Abstract:
:Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subspecies, which is expressed ubiquitously in many tissues, showed no significant difference among tissue areas tested. Unlike other subspecies, the delta-subspecies was primarily associated with particulate fractions. Subcellular fractionation analysis revealed that both the epsilon- and delta-subspecies were enriched in the synaptosomal P2 fraction. Treatment with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) induced translocation of the epsilon-subspecies from cytosolic fraction to membrane fraction. In contrast, upon treatment with TPA, the delta-subspecies normally bound to membrane fraction was released into cytosol.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Matsushima S,Nakamura Sdoi
10.1016/0168-0102(94)90047-7subject
Has Abstractpub_date
1994-05-01 00:00:00pages
339-43issue
3eissn
0168-0102issn
1872-8111pii
0168-0102(94)90047-7journal_volume
19pub_type
杂志文章abstract::Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.10.006
更新日期:2018-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(01)00253-x
更新日期:2001-07-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.009
更新日期:2020-01-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.02.001
更新日期:2015-06-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00026-1
更新日期:1998-05-01 00:00:00
abstract::Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(84)90009-9
更新日期:1984-12-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90105-y
更新日期:1993-10-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00245-0
更新日期:2001-08-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.01.001
更新日期:2006-05-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2014.09.008
更新日期:2015-01-01 00:00:00
abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.12.013
更新日期:2010-04-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.02.005
更新日期:2010-06-01 00:00:00
abstract::Neurons in the inferior temporal (IT) cortex respond not only to the shape, color or texture of objects, but to the horizontal positional disparity of visual features in the right and left retinal images. IT neurons with similar shape selectivity cluster in columns. In this study, we examined how IT neurons are spatia...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2003.10.008
更新日期:2004-02-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00059-2
更新日期:2003-06-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.12.005
更新日期:2010-04-01 00:00:00
abstract::The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90020-9
更新日期:1986-05-01 00:00:00
abstract::T-type Ca2+ channel-dependent long-term potentiation (LTP) occurs predominantly during the critical period of ocular dominance plasticity in rat and cat visual cortex. Noradrenaline and serotonin are known to facilitate ocular dominance plasticity. In this study using rat visual cortical slices, we tested whether this...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.02.014
更新日期:2009-06-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopamine (DA) system. Although previous studies have shown that pretreatment with GDNF could prevent degenerative changes of nigrostriatal DA system ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(00)00097-3
更新日期:2000-04-01 00:00:00
abstract::The purpose of this study was to investigate electrophysiological correlates related to the recognition of repeated faces in the intact human by means of event-related brain potentials (ERPs). A group of young healthy adults performed a continuous face recognition task, in which 240 unfamiliar faces were flashed upon ...
journal_title:Neuroscience research
pub_type: 临床试验,杂志文章
doi:10.1016/s0168-0102(97)00047-3
更新日期:1997-07-01 00:00:00
abstract::Eye movements were induced by stimulating the ventral bank of the anterior ectosylvian sulcus (AES) of chloralose-anesthetized cats. Intracortical microstimulation of this cortex evoked centering movements of both eyes. The latency of eye movement was 45 ms (range 40-60 ms) and the intensity of stimulation was 33 micr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90056-4
更新日期:1989-11-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00036-6
更新日期:2002-07-01 00:00:00
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journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01133-9
更新日期:1997-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.11.012
更新日期:2018-01-01 00:00:00
abstract::Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.07.002
更新日期:2014-01-01 00:00:00
abstract::The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-prol...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90042-w
更新日期:1991-08-01 00:00:00
abstract::It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(87)90023-x
更新日期:1987-10-01 00:00:00
abstract::Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00185-8
更新日期:2003-09-01 00:00:00
abstract::Although the rat has been the predominant rodent used to investigate the pathophysiology and treatment of experimental spinal cord injury (SCI), the increasing availability of transgenic animals has led to greater use of mouse models. However, behavioral assessment after SCI in mice has been less extensively investiga...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.02.009
更新日期:2010-06-01 00:00:00
abstract::Neuropathic pain is a very complex chronic pain state, the detailed molecular mechanisms of which remain unclear. In the present study, Shank3 was found to play an important role in neuropathic pain in rats following spared nerve injury (SNI). Shank3 was upregulated in the spinal dorsal horn of rats subjected to SNI, ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2020.05.010
更新日期:2020-05-23 00:00:00
abstract::Spinal cord injury (SCI) is a serious condition often affecting young and healthy individuals around the world. Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in SCI, but the underlying mechanism remains largely unknown especially regarding neural specific proteins ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.04.012
更新日期:2010-08-01 00:00:00