Abstract:
:The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontophoretic ejection of 1S,3R-ACPD. The effect of 1S,3R-ACPD depended on both the strength and the duration of the iontophoretic current. Application of the agonist with ejection currents at or slightly above the response threshold for up to 60 s resulted in an increased rate of action potential firing. With larger ejection currents of the same duration the initial increase in activity was followed by a depression and eventually a cessation of activity. In the transition phase between low frequency firing and firing arrest, Purkinje cells generated almost exclusively complex spikes. When the drug application was continued for longer durations (1-10 min) the initial response was followed by a characteristic cyclic firing pattern. These cycles consisted of alternating phases of mainly simple spike activity, predominantly complex spike activity and silent intervals. At the end of drug applications using large ejection currents, a prolonged period (on average 66 s) with almost no spiking activity was observed. This period ended with an abrupt onset of simple spike firing. These findings point to an important function of cerebellar metabotropic glutamate receptors in the regulation of Purkinje cell activity.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Lingenhöhl K,Knöpfel T,Olpe HRdoi
10.1016/0168-0102(93)90057-wsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
223-8issue
3eissn
0168-0102issn
1872-8111pii
0168-0102(93)90057-Wjournal_volume
18pub_type
杂志文章abstract::The role of GABA in medial preoptico-anterior hypothalamic area in the regulation of spontaneous sleep-wakefulness and rapid eye movement sleep was investigated in this study. Local microinjection of picrotoxin, a GABA-A antagonist, into this area increased quiet wakefulness but significantly reduced deep sleep and ra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(99)00013-9
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journal_title:Neuroscience research
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pub_type: 杂志文章
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journal_title:Neuroscience research
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00979-5
更新日期:1995-12-01 00:00:00
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更新日期:2012-05-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章,评审
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更新日期:1991-10-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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更新日期:2020-02-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.06.1467
更新日期:2007-10-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.01.003
更新日期:2009-04-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.07.001
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pub_type: 杂志文章
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journal_title:Neuroscience research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-02-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.02.010
更新日期:2006-06-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.01.003
更新日期:2017-06-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2011.11.002
更新日期:2012-02-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.07.007
更新日期:2014-01-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90033-b
更新日期:1990-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90073-l
更新日期:1992-09-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.02.001
更新日期:2015-06-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00897-2
更新日期:1995-05-01 00:00:00