Abstract：
:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is recovered in a low-density fraction after the treatment of the membrane with a non-ionic detergent such as Triton X-100. The enrichment of cholesterol and sphingolipids is ascribed to be responsible for the detergent insolubility. In this study we focused on the cyclic nucleotide signaling process in rafts prepared from the cerebral cortex of 10-day-old rat and the synaptic plasma membrane fraction and found the presence of a high cAMP and cGMP phosphodiesterase (PDE) activity. The activity was effectively inhibited with erythro-9-(2-hydroxy-3-nonyl)adenine, a PDE2-specific inhibitor but not with other inhibitors such as vinpocetine, quazione, or zaprinast. Further western blotting analysis confirmed the localization of PDE2 in the raft fraction. The presence of adenylyl cyclase V/VI and PKA in the raft fraction was also shown with Western blotting. These results suggest the participation of the raft in the cyclic nucleotide signaling cascade in neurons.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Noyama K,Maekawa Sdoi
10.1016/s0168-0102(02)00208-0subject
Has Abstractpub_date
2003-02-01 00:00:00pages
141-8issue
2eissn
0168-0102issn
1872-8111pii
S0168010202002080journal_volume
45pub_type
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更新日期：2008-03-01 00:00:00
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更新日期：2013-09-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：Neuroscience research
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