Abstract：
:Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the sensitivity to a late-coming trauma. Using a mouse PTSD model, we found that a prior foot shock enhances contextual fear conditioning. This shock-induced facilitation of fear conditioning (i.e., priming effect) persisted for 7 days and was prevented by MK801, an N-methyl-D-aspartate receptor antagonist. Other types of trauma, such as forced swimming or tail pinch, did not induce a priming effect on fear conditioning. Thus, a trauma is unlikely generalized to modify the sensitivity to other traumatic experiences. The behavioral procedure employed in this study may be a useful tool to elucidate the etiology of PTSD.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Iwasaki S,Sakaguchi T,Ikegaya Ydoi
10.1016/j.neures.2015.02.001subject
Has Abstractpub_date
2015-06-01 00:00:00pages
66-73eissn
0168-0102issn
1872-8111pii
S0168-0102(15)00035-8journal_volume
95pub_type
杂志文章abstract：:The critical flicker-fusion frequency (CFF), defined as the frequency at which a flickering light is indistinguishable from a continuous light, is a useful measure of visual temporal resolution. The mouse CFF has been studied by electrophysiological approaches such as recordings of the electroretinogram (ERG) and the ...
journal_title：Neuroscience research
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pub_type： 杂志文章,评审
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.008
更新日期：2019-12-01 00:00:00
abstract：:We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...
journal_title：Neuroscience research
pub_type： 杂志文章
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