Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2).

abstract：:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...

journal_title：Neuroscience research

authors： Watanabe A,Kato N,Kato T

更新日期：2002-04-01 00:00:00

abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...

journal_title：Neuroscience research

authors： Kamiji NL,Yamamoto K,Hirasawa H,Yamada M,Usui S,Kurokawa M

更新日期：2012-04-01 00:00:00

abstract：:The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. H...

journal_title：Neuroscience research

authors： Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I

更新日期：2009-01-01 00:00:00

abstract：:We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...

journal_title：Neuroscience research

authors： Yamamoto S,Yamamoto M

更新日期：2006-06-01 00:00:00

abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

journal_title：Neuroscience research

authors： Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

更新日期：2020-06-01 00:00:00

abstract：:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

journal_title：Neuroscience research

authors： Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

更新日期：2002-02-01 00:00:00

abstract：:The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

journal_title：Neuroscience research

authors： Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

更新日期：2008-02-01 00:00:00

abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...

journal_title：Neuroscience research

authors： Kim DS,Yoo KY,Hwang IK,Jung JY,Won MH,Choi SY,Kwon OS,Seo JH,Kang TC

更新日期：2005-01-01 00:00:00

abstract：:In many studies on functional neuroimaging, change in local cerebral blood flow induced by sensory stimulation (evoked LCBF) is used as a marker for change in cortical neuronal activity, although a full description of the relationship between the evoked LCBF and neuronal activity has not been given. The purpose of thi...

journal_title：Neuroscience research

authors： Matsuura T,Kanno I

更新日期：2001-07-01 00:00:00

abstract：:In the mammalian central nervous system (CNS), transcription factor activator protein 2 (AP-2) is one of the critical regulatory factors for neural gene expression and neural development. As AP-2 has diverged into several subtypes, i.e. AP-2alpha, -2beta, and 2.2, we investigated the distribution of the AP-2 subtypes ...

journal_title：Neuroscience research

authors： Shimada M,Konishi Y,Ohkawa N,Ohtaka-Maruyama C,Hanaoka F,Makino Y,Tamura T

更新日期：1999-04-01 00:00:00

abstract：:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...

journal_title：Neuroscience research

authors： Monda M,Viggiano A,De Luca V

更新日期：2003-01-01 00:00:00

abstract：:Area TE sends dense projections to the perirhinal cortex in macaque monkeys, an area in which we previously observed flexible signals regarding upcoming reward outcomes during a conditional-association cued-reward task. To investigate neuronal processing during the generation of information on upcoming reward outcomes...

journal_title：Neuroscience research

authors： Ohyama K,Sugase-Miyamoto Y,Matsumoto N,Sato C,Shidara M

更新日期：2014-11-01 00:00:00

abstract：:The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...

journal_title：Neuroscience research

authors： Abdin AA,Sarhan NI

更新日期：2011-12-01 00:00:00

abstract：:POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...

journal_title：Neuroscience research

authors： Korutla L,Neustadter JH,Fournier KM,Mackler SA

更新日期：2003-05-01 00:00:00

abstract：:Stroke is a common cause of death and severe disability among adults in developed countries. Cigarette smoking adversely affects human health in many ways and is considered to be a risk factor for a stroke. However, the mechanism that determines the relative importance of neurotrophins in this process remains unclear....

journal_title：Neuroscience research

authors： Yang JT,Chang CN,Wu JH,Chung CY,Weng HH,Cheng WC,Lee TH

更新日期：2008-04-01 00:00:00

abstract：:A multibarreled glass-coated tungsten microelectrode suitable for single-unit recording and iontophoresis in chronically behaving animals is described. The microelectrode was stiff enough to pass through the dura matter of behaving monkeys, and can be applied as a microiontophoretic electrode. The electrode is easy to...

journal_title：Neuroscience research

authors： Li BM,Mei ZT,Kubota K

更新日期：1990-07-01 00:00:00

abstract：:To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

journal_title：Neuroscience research

authors： Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

更新日期：2005-05-01 00:00:00

abstract：:Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...

journal_title：Neuroscience research

authors： Smit AE,Buisseret P,Buisseret-Delmas C,De Zeeuw CI,VanderWerf F,Zerari-Mailly F

更新日期：2006-12-01 00:00:00

abstract：:The adult human brain appears to have specialized and independent neural systems for the visual processing of faces and words: greater selectivity for faces in the right hemisphere (RH) while greater selectivity for words in the left hemisphere (LH). Nevertheless, the nature of functional differences between the hemis...

journal_title：Neuroscience research

authors： Inamizu S,Yamada E,Ogata K,Uehara T,Kira JI,Tobimatsu S

更新日期：2020-07-01 00:00:00

abstract：:Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investig...

journal_title：Neuroscience research

authors： Schomburg ED,Steffens H,Pilyavskii AI,Maisky VA,Brück W,Dibaj P,Sears TA

更新日期：2015-06-01 00:00:00

abstract：:Event-related potentials (ERPs) during an auditory discrimination task were recorded both on the surface and at a depth of the auditory cortex in rats. Ten-kilohertz rare and 5-kHz frequent tones were used with the probabilities of 0.2 and 0.8. Lever pressing within 2 s, following the onset of the rare tone, was rewar...

journal_title：Neuroscience research

authors： Iwanami A,Shinba T,Sumi M,Ozawa N,Yamamoto K

更新日期：1994-11-01 00:00:00

abstract：:Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). CO is generated by heme oxygenase during the conversion of heme to biliverdin. In this study, we raised an antiserum against the ...

journal_title：Neuroscience research

authors： Yamanaka M,Yamabe K,Saitoh Y,Katoh-Semba R,Semba R

更新日期：1996-03-01 00:00:00

abstract：:Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...

journal_title：Neuroscience research

authors： Kanazawa I,Ogawa T,Kimura S,Munekata E

更新日期：1984-12-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...

journal_title：Neuroscience research

authors： Kim JH,Park M,Yang SY,Jeong BS,Yoo HJ,Kim JW,Chung JH,Kim SA

更新日期：2006-10-01 00:00:00

abstract：:After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...

journal_title：Neuroscience research

authors： Funakoshi K,Kusakabe T,Kadota T,Goris RC,Kishida R

更新日期：1989-12-01 00:00:00

abstract：:Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a granular tau oligomer having a pre-filamentous structure. To determine the role of this oligomer in NFT formation, we quantified the amount of gr...

journal_title：Neuroscience research

authors： Maeda S,Sahara N,Saito Y,Murayama S,Ikai A,Takashima A

更新日期：2006-03-01 00:00:00

abstract：:Accumulating evidence demonstrates astrocytic crucial roles in the brain, but the molecular basis underlying astrocytic intracellular protein trafficking remains to be elucidated. The present study reports the identification of novel protein, brain-derived integrating factor-1 (BDIF1), which comprises TBC (Tre-2/Bub2/...

journal_title：Neuroscience research

authors： Ito T,Ueki T,Furukawa H,Sato K

更新日期：2011-07-01 00:00:00

abstract：:We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...

journal_title：Neuroscience research

authors： Wakusawa K,Sugiura M,Sassa Y,Jeong H,Yomogida Y,Horie K,Sato S,Yokoyama H,Kure S,Takei N,Mori N,Kawashima R

更新日期：2015-01-01 00:00:00

abstract：:The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...

journal_title：Neuroscience research

authors： Bäck N,Tyynelä M,Portier MM,Virtanen I,Soinila S

更新日期：1995-06-01 00:00:00

abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...

journal_title：Neuroscience research

authors： Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

更新日期：2002-08-01 00:00:00