Abstract：
:Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential link between psychological and biological processes. Considering that withdrawal initiates a widespread activation of cortical regions responsible for compulsive drug seeking and desire for the drug, we predict that withdrawal would result in a significant increase in functional cortical connectivity. We applied the novel operational architectonics approach that enables us to estimate both local and remote functional cortical connectivity by means of EEG structural synchrony measure. In 13 withdrawal opioid-dependent patients we found the evidence that local and remote cortical functional connectivity was indeed significantly enhanced (for both alpha and beta frequency oscillations). Additionally, statistical relationship between functional connectivity and the severity of opioid withdrawal has been found.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Fingelkurts AA,Fingelkurts AA,Kivisaari R,Autti T,Borisov S,Puuskari V,Jokela O,Kähkönen Sdoi
10.1016/j.neures.2007.01.011subject
Has Abstractpub_date
2007-05-01 00:00:00pages
40-9issue
1eissn
0168-0102issn
1872-8111pii
S0168-0102(07)00051-Xjournal_volume
58pub_type
杂志文章abstract：:[3H]Glutamic acid binding to hippocampi was increased after amygdaloid kindling in rats, and diazepam inhibited this increased binding, without any effect on the enhanced binding by CaCl2 or the binding in control rats. By inducing kindling in the same way as that used in the binding experiment, the inhibiting effects...
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abstract：:Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...
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abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.11.007
更新日期：2007-03-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00033-9
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.01.011
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abstract：:Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...
journal_title：Neuroscience research
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doi：10.1016/j.neures.2018.05.007
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pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00107-8
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90048-j
更新日期：1990-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.07.007
更新日期：2019-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01024-3
更新日期：1996-05-01 00:00:00
abstract：:In our previous study using the whole-cell patch clamp technique combined with reverse transcription-polymerase chain reaction analysis in rat brainstem slices, we demonstrated that the classification of neurons in the medial vestibular nucleus (MVN) based on three membrane properties detected as voltage response prop...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.06.1479
更新日期：2007-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.05.009
更新日期：2006-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00130-2
更新日期：1998-03-01 00:00:00
abstract：:Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2012-02-01 00:00:00
abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.12.003
更新日期：2004-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0168-0102(84)90009-9
更新日期：1984-12-01 00:00:00
abstract：:Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the β- and γ-secretases generates Aβ peptides; however, the alternate cleavage of APP by the α- and γ-secretases decreases Aβ production. We previously reported th...
journal_title：Neuroscience research
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更新日期：2014-02-01 00:00:00
abstract：:The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.011
更新日期：2020-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2016.09.010
更新日期：2017-03-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.01.005
更新日期：2005-05-01 00:00:00
abstract：:The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90163-5
更新日期：1994-01-01 00:00:00
abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.09.007
更新日期：2008-01-01 00:00:00
abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00216-4
更新日期：2001-06-01 00:00:00
abstract：:Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for the maternal immune activation background in patients with neurodevelopmental disorders h...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.07.003
更新日期：2016-12-01 00:00:00
abstract：:Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the n...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00184-6
更新日期：2003-10-01 00:00:00
