Abstract:
:Zinc is one of trace elements that play essential roles in several cell functions, and is unquestionably important to the normal health and function of the central nervous system. Growing evidence suggests that Zn(2+) can become a pathogenic agent in certain neurological disease states, such as ischemia, seizures, and trauma. The main role of the Zn(2+) may serve as an endogenous neuromodulator in the brain. In the present study, we used the electrophysiology method to investigate the effects of Zn(2+) on the excitability of hippocampus CA1 region. Our results have demonstrated that the Zn(2+) activates the Wistar rat hippocampal CA1 region network by significantly enhancing the spike rate of the spontaneous firing. In addition, Zn(2+) can increase the intrinsic membrane excitability by enhancing the firing rate and half-width of the evoked action potential. Meanwhile, our results also indicate that Zn(2+) can effectively inhibit voltage-dependent potassium currents (both transient outward potassium currents and delayed rectifier potassium currents). On the other hand, Zn(2+) also inhibits excitatory neurotransmitter release by decreasing the inter-event interval and the total charge transfer of the excitatory postsynaptic currents. The present results, in combination with other works, suggest that Zn(2+) can influence neuronal excitability, intrinsic membrane excitability and synaptic transmission in the hippocampus CA1 neurons by multiple mechanisms.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Tian Y,Yang Z,Zhang Tdoi
10.1016/j.neures.2010.07.2030subject
Has Abstractpub_date
2010-11-01 00:00:00pages
167-75issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(10)02215-7journal_volume
68pub_type
杂志文章abstract::Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.11.002
更新日期:2018-03-01 00:00:00
abstract::The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00288-7
更新日期:2001-11-01 00:00:00
abstract::The effect of synthetic spider toxin analogs containing aza-crown in combination with zinc and copper was studied on the lobster neuromuscular synapse. The suppressive action of N4-type spider toxin analog (N4) on excitatory postsynaptic potentials (EPSPs) was markedly enhanced in the presence of 10(-5)-10(-4) M Zn2+....
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90028-x
更新日期:1989-04-01 00:00:00
abstract::Effects of 1-naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors were studied in cultured rat hippocampal neurons using the whole-cell patch clamp technique. A population of cultured neurons had ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00067-9
更新日期:1997-09-01 00:00:00
abstract::Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.10.006
更新日期:2018-08-01 00:00:00
abstract::Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervic...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(88)90014-4
更新日期:1988-12-01 00:00:00
abstract::Electrical stimulation could enhance nerve regeneration and functional recovery. The objective of this study was to evaluate the regenerative effects of implanted electrodes with different contacts in resected sciatic nerve. Sciatic nerve resection and microsurgical repair models were established and randomly divided ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2018.08.007
更新日期:2019-08-01 00:00:00
abstract::The coexistence of varying combinations of substance P (SP), somatostatin (SOM), thyrotropin-releasing hormone (TRH) and met-enkephalin-Arg-Gly-Leu (ENK) with 5-hydroxytryptamine (5-HT) as semiquantitatively revealed by immunocytochemistry in neuronal perikarya of the raphe pallidus et obscurus in the guinea-pig was a...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90033-3
更新日期:1989-10-01 00:00:00
abstract::POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00024-5
更新日期:2003-05-01 00:00:00
abstract::In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps. In this work we have studied the binding of PRL in the male rat brain following morphine administration by both subcutaneo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00953-1
更新日期:1995-10-01 00:00:00
abstract::Our previous research suggested that the P2X4 receptor (P2X4R) expression in microglia was involved in the activation of toll-like receptor-4 (TLR4) in the dorsal horn in the rat model of cancer induced bone pain (CIBP). In this study, we focused on whether TLR4- mitogen-activated protein kinases, p38 (p38 MAPK) contr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.06.006
更新日期:2017-12-01 00:00:00
abstract::Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the β- and γ-secretases generates Aβ peptides; however, the alternate cleavage of APP by the α- and γ-secretases decreases Aβ production. We previously reported th...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.11.004
更新日期:2014-02-01 00:00:00
abstract::GABAergic characteristics of transcallosal activity of cat pyramidal tract neurons (PTNs) and non-PTNs (nPTNs) were studied with stressing on GABAB receptors. PTNs and nPTNs were further classified into group 1 (< 10 ms) and group 2 (> 10 ms) based on the latency upon transcallosal stimulation. However, mainly the res...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01112-1
更新日期:1996-12-01 00:00:00
abstract::It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.01.008
更新日期:2012-04-01 00:00:00
abstract::The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.10.009
更新日期:2008-02-01 00:00:00
abstract::Temporal changes in kainate-induced seizure activity and hippocampal NO generation were evaluated simultaneously in conscious rats by using in vivo microdialysis and by determining the concentrations of nitrite and nitrate in perfusates. Intraperitoneal injection of kainic acid produced 'wet dog shake', focal seizure ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00086-8
更新日期:1998-11-01 00:00:00
abstract::In the mammalian central nervous system (CNS), transcription factor activator protein 2 (AP-2) is one of the critical regulatory factors for neural gene expression and neural development. As AP-2 has diverged into several subtypes, i.e. AP-2alpha, -2beta, and 2.2, we investigated the distribution of the AP-2 subtypes ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(99)00017-6
更新日期:1999-04-01 00:00:00
abstract::In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.01.004
更新日期:2017-06-01 00:00:00
abstract::The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.09.007
更新日期:2006-12-01 00:00:00
abstract::Accumulating evidence demonstrates astrocytic crucial roles in the brain, but the molecular basis underlying astrocytic intracellular protein trafficking remains to be elucidated. The present study reports the identification of novel protein, brain-derived integrating factor-1 (BDIF1), which comprises TBC (Tre-2/Bub2/...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.03.008
更新日期:2011-07-01 00:00:00
abstract::Experiments were performed to study the projection of the group y of the vestibular nuclei and the dentate and fastigial nuclei of the cerebellum to the interstitial nucleus of Cajal (INC) in cats by using retrograde axonal transport of horseradish peroxidase (HRP) and electrophysiological methods; and to study the ve...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90021-0
更新日期:1986-05-01 00:00:00
abstract::We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.01.007
更新日期:2008-05-01 00:00:00
abstract::It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.04.004
更新日期:2004-08-01 00:00:00
abstract::Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90047-7
更新日期:1994-05-01 00:00:00
abstract::To investigate how motor programs can be modified by sensory inputs we recorded kinematic and EMG patterns from normal human subjects performing well-practised wrist flexion movements in response to an auditory tone. On random trials unexpected wrist perturbations were introduced at varying times after the signal to m...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90062-j
更新日期:1990-06-01 00:00:00
abstract::The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.12.020
更新日期:2011-04-01 00:00:00
abstract::In an attempt to test the possibility that sino-aortic baroreceptors may mediate the previously reported stress response in hypothalamic magnocellular neurosecretory cell activity in rats, effects of deafferentation of sino-aortic baroreceptors on plasma levels of vasopressin and oxytocin after fear-related emotional ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90059-l
更新日期:1992-04-01 00:00:00
abstract::We excised the dorsal part of the optic vesicle of chick embryos at stages 13-14 (embryonic day 2). The remainder of the optic vesicle reoganized and developed a small eye. This study was undertaken to determine how locus specificity is kept within the reorganized retina. The projection pattern from the reorganized ey...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90022-5
更新日期:1992-10-01 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.06.013
更新日期:2006-10-01 00:00:00
abstract::Fifteen rabbits were classically conditioned using stimulation of the right pontine nuclei as a conditioned stimulus and a corneal airpuff as an unconditioned stimulus. After conditioning criterion was reached, the stimulation conditioned stimulus was transferred to the left pontine nuclei and the rate of conditioned ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90057-x
更新日期:1986-09-01 00:00:00