Abstract：
:Temporal changes in kainate-induced seizure activity and hippocampal NO generation were evaluated simultaneously in conscious rats by using in vivo microdialysis and by determining the concentrations of nitrite and nitrate in perfusates. Intraperitoneal injection of kainic acid produced 'wet dog shake', focal seizure of the limbs and neck, hypersalivation, or generalized convulsion. These behavioral changes peaked at 120 min after the drug challenge and lasted for about 100 min. In contrast, the concentrations of NO metabolites, nitrite and nitrate, in the hippocampal perfusates increased rapidly and reached a plateau level at 40 min after the injection, and the level remained high for over 220 min. The increase was more marked in animals presenting severe seizures than those presenting mild ones. Pre-treatment with 25 mg/kg N(G)-nitro-L-arginine methyl ester promoted the severity of kainate-induced seizures, but it suppressed the increase in NO metabolites. These results suggest that kainic acid enhances hippocampal NO generation in a severity-related manner of the induced seizures. The enhanced NO generation upon kainate challenge appears mainly to be involved in seizure suppression.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kashihara K,Sakai K,Marui K,Shohmori Tdoi
10.1016/s0168-0102(98)00086-8subject
Has Abstractpub_date
1998-11-01 00:00:00pages
189-94issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(98)00086-8journal_volume
32pub_type
杂志文章abstract：:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01071-1
更新日期：1996-09-01 00:00:00
abstract：:The subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.02.001
更新日期：2020-01-01 00:00:00
abstract：:This study was to aim at investigating the potential interaction for the serotonin receptor gene (5-HTR) 2A and serotonin transporter gene (5-HTTLPR) polymorphisms in the development of schizophrenia, as well as the interaction of the two polymorphisms in relation with symptomatology, family history, age of onset and ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.03.006
更新日期：2005-06-01 00:00:00
abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.12.019
更新日期：2021-01-01 00:00:00
abstract：:Over the last few decades, motor imagery has attracted the attention of researchers as a prototypical example of 'embodied cognition' and also as a basis for neuro-rehabilitation and brain-machine interfaces. The current definition of motor imagery is widely accepted, but it is important to note that various abilities...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2015.11.003
更新日期：2016-03-01 00:00:00
abstract：:The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.02.006
更新日期：2015-05-01 00:00:00
abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.09.010
更新日期：2005-01-01 00:00:00
abstract：:Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.04.002
更新日期：2012-07-01 00:00:00
abstract：:Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.10.005
更新日期：2006-01-01 00:00:00
abstract：:Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.02.003
更新日期：2014-04-01 00:00:00
abstract：:Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.003
更新日期：2015-05-01 00:00:00
abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00216-4
更新日期：2001-06-01 00:00:00
abstract：:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00208-0
更新日期：2003-02-01 00:00:00
abstract：:In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01060-7
更新日期：1996-07-01 00:00:00
abstract：:Effects of 1-naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors were studied in cultured rat hippocampal neurons using the whole-cell patch clamp technique. A population of cultured neurons had ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00067-9
更新日期：1997-09-01 00:00:00
abstract：:Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.005
更新日期：2006-12-01 00:00:00
abstract：:We studied hippocampal cellular proliferation and neurogenesis processes in a model of transient global cerebral ischemia in gerbils by labelling dividing cells with 5'-Bromo-2'-deoxyuridine (BrdU). Surrounding the region of selective neuronal death (CA1 pyramidal layer of the hippocampus), an important increase in re...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.01.008
更新日期：2008-05-01 00:00:00
abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.003
更新日期：2006-12-01 00:00:00
abstract：:Although the rat has been the predominant rodent used to investigate the pathophysiology and treatment of experimental spinal cord injury (SCI), the increasing availability of transgenic animals has led to greater use of mouse models. However, behavioral assessment after SCI in mice has been less extensively investiga...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.02.009
更新日期：2010-06-01 00:00:00
abstract：:The influence of the phosphorylation dephosphorylation states on the gamma-aminobutyric acid (GABA) transporter activity of synaptic plasma membranes (SPM) was studied by using either specific phosphatase inhibitors or activators. Calyculin A and okadaic acid (phosphatase 1 and phosphatase 2A inhibitors) inhibited the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00107-2
更新日期：1999-01-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00201-8
更新日期：2003-01-01 00:00:00
abstract：:Education involves learning new information and acquiring cognitive skills. These require various cognitive processes including learning, memory, and language. Since cognitive processes activate associated brain areas, we proposed that the brains of elderly people with longer education periods would show traces of rep...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.009
更新日期：2015-05-01 00:00:00
abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00065-8
更新日期：2003-07-01 00:00:00
abstract：:This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00245-0
更新日期：2001-08-01 00:00:00
abstract：:Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.006
更新日期：2018-08-01 00:00:00
abstract：:Opiates have been used extensively in the treatment of pain but with the severe side effect of addiction, which is believed to be related to opiates' direct (primary) or indirect (secondary) neurotoxicity. In this study, the effects of opioids on cell growth and apoptosis have been examined in human neuroblastoma cell...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00080-1
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.06.009
更新日期：2008-10-01 00:00:00
abstract：:Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00034-5
更新日期：1997-06-01 00:00:00
abstract：:We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.06.003
更新日期：2015-11-01 00:00:00
abstract：:The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.02.006
更新日期：2012-05-01 00:00:00
