neuroscience research

authors： Lai Z,Zhai Q,Liu Z,Roos P,Nyberg F

更新日期：1995-10-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...

journal_title：Neuroscience research

authors： Mijangos-Moreno S,Poot-Aké A,Guzmán K,Arankowsky-Sandoval G,Arias-Carrión O,Zaldívar-Rae J,Sarro-Ramírez A,Murillo-Rodríguez E

更新日期：2016-04-01 00:00:00

abstract：:Neurons in the inferior temporal (IT) cortex respond not only to the shape, color or texture of objects, but to the horizontal positional disparity of visual features in the right and left retinal images. IT neurons with similar shape selectivity cluster in columns. In this study, we examined how IT neurons are spatia...

journal_title：Neuroscience research

authors： Yoshiyama K,Uka T,Tanaka H,Fujita I

更新日期：2004-02-01 00:00:00

abstract：:To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

journal_title：Neuroscience research

authors： Irie M,Nagata S,Endo Y

更新日期：2002-09-01 00:00:00

abstract：:Environmental factors during perinatal period have various effects on behavior. The present study examined the effects of prenatal stress and neonatal handling on anxiety and spatial learning of offspring. Prenatal stress increased anxiety-related behavior of adult offspring, whereas neonatal handling had no effect. I...

journal_title：Neuroscience research

authors： Akatsu S,Ishikawa C,Takemura K,Ohtani A,Shiga T

更新日期：2015-12-01 00:00:00

abstract：:Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...

journal_title：Neuroscience research

authors： Parker I,Gundersen CB,Miledi R

更新日期：1985-08-01 00:00:00

abstract：:Projection fields in the striatum and claustrum from eye movement-evoking cerebral cortices (EMECs) in the cat were investigated using the WGA-HRP tracing method under electrophysiological guidance to place WGA-HRP in the appropriate sites. The EMECs in the frontal cortex, which are located in the medial wall under th...

journal_title：Neuroscience research

authors： Miyashita E,Tamai Y

更新日期：1990-08-01 00:00:00

abstract：:We previously demonstrated that metabotropic glutamate receptor-subtype 1 knockout [mGluR1 (-/-)] mice showed ataxic gait, deficient long-term depression and impaired synapse elimination and these phenotypes were rescued by introduction of an mGluR1 transgene with Purkinje cell-specific promoter (mGluR1-rescue mice). ...

journal_title：Neuroscience research

authors： Nakao H,Nakao K,Kano M,Aiba A

更新日期：2007-04-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...

journal_title：Neuroscience research

authors： Wang YL,Liu W,Wada E,Murata M,Wada K,Kanazawa I

更新日期：2005-11-01 00:00:00

abstract：:Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

journal_title：Neuroscience research

authors： O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

更新日期：2010-02-01 00:00:00

abstract：:The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas d...

journal_title：Neuroscience research

authors： Fujii T,Okuda J,Tsukiura T,Ohtake H,Suzuki M,Kawashima R,Itoh M,Fukuda H,Yamadori A

更新日期：2002-12-01 00:00:00

abstract：:Adaptive changes in initial eye velocity of pursuit eye movement were examined in nine normal subjects using a target that moved in a multiple ramp fashion. Significant changes in initial eye velocity occurred rapidly after training in six of the subjects. The magnitude and direction of the induced changes were a func...

journal_title：Neuroscience research

authors： Fukushima K,Tanaka M,Suzuki Y,Fukushima J,Yoshida T

更新日期：1996-08-01 00:00:00

abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...

journal_title：Neuroscience research

authors： Otsu M,Sai T,Nakayama T,Murakami K,Inoue N

更新日期：2011-04-01 00:00:00

abstract：:Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Chicken Bsg (HT7/neurothelin/ 5A11) is expressed in neuroblasts, but disappears from neurons after a specific stage of cytodifferentiation, and becomes restrictedly expressed in the capillary endothelium in the adult brain. We s...

journal_title：Neuroscience research

authors： Fan QW,Yuasa S,Kuno N,Senda T,Kobayashi M,Muramatsu T,Kadomatsu K

更新日期：1998-01-01 00:00:00

abstract：:Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...

journal_title：Neuroscience research

authors： Salimi Z,Khajehpour L,Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2020-09-01 00:00:00

abstract：:Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

journal_title：Neuroscience research

authors： Takagi S,Obata K,Tsubokawa H

更新日期：2002-11-01 00:00:00