Abstract:
:This study was to aim at investigating the potential interaction for the serotonin receptor gene (5-HTR) 2A and serotonin transporter gene (5-HTTLPR) polymorphisms in the development of schizophrenia, as well as the interaction of the two polymorphisms in relation with symptomatology, family history, age of onset and antipsychotic response. Genomic DNA analysis with polymerase chain reaction (PCR) was used for the genotyping. One hundred and eleven (111) patients with schizophrenia and 172 normal controls participated in the study. We did not find any association between the individual polymorphism and schizophrenia. The significant interaction effect between 5-HTTLPR and 5-HTR2A polymorphisms on the development of schizophrenia as well as on the antipsychotics response, family history, symptomatology and age at onset, was not found. However, subject with 5-HTR2A*TT genotype were found to have lower age of onset, compared to their counterparts (p=0.01). These results suggest that the interaction between 5-HTTLPR and 5-HTR2A polymorphisms may not contribute to susceptibility to schizophrenia as well as some clinical factors such as antipsychotic response, at least in the Korean population.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Pae CU,Artioli P,Serretti A,Kim TS,Kim JJ,Lee CU,Lee SJ,Lee C,Paik IHdoi
10.1016/j.neures.2005.03.006subject
Has Abstractpub_date
2005-06-01 00:00:00pages
195-9issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(05)00091-Xjournal_volume
52pub_type
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