Abstract：
:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine showed an increase on malondialdehyde equivalents (MDA) in the prefrontal cortex, and that there was also an increase in the amygdala of the control rats treated with lamotrigine. The carbonyl protein was increased in the prefrontal cortex of the stressed group treated with saline, however, the lamotrigine treatment reversed this effect. The treatment with lamotrigine increased the superoxide dismutase (SOD) and catalase activity (CAT) activities in the amygdala of stressed rats. The protein kinase B (PKB/Akt) was reduced in the amygdala in the stressed group treated with saline or lamotrigine. We suggest that the antidepressant-like effect of lamotrigine on anhedonic behavior may be related at least in part to its effects on the oxidative stress parameters and AKT.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Abelaira HM,Réus GZ,Ribeiro KF,Steckert AV,Mina F,Rosa DV,Santana CV,Romano-Silva MA,Dal-Pizzol F,Quevedo Jdoi
10.1016/j.neures.2013.02.002subject
Has Abstractpub_date
2013-04-01 00:00:00pages
324-30issue
4eissn
0168-0102issn
1872-8111pii
S0168-0102(13)00035-7journal_volume
75pub_type
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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更新日期：2009-02-01 00:00:00
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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更新日期：2016-12-01 00:00:00
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journal_title：Neuroscience research
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更新日期：2014-01-01 00:00:00
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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更新日期：1996-12-01 00:00:00
