Abstract：
:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In voltage-clamp experiments, a TTX-sensitive Na current was activated at membrane potentials more positive than -50 mV. A low voltage activated (LVA) Ca current and a high voltage activated (HVA) Ca current were observed. The LVA Ca current was activated from -65 mV and showed a voltage dependent inactivation. The HVA Ca current was activated from -40 mV and did not show any inactivation. The LVA Ca current and the HVA Ca current were sensitive to Ni2+ (0.1 mM) and Nifedipine (10-20 mM), respectively. NMC neurons showed a TEA-sensitive K current and a 4-AP-sensitive K current. With 4-AP (0.5 mM) in a bathing medium, the threshold of action potential was decreased to -49 mV and the timing of action potential generation showed a wider distribution than that of control. Ni2+ (0.1 mM) reversed effects of 4-AP on the threshold and the variability of action potential onsets. It is concluded that a 4-AP-sensitive current counteracts the LVA Ca current that facilitates Na spike generation, and sets a threshold to a higher level for generating a single action potential at a precise timing following synaptic inputs from the auditory nerve.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Koyano K,Funabiki K,Ohmori Hdoi
10.1016/0168-0102(96)01071-1subject
Has Abstractpub_date
1996-09-01 00:00:00pages
29-45issue
1eissn
0168-0102issn
1872-8111pii
S0168010296010711journal_volume
26pub_type
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