Abstract:
:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was given. At 15 and 35 weeks post-treatment, the number of choline acetyltransferase (ChAT)-positive neurons in the nucleus of the diagonal band/medial septal nucleus (NDB/MS) was significantly smaller in the molar crown-less group than in the control group (P < 0.01). This was not the case in the pedunculopontine tegmental nucleus or (PPT) or in the trigeminal motor nucleus. Biochemical assay showed no statistically significant differences in choline concentrations in the hippocampus between the control and the molar crown-less group both at 15 and at 35 weeks post-treatment. Nevertheless, acetylcholine (ACh) concentration in the hippocampus of the molar crown-less group was significantly lower than that of the control group at 15 weeks post-treatment (P < 0.05). Taken together, a decrease of oral sensory information may have caused a reduction in the number of ChAT-positive neurons selectively in NDB/MS, which in turn caused a decline of ACh concentrations in the hippocampus.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami Mdoi
10.1016/s0168-0102(02)00063-9subject
Has Abstractpub_date
2002-08-01 00:00:00pages
373-9issue
4eissn
0168-0102issn
1872-8111pii
S0168010202000639journal_volume
43pub_type
杂志文章abstract::Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.10.002
更新日期:2018-08-01 00:00:00
abstract::The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00208-0
更新日期:2003-02-01 00:00:00
abstract::Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(01)00209-7
更新日期:2001-05-01 00:00:00
abstract::A significant activity of [3H]glutamate binding was detected in homogenate particulate preparations obtained from the rat pituitary, in addition to central structures including the cerebral cortex. In contrast to the cerebral binding, the pituitary binding was significantly inhibited by Na+ ions. It was also found tha...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90034-9
更新日期:1986-07-01 00:00:00
abstract::Narcolepsy is a chronic sleep disorder marked by excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Since the discovery of sleep onset REM periods (SOREMPs) in narcoleptic patients, narcolepsy has often been regarded as a disorder of REM sleep generation: REM sleep intrudes in act...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00195-4
更新日期:2000-12-01 00:00:00
abstract::After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90018-7
更新日期:1989-12-01 00:00:00
abstract::A multibarreled glass-coated tungsten microelectrode suitable for single-unit recording and iontophoresis in chronically behaving animals is described. The microelectrode was stiff enough to pass through the dura matter of behaving monkeys, and can be applied as a microiontophoretic electrode. The electrode is easy to...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90023-8
更新日期:1990-07-01 00:00:00
abstract::The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.011
更新日期:2020-01-01 00:00:00
abstract::The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90020-9
更新日期:1986-05-01 00:00:00
abstract::The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.02.002
更新日期:2007-05-01 00:00:00
abstract::In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.02.002
更新日期:2009-05-01 00:00:00
abstract::In our previous study using the whole-cell patch clamp technique combined with reverse transcription-polymerase chain reaction analysis in rat brainstem slices, we demonstrated that the classification of neurons in the medial vestibular nucleus (MVN) based on three membrane properties detected as voltage response prop...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.06.1479
更新日期:2007-10-01 00:00:00
abstract::It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.04.004
更新日期:2004-08-01 00:00:00
abstract::Electrical stimulation could enhance nerve regeneration and functional recovery. The objective of this study was to evaluate the regenerative effects of implanted electrodes with different contacts in resected sciatic nerve. Sciatic nerve resection and microsurgical repair models were established and randomly divided ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2018.08.007
更新日期:2019-08-01 00:00:00
abstract::Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00012-9
更新日期:2003-04-01 00:00:00
abstract::Although neuromuscular blocking agents (NMBAs) function as muscular nicotinic acetylcholine receptor (nAChR) antagonists, several studies have shown that they block neuronal nAChRs as well, which led us to hypothesize that these agents can affect neuronal nAChRs expressed in respiratory centers. To test this hypothesi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00213-x
更新日期:2003-11-01 00:00:00
abstract::Effective connectivity analysis has been widely applied to noninvasive recordings such as functional magnetic resonance imaging and electroencephalograms (EEGs). Previous studies have aimed to extract the causal relations between brain regions, but the validity of the derived connectivity has not yet been fully determ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.09.003
更新日期:2020-07-01 00:00:00
abstract::Our previous research suggested that the P2X4 receptor (P2X4R) expression in microglia was involved in the activation of toll-like receptor-4 (TLR4) in the dorsal horn in the rat model of cancer induced bone pain (CIBP). In this study, we focused on whether TLR4- mitogen-activated protein kinases, p38 (p38 MAPK) contr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.06.006
更新日期:2017-12-01 00:00:00
abstract::Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.02.004
更新日期:2020-02-01 00:00:00
abstract::Afferent neurons entering the central nervous systems of vertebrates and invertebrates receive presynaptic inhibition on their axon terminals. This usually involves an increase in membrane conductance (shunting) and depolarization (primary afferent depolarization, PAD). In arachnids and crustaceans the peripherally lo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::Using a confocal laser scanning microscope (CLSM) and an electron microscope, we investigated the organization of the main olfactory bulb (MOB) of tenrecs, which were previously included into insectivores but now considered to be in a new order "Afrosoricida" in the superclade 'Afrotheria'. We confirmed that the overa...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.08.004
更新日期:2005-12-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.02.001
更新日期:2015-06-01 00:00:00
abstract::Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.07.002
更新日期:2014-01-01 00:00:00
abstract::The purposes of the present study were to determine which upper airway movements cause a difference in the expiratory airflow pathway between sneezing and coughing, and to develop a new animal model for studying the neural mechanism of sneezing in paralyzed animals, i.e. fictive sneezing. We compared the upper airway ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00075-3
更新日期:1998-10-01 00:00:00
abstract::Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.11.011
更新日期:2008-03-01 00:00:00
abstract::Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90021-3
更新日期:1994-07-01 00:00:00
abstract::This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00191-8
更新日期:2003-01-01 00:00:00
abstract::Pathological gambling (PG) is a non-substance based addiction that shares many behavioral and neural features with substance based addictions. However, in PG behavioral and neural changes are unlikely to be confounded by effects of acute or chronic drug exposure. Changes in reward based decision-making in particular i...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2014.09.008
更新日期:2015-01-01 00:00:00
abstract::NAP-22, a neuronal tissue-enriched acidic membrane protein, is a Ca(2+)-dependent calmodulin binding protein and has similar biochemical characteristics to GAP-43 (neuromodulin). Recent biochemical studies have demonstrated that NAP-22 localizes in the membrane raft domain with a cholesterol-dependent manner. Since th...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00132-2
更新日期:2000-08-01 00:00:00
abstract::The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.02.006
更新日期:2012-05-01 00:00:00