Abstract:
:The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spike at 0.3-1 microM and at 10 microM respectively. At these doses neither of these drugs did affect the amplitude of the population spike (PSA) evoked by test stimuli in the absence of tetanic stimulation. The attenuating effect of mCPBG on LTP was reversed by the GABAA receptor antagonist bicuculline. On the other hand, 5-HT3 receptor antagonists ondansetron and granisetron significantly augmented the magnitude of LTP at 1-3 microM and at 0.1-0.3 microM, respectively, without changes in PSA before tetanus. The augmenting effect of granisetron on LTP was partially but significantly reversed by the muscarinic receptor antagonist atropine. These findings suggest that the induction of the LTP in the mossy fiber-CA3 system is inhibited by an activation of 5-HT3 receptors through the facilitation of GABAergic neurons (GABAA receptors) and the inhibition of cholinergic neurons (muscarinic receptors).
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Maeda T,Kaneko S,Satoh Mdoi
10.1016/0168-0102(94)90163-5subject
Has Abstractpub_date
1994-01-01 00:00:00pages
277-82issue
4eissn
0168-0102issn
1872-8111pii
0168-0102(94)90163-5journal_volume
18pub_type
杂志文章abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.01.005
更新日期:2005-05-01 00:00:00
abstract::The purposes of the present study were to determine which upper airway movements cause a difference in the expiratory airflow pathway between sneezing and coughing, and to develop a new animal model for studying the neural mechanism of sneezing in paralyzed animals, i.e. fictive sneezing. We compared the upper airway ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00075-3
更新日期:1998-10-01 00:00:00
abstract::This paper describes for the first time the phenomenon of spatio-temporal mapping of interchannel temporal coincidences of rapid transition processes (RTPs) in multiple EEG frequencies. It is suggested that RTPs in multiple EEG frequencies found in different EEG channels could reflect the process of switching between ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.07.2031
更新日期:2010-11-01 00:00:00
abstract::Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00911-c
更新日期:1995-07-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00025-1
更新日期:2002-06-01 00:00:00
abstract::The adult human brain appears to have specialized and independent neural systems for the visual processing of faces and words: greater selectivity for faces in the right hemisphere (RH) while greater selectivity for words in the left hemisphere (LH). Nevertheless, the nature of functional differences between the hemis...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.11.006
更新日期:2020-07-01 00:00:00
abstract::In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.09.007
更新日期:2008-01-01 00:00:00
abstract::To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00204-2
更新日期:2001-01-01 00:00:00
abstract::Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.08.005
更新日期:2006-12-01 00:00:00
abstract::To study the differences between peripheral nerve (PN) and embryonic homologous CNS structures as a conduit for CNS axons, spinal cord segments in neonatal rats were removed at the mid-thoracic level and PN or embryonic spinal cord (ESC) segments were grafted into the vacancy. Neural connections across the graft were ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00042-x
更新日期:1998-07-01 00:00:00
abstract::Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90024-2
更新日期:1989-04-01 00:00:00
abstract::In 15 cats with implantations of crystalline HRP-WGA in the cerebellar nuclei and tetramethylbenzidine histochemistry, the pontine nuclei were carefully examined for presence of retrogradely labelled cells. Findings in the nucleus reticularis tegmenti pontis and the inferior olive, both known to project to the cerebel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90013-1
更新日期:1986-11-01 00:00:00
abstract::Long-term depression at parallel fiber-Purkinje cell synapses plays a principal role in learning in the cerebellum, which acts as a supervised learning machine. Recent experiments demonstrate various forms of synaptic plasticity at different sites within the cerebellum. In this article, we take into consideration syna...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2019.03.001
更新日期:2019-11-01 00:00:00
abstract::Narcolepsy is a chronic sleep disorder marked by excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Since the discovery of sleep onset REM periods (SOREMPs) in narcoleptic patients, narcolepsy has often been regarded as a disorder of REM sleep generation: REM sleep intrudes in act...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00195-4
更新日期:2000-12-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.11.012
更新日期:2018-01-01 00:00:00
abstract::GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01102-9
更新日期:1996-10-01 00:00:00
abstract::The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00063-9
更新日期:2002-08-01 00:00:00
abstract::In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(96)01060-7
更新日期:1996-07-01 00:00:00
abstract::Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.03.014
更新日期:2013-08-01 00:00:00
abstract::Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.04.003
更新日期:2007-07-01 00:00:00
abstract::The pattern of distribution of cholinergic fibers was examined immunohistochemically in the cat superior colliculus by using a monoclonal antibody against choline acetyltransferase (ChAT). In the superficial layers, an obvious immunoreactive zone was found in the rostral two-thirds of the outer portion of the superfic...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90004-7
更新日期:1989-06-01 00:00:00
abstract::The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the respo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.09.001
更新日期:2013-11-01 00:00:00
abstract::Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00034-5
更新日期:1997-06-01 00:00:00
abstract::In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90066-8
更新日期:1991-06-01 00:00:00
abstract::The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00160-8
更新日期:2002-12-01 00:00:00
abstract::Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for the maternal immune activation background in patients with neurodevelopmental disorders h...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2016.07.003
更新日期:2016-12-01 00:00:00
abstract::Maternal stress, viral infection, and obstetric complications, which trigger cytokine signaling, are hypothesized to be involved in schizophrenia and its related disorders. The etiologic contribution of individual cytokines to such psychiatric disorders, however, remains to be evaluated. To estimate the impact of peri...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.05.010
更新日期:2004-09-01 00:00:00
abstract::Confocal laser scanning microscopy (CLSM) was used to record spatial and dynamic changes in the intracellular Ca2+ [(Ca2+]i) of bullfrog sympathetic ganglion cells in excised tissue or in culture. A CLSM utilizing Ar ion laser (488 nm) and recording fluo-3 fluorescence yielded the sliced image of ganglion cells, while...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90082-a
更新日期:1991-05-01 00:00:00
abstract::Recent rapid progress in genome analysis and large-scale consortia has made it possible to discover variants with a variety of allele frequencies and effect sizes associated with psychiatric disorders. Among psychiatric disorder-susceptibility variants, rare variants with large effect sizes detected by sequencing anal...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2020.11.008
更新日期:2020-12-11 00:00:00
abstract::In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.02.002
更新日期:2009-05-01 00:00:00