Abstract：
:The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation of the right olfactory bulb, rats received rostrocaudal transection injuries on the left LOT at different levels between the olfactory bulb and the middle cerebral artery. Olfactory function of LOT-transected rats was studied by examining their olfactory ability to discriminate between the smell of water and cycloheximide solution, a strong repellent for rodents. Rats were divided into two groups based on their olfactory discriminative abilities. The olfaction positive (+) group achieved 83%± 1% correct responses and the distances of the LOT-transected sites from the middle cerebral artery of this group ranged between 0.8 and 2.4mm (n=8). The olfaction negative (-) group achieved 48%± 1% correct responses and the distances of the LOT-transected sites from the middle cerebral artery ranged between 2.5 and 4.2mm (n=10). From these data, we concluded that the site of the LOT critical for olfactory function is located approximately 2.5mm from the middle cerebral artery.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Sekiguchi Y,Fukushima N,Yokouchi K,Kawagishi K,Hirayama S,Moriizumi Tdoi
10.1016/j.neures.2012.02.006subject
Has Abstractpub_date
2012-05-01 00:00:00pages
17-23issue
1eissn
0168-0102issn
1872-8111pii
S0168-0102(12)00027-2journal_volume
73pub_type
杂志文章abstract：:The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00160-8
更新日期：2002-12-01 00:00:00
abstract：:Aging is a natural biological process associated with several neurological disorders along with the biochemical changes in brain. Aim of the present investigation is to study the effect of carnosine (0.5-2.5μg/kg/day, i.t. for 21 consecutive days) on aging-induced changes in brain regional (cerebral cortex, hippocampu...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.09.009
更新日期：2015-03-01 00:00:00
abstract：:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.02.002
更新日期：2013-04-01 00:00:00
abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.12.003
更新日期：2004-04-01 00:00:00
abstract：:A group of brain acid-soluble proteins (BASPs) is preliminarily characterized. In some respects BASPs are similar to high mobility group (HMG) proteins, but in contrast to HMG, all BASPs are very acidic (pI 4.4-4.6) and show abnormal mobility during SDS-PAGE electrophoresis. BASP2-1 and BASP2-2 are identified as the t...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90146-5
更新日期：1994-03-01 00:00:00
abstract：:Over the last few decades, motor imagery has attracted the attention of researchers as a prototypical example of 'embodied cognition' and also as a basis for neuro-rehabilitation and brain-machine interfaces. The current definition of motor imagery is widely accepted, but it is important to note that various abilities...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2015.11.003
更新日期：2016-03-01 00:00:00
abstract：:GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01102-9
更新日期：1996-10-01 00:00:00
abstract：:The facilitatory masseteric muscle response (FMR) elicited by polyurethane foam strip application between the opposing molars during cortically-induced rhythmic jaw movements (CRJMs) was induced earlier than masticatory force onset. The occurrence of this early response of the FMR (e-FMR) could not be explained by a s...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00192-9
更新日期：2001-01-01 00:00:00
abstract：:We suggest a time-varying partial correlation as a statistical measure of dynamic functional connectivity (dFC) in the human brain. Traditional statistical models often assume specific distributions on the measured data such as the Gaussian distribution, which prohibits their application to neuroimaging data analysis....
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2020.06.006
更新日期：2020-07-03 00:00:00
abstract：:Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.10.006
更新日期：2014-02-01 00:00:00
abstract：:Hippocalcin is a recently identified Ca(2+)-binding protein with three EF-hand structures, dominantly expressed in the hippocampal pyramidal layer. The complete amino acid sequence of hippocalcin deduced from the cDNA is composed of 195 residues, has a calculated molecular mass of 22,574 daltons, and has a striking se...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(93)90112-4
更新日期：1993-09-01 00:00:00
abstract：:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01071-1
更新日期：1996-09-01 00:00:00
abstract：:Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune re...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.01.003
更新日期：2017-06-01 00:00:00
abstract：:Tissue-type plasminogen activator (tPA) is a serine protease that converts the inactive precursor plasminogen to the active protease plasmin. In the central nervous system, tPA has been suggested to participate in plasticity, memory and the neuronal degeneration caused by excitotoxins, but its precise functions during...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00125-4
更新日期：1999-02-01 00:00:00
abstract：:In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01060-7
更新日期：1996-07-01 00:00:00
abstract：:Pedunculopontine nucleus areas were lesioned bilaterally in the rat by local injection of kainic acid. When rats so treated were tested for active avoidance behavior in shuttle boxes we found that their avoidance acquisition was completely abolished, whereas their intertrial locomotor activity and escape behavior were...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90024-2
更新日期：1989-04-01 00:00:00
abstract：:Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.010
更新日期：2015-05-01 00:00:00
abstract：:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.10.007
更新日期：2012-02-01 00:00:00
abstract：:Area TE sends dense projections to the perirhinal cortex in macaque monkeys, an area in which we previously observed flexible signals regarding upcoming reward outcomes during a conditional-association cued-reward task. To investigate neuronal processing during the generation of information on upcoming reward outcomes...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:Sensitivities of neurons to acetylcholine (ACh), noradrenaline (NA) and dopamine (DA) were investigated at different depths of the dorsolateral prefrontal cortex (PFC) in awake or halothane-anesthetized macaque monkeys, using microiontophoretic techniques with multi-barreled electrodes. The laminar locations of tested...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(85)90004-5
更新日期：1985-04-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.06.021
更新日期：2005-11-01 00:00:00
abstract：:Catecholamine neurotransmitters--dopamine, noradrenaline (norepinephrine), adrenaline (epinephrine)--are synthesized in catecholaminergic neurons from tyrosine, via dopa, dopamine and noradrenaline, to adrenaline. Four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydr...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90001-f
更新日期：1991-10-01 00:00:00
abstract：:Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(85)90021-5
更新日期：1985-08-01 00:00:00
abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.07.003
更新日期：2020-06-01 00:00:00
abstract：:To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.015
更新日期：2009-08-01 00:00:00
abstract：:We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(84)90036-1
更新日期：1984-10-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopamine (DA) system. Although previous studies have shown that pretreatment with GDNF could prevent degenerative changes of nigrostriatal DA system ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00097-3
更新日期：2000-04-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00201-8
更新日期：2003-01-01 00:00:00
abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)00864-c
更新日期：1995-02-01 00:00:00
abstract：:The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.08.008
更新日期：2011-12-01 00:00:00
